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Age-related difference in immune responses to respiratory syncytial virus infection in young children.
Pediatr Allergy Immunol. 2007 Mar; 18(2):94-9.PA

Abstract

There have been longitudinal studies of the developmental change of the immune system during the first year of life. The aim of this study was to investigate if there is any age-related difference in cytokine responses to respiratory syncytial virus (RSV) infection between the patients under 6 months of age and the patients over 12 months of age compared with age-matched controls. Forty-five children < or =24 months of age who were admitted with acute RSV bronchiolitis were enrolled. The patients were divided into two groups: the infants < or =6 months old and the young children > or =12 months old. Immune response to RSV infection was determined by measuring the serum concentrations of cytokines and compared with age-matched controls. Serum samples were obtained on admission and analyzed for interferon (IFN)-gamma, interleukins (IL)-10, -13, and -4 using ELISA. Comparing the cytokine levels of two control groups, both IFN-gamma and IL-13 were lower in the children > or =12 months of age than in the infants < or =6 months of age. IL-10 and IL-4 showed no significant changes with age. Comparing with age-matched controls, IFN-gamma levels were significantly higher in RSV group > or =12 months of age, but showed a tendency toward lower levels in RSV group < or =6 months of age. Both IL-10 and IL-13 levels were significantly higher in RSV group > or =12 months of age, but showed no significant difference in RSV group < or =6 months of age. Our study demonstrated a significant age-related difference in immune response to RSV infection during early life. It suggests that the developmental changes in cytokine responses to RSV infection may be considered in the control of RSV bronchiolitis in young children.

Authors+Show Affiliations

Department of Pediatrics, School of Medicine, Catholic University of Taegu, Taegu, Korea. hlchung@cu.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17338780

Citation

Chung, Hai Lee, et al. "Age-related Difference in Immune Responses to Respiratory Syncytial Virus Infection in Young Children." Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, vol. 18, no. 2, 2007, pp. 94-9.
Chung HL, Park HJ, Kim SY, et al. Age-related difference in immune responses to respiratory syncytial virus infection in young children. Pediatr Allergy Immunol. 2007;18(2):94-9.
Chung, H. L., Park, H. J., Kim, S. Y., & Kim, S. G. (2007). Age-related difference in immune responses to respiratory syncytial virus infection in young children. Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology, 18(2), 94-9.
Chung HL, et al. Age-related Difference in Immune Responses to Respiratory Syncytial Virus Infection in Young Children. Pediatr Allergy Immunol. 2007;18(2):94-9. PubMed PMID: 17338780.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related difference in immune responses to respiratory syncytial virus infection in young children. AU - Chung,Hai Lee, AU - Park,Hye Jin, AU - Kim,So Yeon, AU - Kim,Sang Gyung, PY - 2007/3/7/pubmed PY - 2007/5/2/medline PY - 2007/3/7/entrez SP - 94 EP - 9 JF - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JO - Pediatr Allergy Immunol VL - 18 IS - 2 N2 - There have been longitudinal studies of the developmental change of the immune system during the first year of life. The aim of this study was to investigate if there is any age-related difference in cytokine responses to respiratory syncytial virus (RSV) infection between the patients under 6 months of age and the patients over 12 months of age compared with age-matched controls. Forty-five children < or =24 months of age who were admitted with acute RSV bronchiolitis were enrolled. The patients were divided into two groups: the infants < or =6 months old and the young children > or =12 months old. Immune response to RSV infection was determined by measuring the serum concentrations of cytokines and compared with age-matched controls. Serum samples were obtained on admission and analyzed for interferon (IFN)-gamma, interleukins (IL)-10, -13, and -4 using ELISA. Comparing the cytokine levels of two control groups, both IFN-gamma and IL-13 were lower in the children > or =12 months of age than in the infants < or =6 months of age. IL-10 and IL-4 showed no significant changes with age. Comparing with age-matched controls, IFN-gamma levels were significantly higher in RSV group > or =12 months of age, but showed a tendency toward lower levels in RSV group < or =6 months of age. Both IL-10 and IL-13 levels were significantly higher in RSV group > or =12 months of age, but showed no significant difference in RSV group < or =6 months of age. Our study demonstrated a significant age-related difference in immune response to RSV infection during early life. It suggests that the developmental changes in cytokine responses to RSV infection may be considered in the control of RSV bronchiolitis in young children. SN - 0905-6157 UR - https://www.unboundmedicine.com/medline/citation/17338780/Age_related_difference_in_immune_responses_to_respiratory_syncytial_virus_infection_in_young_children_ L2 - https://doi.org/10.1111/j.1399-3038.2006.00501.x DB - PRIME DP - Unbound Medicine ER -