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Subacute cutaneous lupus erythematosus with bullae associated with porphyria cutanea tarda.
J Dtsch Dermatol Ges 2007; 5(3):220-2JD

Abstract

A 58-year-old patient presented with both annular and polycyclic as well as vesicular lesions. Histology revealed an interface dermatitis with focal hyperkeratosis and subepidermal blistering. Antinuclear antibodies were elevated (1 : 1280) and autoantibodies against Ro-SS-A were found. Based on these findings we made a diagnosis of subacute cutaneous lupus erythematosus (SCLE) with blister formation. Additionally, we diagnosed porphyria cutanea tarda (PCT) triggered by alcohol abuse. Treatment with systemic corticosteroids and low-dose hydroxy-chloroquine led to rapid resolution of the skin changes. SCLE with blister formation is a rare cause of bullous skin eruptions and has to be distinguished from bullous autoimmune diseases as well as from bullous SLE. Recognition of concomitant PCT, which may be associated with all forms of LE, is especially important because of the therapeutic implications, since a reduced dosage of antimalarials is required.

Authors+Show Affiliations

Department of Dermatology, Mannheim University Clinic, Heidelberg University, Mannheim, Germany. wiebke.peitsch@haut.ma.uni-heidelberg.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng ger

PubMed ID

17338797

Citation

Peitsch, Wiebke K., et al. "Subacute Cutaneous Lupus Erythematosus With Bullae Associated With Porphyria Cutanea Tarda." Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, vol. 5, no. 3, 2007, pp. 220-2.
Peitsch WK, Lorentz K, Goebeler M, et al. Subacute cutaneous lupus erythematosus with bullae associated with porphyria cutanea tarda. J Dtsch Dermatol Ges. 2007;5(3):220-2.
Peitsch, W. K., Lorentz, K., Goebeler, M., & Goerdt, S. (2007). Subacute cutaneous lupus erythematosus with bullae associated with porphyria cutanea tarda. Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 5(3), pp. 220-2.
Peitsch WK, et al. Subacute Cutaneous Lupus Erythematosus With Bullae Associated With Porphyria Cutanea Tarda. J Dtsch Dermatol Ges. 2007;5(3):220-2. PubMed PMID: 17338797.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subacute cutaneous lupus erythematosus with bullae associated with porphyria cutanea tarda. AU - Peitsch,Wiebke K, AU - Lorentz,Katharina, AU - Goebeler,Matthias, AU - Goerdt,Sergij, PY - 2007/3/7/pubmed PY - 2007/3/27/medline PY - 2007/3/7/entrez SP - 220 EP - 2 JF - Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG JO - J Dtsch Dermatol Ges VL - 5 IS - 3 N2 - A 58-year-old patient presented with both annular and polycyclic as well as vesicular lesions. Histology revealed an interface dermatitis with focal hyperkeratosis and subepidermal blistering. Antinuclear antibodies were elevated (1 : 1280) and autoantibodies against Ro-SS-A were found. Based on these findings we made a diagnosis of subacute cutaneous lupus erythematosus (SCLE) with blister formation. Additionally, we diagnosed porphyria cutanea tarda (PCT) triggered by alcohol abuse. Treatment with systemic corticosteroids and low-dose hydroxy-chloroquine led to rapid resolution of the skin changes. SCLE with blister formation is a rare cause of bullous skin eruptions and has to be distinguished from bullous autoimmune diseases as well as from bullous SLE. Recognition of concomitant PCT, which may be associated with all forms of LE, is especially important because of the therapeutic implications, since a reduced dosage of antimalarials is required. SN - 1610-0387 UR - https://www.unboundmedicine.com/medline/citation/17338797/Subacute_cutaneous_lupus_erythematosus_with_bullae_associated_with_porphyria_cutanea_tarda_ L2 - https://doi.org/10.1111/j.1610-0387.2007.06201.x DB - PRIME DP - Unbound Medicine ER -