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Risk factors for acute myocardial infarction in Latin America: the INTERHEART Latin American study.
Circulation. 2007 Mar 06; 115(9):1067-74.Circ

Abstract

BACKGROUND

Current knowledge of the impact of cardiovascular risk factors in Latin America is limited.

METHODS AND RESULTS

As part of the INTERHEART study, 1237 cases of first acute myocardial infarction and 1888 age-, sex-, and center-matched controls were enrolled from Argentina, Brazil, Colombia, Chile, Guatemala, and Mexico. History of smoking, hypertension, diabetes mellitus, diet, physical activity, alcohol consumption, psychosocial factors, anthropometry, and blood pressure were recorded. Nonfasting blood samples were analyzed for apolipoproteins A-1 and B-100. Logistic regression was used to estimate multivariate adjusted odds ratios (ORs) and their 95% confidence intervals (CIs). Persistent psychosocial stress (OR, 2.81; 95% CI, 2.07 to 3.82), history of hypertension (OR, 2.81; 95% CI, 2.39 to 3.31), diabetes mellitus (OR, 2.59; 95% CI, 2.09 to 3.22), current smoking (OR, 2.31; 95% CI, 1.97 to 2.71), increased waist-to-hip ratio (OR for first versus third tertile, 2.49; 95% CI, 1.97 to 3.14), and increased ratio of apolipoprotein B to A-1 (OR for first versus third tertile, 2.31; 95% CI, 1.83 to 2.94) were associated with higher risk of acute myocardial infarction. Daily consumption of fruits or vegetables (OR, 0.63; 95% CI, 0.51 to 0.78) and regular exercise (OR, 0.67; 95% CI, 0.55 to 0.82) reduced the risk of acute myocardial infarction. Abdominal obesity, abnormal lipids, and smoking were associated with high population-attributable risks of 48.5%, 40.8%, and 38.4%, respectively. Collectively, these risk factors accounted for 88% of the population-attributable risk.

CONCLUSIONS

Interventions aimed at decreasing behavioral risk factors, lowering blood pressure, and modifying lipids could have a large impact on the risk of acute myocardial infarction among Latin Americans.

Authors+Show Affiliations

Facultad de Medicina, Universidad de La Frontera M, Montt 112 Temuco, Chile. flanas@ufro.clNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17339564

Citation

Lanas, Fernando, et al. "Risk Factors for Acute Myocardial Infarction in Latin America: the INTERHEART Latin American Study." Circulation, vol. 115, no. 9, 2007, pp. 1067-74.
Lanas F, Avezum A, Bautista LE, et al. Risk factors for acute myocardial infarction in Latin America: the INTERHEART Latin American study. Circulation. 2007;115(9):1067-74.
Lanas, F., Avezum, A., Bautista, L. E., Diaz, R., Luna, M., Islam, S., & Yusuf, S. (2007). Risk factors for acute myocardial infarction in Latin America: the INTERHEART Latin American study. Circulation, 115(9), 1067-74.
Lanas F, et al. Risk Factors for Acute Myocardial Infarction in Latin America: the INTERHEART Latin American Study. Circulation. 2007 Mar 6;115(9):1067-74. PubMed PMID: 17339564.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for acute myocardial infarction in Latin America: the INTERHEART Latin American study. AU - Lanas,Fernando, AU - Avezum,Alvaro, AU - Bautista,Leonelo E, AU - Diaz,Rafael, AU - Luna,Max, AU - Islam,Shofiqul, AU - Yusuf,Salim, AU - ,, PY - 2007/3/7/pubmed PY - 2007/3/28/medline PY - 2007/3/7/entrez SP - 1067 EP - 74 JF - Circulation JO - Circulation VL - 115 IS - 9 N2 - BACKGROUND: Current knowledge of the impact of cardiovascular risk factors in Latin America is limited. METHODS AND RESULTS: As part of the INTERHEART study, 1237 cases of first acute myocardial infarction and 1888 age-, sex-, and center-matched controls were enrolled from Argentina, Brazil, Colombia, Chile, Guatemala, and Mexico. History of smoking, hypertension, diabetes mellitus, diet, physical activity, alcohol consumption, psychosocial factors, anthropometry, and blood pressure were recorded. Nonfasting blood samples were analyzed for apolipoproteins A-1 and B-100. Logistic regression was used to estimate multivariate adjusted odds ratios (ORs) and their 95% confidence intervals (CIs). Persistent psychosocial stress (OR, 2.81; 95% CI, 2.07 to 3.82), history of hypertension (OR, 2.81; 95% CI, 2.39 to 3.31), diabetes mellitus (OR, 2.59; 95% CI, 2.09 to 3.22), current smoking (OR, 2.31; 95% CI, 1.97 to 2.71), increased waist-to-hip ratio (OR for first versus third tertile, 2.49; 95% CI, 1.97 to 3.14), and increased ratio of apolipoprotein B to A-1 (OR for first versus third tertile, 2.31; 95% CI, 1.83 to 2.94) were associated with higher risk of acute myocardial infarction. Daily consumption of fruits or vegetables (OR, 0.63; 95% CI, 0.51 to 0.78) and regular exercise (OR, 0.67; 95% CI, 0.55 to 0.82) reduced the risk of acute myocardial infarction. Abdominal obesity, abnormal lipids, and smoking were associated with high population-attributable risks of 48.5%, 40.8%, and 38.4%, respectively. Collectively, these risk factors accounted for 88% of the population-attributable risk. CONCLUSIONS: Interventions aimed at decreasing behavioral risk factors, lowering blood pressure, and modifying lipids could have a large impact on the risk of acute myocardial infarction among Latin Americans. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/17339564/Risk_factors_for_acute_myocardial_infarction_in_Latin_America:_the_INTERHEART_Latin_American_study_ L2 - http://www.ahajournals.org/doi/full/10.1161/CIRCULATIONAHA.106.633552?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -