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Sensitization in early age to food allergens in children with atopic dermatitis.
Allergol Immunopathol (Madr) 2007 Jan-Feb; 35(1):15-20AI

Abstract

BACKGROUND

Clinical and laboratory evidence increasingly supports the notion that food allergy plays a role in the pathogenesis of atopic dermatitis (AD). However, the prevalence of clinically significant food hypersensitivity among children with AD remains an unanswered question.

OBJECTIVE

To prospectively determine the prevalence of IgE-mediated food hypersensitivity among patients referred to a dermatology department for evaluation of AD, and to analyze the clinical relevance of these sensitizations in AD.

METHODS

We studied 44 infants of both sexes, aged less than 12 months old, who attended the dermatology department with symptoms of AD. Compliance with Hanifin-Rajka criteria was confirmed and the severity of AD was evaluated using the SCORAD index. IgE-mediated sensitization to cow's milk, alpha-lactalbumin, beta-lactoglobulin, casein, egg-white, egg-albumin, ovomucoid and foods introduced into the diet was studied using the skin prick test (SPT) and measurement of specific serum IgE (sIgE) by CAP System fluorescein-enzyme immunoassay. Cow's milk, as well as suspected foods from the clinical history or those with a positive SPT and/or sIgE, were withdrawn from the diet to evaluate improvement in AD, and an open controlled challenge test was carried out.

RESULTS

Of the 44 patients studied, sensitization to foods was detected in 27 (61 %). No changes were observed in AD during the elimination diet or when the eliminated foods were subsequently reintroduced into the diet. The results of open controlled food challenges were positive in 12 patients (27 %).

CONCLUSIONS

A high prevalence of food sensitization was found in infants with AD. The most frequent sensitization observed was to egg, although with little clinical relevance since this food had not been introduced into the diet. In the sample studied, the clinical relevance of the observed food hypersensitivities was confirmed in relation to AD. Further studies are required to confirm these results.

Authors+Show Affiliations

Unit of Allergology, Consorci Hospital General Universitari, Faculty of Medicine, University of Valencia.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17338897

Citation

García, C, et al. "Sensitization in Early Age to Food Allergens in Children With Atopic Dermatitis." Allergologia Et Immunopathologia, vol. 35, no. 1, 2007, pp. 15-20.
García C, El-Qutob D, Martorell A, et al. Sensitization in early age to food allergens in children with atopic dermatitis. Allergol Immunopathol (Madr). 2007;35(1):15-20.
García, C., El-Qutob, D., Martorell, A., Febrer, I., Rodríguez, M., Cerdá, J. C., & Félix, R. (2007). Sensitization in early age to food allergens in children with atopic dermatitis. Allergologia Et Immunopathologia, 35(1), pp. 15-20.
García C, et al. Sensitization in Early Age to Food Allergens in Children With Atopic Dermatitis. Allergol Immunopathol (Madr). 2007;35(1):15-20. PubMed PMID: 17338897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sensitization in early age to food allergens in children with atopic dermatitis. AU - García,C, AU - El-Qutob,D, AU - Martorell,A, AU - Febrer,I, AU - Rodríguez,M, AU - Cerdá,J C, AU - Félix,R, PY - 2007/3/7/pubmed PY - 2007/5/26/medline PY - 2007/3/7/entrez SP - 15 EP - 20 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 35 IS - 1 N2 - BACKGROUND: Clinical and laboratory evidence increasingly supports the notion that food allergy plays a role in the pathogenesis of atopic dermatitis (AD). However, the prevalence of clinically significant food hypersensitivity among children with AD remains an unanswered question. OBJECTIVE: To prospectively determine the prevalence of IgE-mediated food hypersensitivity among patients referred to a dermatology department for evaluation of AD, and to analyze the clinical relevance of these sensitizations in AD. METHODS: We studied 44 infants of both sexes, aged less than 12 months old, who attended the dermatology department with symptoms of AD. Compliance with Hanifin-Rajka criteria was confirmed and the severity of AD was evaluated using the SCORAD index. IgE-mediated sensitization to cow's milk, alpha-lactalbumin, beta-lactoglobulin, casein, egg-white, egg-albumin, ovomucoid and foods introduced into the diet was studied using the skin prick test (SPT) and measurement of specific serum IgE (sIgE) by CAP System fluorescein-enzyme immunoassay. Cow's milk, as well as suspected foods from the clinical history or those with a positive SPT and/or sIgE, were withdrawn from the diet to evaluate improvement in AD, and an open controlled challenge test was carried out. RESULTS: Of the 44 patients studied, sensitization to foods was detected in 27 (61 %). No changes were observed in AD during the elimination diet or when the eliminated foods were subsequently reintroduced into the diet. The results of open controlled food challenges were positive in 12 patients (27 %). CONCLUSIONS: A high prevalence of food sensitization was found in infants with AD. The most frequent sensitization observed was to egg, although with little clinical relevance since this food had not been introduced into the diet. In the sample studied, the clinical relevance of the observed food hypersensitivities was confirmed in relation to AD. Further studies are required to confirm these results. SN - 0301-0546 UR - https://www.unboundmedicine.com/medline/citation/17338897/Sensitization_in_early_age_to_food_allergens_in_children_with_atopic_dermatitis_ L2 - http://www.elsevier.es/en/linksolver/ft/ivp/0301-0546/35/15 DB - PRIME DP - Unbound Medicine ER -