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Subacute cutaneous lupus erythematosus with bullae associated with porphyria cutanea tarda.

Abstract

A 58-year-old patient presented with both annular and polycyclic as well as vesicular lesions. Histology revealed an interface dermatitis with focal hyperkeratosis and subepidermal blistering. Antinuclear antibodies were elevated (1 : 1280) and autoantibodies against Ro-SS-A were found. Based on these findings we made a diagnosis of subacute cutaneous lupus erythematosus (SCLE) with blister formation. Additionally, we diagnosed porphyria cutanea tarda (PCT) triggered by alcohol abuse. Treatment with systemic corticosteroids and low-dose hydroxy-chloroquine led to rapid resolution of the skin changes. SCLE with blister formation is a rare cause of bullous skin eruptions and has to be distinguished from bullous autoimmune diseases as well as from bullous SLE. Recognition of concomitant PCT, which may be associated with all forms of LE, is especially important because of the therapeutic implications, since a reduced dosage of antimalarials is required.

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  • Authors+Show Affiliations

    ,

    Department of Dermatology, Mannheim University Clinic, Heidelberg University, Mannheim, Germany. wiebke.peitsch@haut.ma.uni-heidelberg.de

    , ,

    Source

    MeSH

    Alcoholism
    Anti-Infective Agents, Local
    Anti-Inflammatory Agents
    Blister
    Drug Combinations
    Humans
    Lupus Erythematosus, Cutaneous
    Male
    Middle Aged
    Porphyria Cutanea Tarda
    Steroids
    Treatment Outcome

    Pub Type(s)

    Case Reports
    Journal Article

    Language

    eng ger

    PubMed ID

    17338797

    Citation

    Peitsch, Wiebke K., et al. "Subacute Cutaneous Lupus Erythematosus With Bullae Associated With Porphyria Cutanea Tarda." Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, vol. 5, no. 3, 2007, pp. 220-2.
    Peitsch WK, Lorentz K, Goebeler M, et al. Subacute cutaneous lupus erythematosus with bullae associated with porphyria cutanea tarda. J Dtsch Dermatol Ges. 2007;5(3):220-2.
    Peitsch, W. K., Lorentz, K., Goebeler, M., & Goerdt, S. (2007). Subacute cutaneous lupus erythematosus with bullae associated with porphyria cutanea tarda. Journal Der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG, 5(3), pp. 220-2.
    Peitsch WK, et al. Subacute Cutaneous Lupus Erythematosus With Bullae Associated With Porphyria Cutanea Tarda. J Dtsch Dermatol Ges. 2007;5(3):220-2. PubMed PMID: 17338797.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Subacute cutaneous lupus erythematosus with bullae associated with porphyria cutanea tarda. AU - Peitsch,Wiebke K, AU - Lorentz,Katharina, AU - Goebeler,Matthias, AU - Goerdt,Sergij, PY - 2007/3/7/pubmed PY - 2007/3/27/medline PY - 2007/3/7/entrez SP - 220 EP - 2 JF - Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG JO - J Dtsch Dermatol Ges VL - 5 IS - 3 N2 - A 58-year-old patient presented with both annular and polycyclic as well as vesicular lesions. Histology revealed an interface dermatitis with focal hyperkeratosis and subepidermal blistering. Antinuclear antibodies were elevated (1 : 1280) and autoantibodies against Ro-SS-A were found. Based on these findings we made a diagnosis of subacute cutaneous lupus erythematosus (SCLE) with blister formation. Additionally, we diagnosed porphyria cutanea tarda (PCT) triggered by alcohol abuse. Treatment with systemic corticosteroids and low-dose hydroxy-chloroquine led to rapid resolution of the skin changes. SCLE with blister formation is a rare cause of bullous skin eruptions and has to be distinguished from bullous autoimmune diseases as well as from bullous SLE. Recognition of concomitant PCT, which may be associated with all forms of LE, is especially important because of the therapeutic implications, since a reduced dosage of antimalarials is required. SN - 1610-0387 UR - https://www.unboundmedicine.com/medline/citation/17338797/Subacute_cutaneous_lupus_erythematosus_with_bullae_associated_with_porphyria_cutanea_tarda_ L2 - https://doi.org/10.1111/j.1610-0387.2007.06201.x DB - PRIME DP - Unbound Medicine ER -