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Influence of body mass index on prostate-specific antigen failure after androgen suppression and radiation therapy for localized prostate cancer.
Cancer. 2007 Apr 15; 109(8):1493-8.C

Abstract

BACKGROUND

Increasing body mass index (BMI) is associated with shorter time to prostate-specific antigen (PSA) failure after radical prostatectomy. Whether BMI is associated with time to PSA failure was investigated in men treated with androgen suppression therapy (AST) and radiation therapy (RT) for clinically localized prostate cancer.

METHODS

The observational prospective cohort study consisted of 102 men with clinically localized prostate cancer who received 70 Gy RT with 6 months of AST on a single arm of a randomized trial between December 1995 and April 2001. Height and weight data were available at baseline for 99 (97%) of the men, from which BMI was calculated. Adjusting for age (continuous) and known prognostic factors including PSA level (continuous), Gleason score, and T-category, Cox regression analyses were performed to analyze whether BMI (continuous) was associated with time to PSA failure (PSA >1.0 ng/mL and increasing >0.2 ng/mL on 2 consecutive visits).

RESULTS

Median age and median BMI (interquartile range [IQR]) at baseline was 72 (69.1-74.7) years and 27.4 (24.8-30.7) kg/m,(2) respectively. In addition to an increasing PSA level (P = .006) and Gleason 8-10 cancer (P = .024), after a median follow-up (IQR) of 6.9 (5.6-8.5) years, an increasing BMI was also significantly associated with a shorter time to PSA failure (adjusted hazard ratio [HR]: 1.10; 95% confidence interval [CI]: 1.01-1.19; P = .026) after RT and AST.

CONCLUSIONS

After adjusting for known prognostic factors, baseline BMI is significantly associated with time to PSA failure after RT and AST for men with clinically localized prostate cancer. Further study is warranted to assess the impact of an increasing BMI after AST administration on PSA failure, prostate cancer-specific, and all-cause mortality.

Authors+Show Affiliations

Department of Radiation Oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA. jefstathiou@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17340594

Citation

Efstathiou, Jason A., et al. "Influence of Body Mass Index On Prostate-specific Antigen Failure After Androgen Suppression and Radiation Therapy for Localized Prostate Cancer." Cancer, vol. 109, no. 8, 2007, pp. 1493-8.
Efstathiou JA, Chen MH, Renshaw AA, et al. Influence of body mass index on prostate-specific antigen failure after androgen suppression and radiation therapy for localized prostate cancer. Cancer. 2007;109(8):1493-8.
Efstathiou, J. A., Chen, M. H., Renshaw, A. A., Loffredo, M. J., & D'Amico, A. V. (2007). Influence of body mass index on prostate-specific antigen failure after androgen suppression and radiation therapy for localized prostate cancer. Cancer, 109(8), 1493-8.
Efstathiou JA, et al. Influence of Body Mass Index On Prostate-specific Antigen Failure After Androgen Suppression and Radiation Therapy for Localized Prostate Cancer. Cancer. 2007 Apr 15;109(8):1493-8. PubMed PMID: 17340594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of body mass index on prostate-specific antigen failure after androgen suppression and radiation therapy for localized prostate cancer. AU - Efstathiou,Jason A, AU - Chen,Ming-Hui, AU - Renshaw,Andrew A, AU - Loffredo,Marian J, AU - D'Amico,Anthony V, PY - 2007/3/7/pubmed PY - 2007/6/15/medline PY - 2007/3/7/entrez SP - 1493 EP - 8 JF - Cancer JO - Cancer VL - 109 IS - 8 N2 - BACKGROUND: Increasing body mass index (BMI) is associated with shorter time to prostate-specific antigen (PSA) failure after radical prostatectomy. Whether BMI is associated with time to PSA failure was investigated in men treated with androgen suppression therapy (AST) and radiation therapy (RT) for clinically localized prostate cancer. METHODS: The observational prospective cohort study consisted of 102 men with clinically localized prostate cancer who received 70 Gy RT with 6 months of AST on a single arm of a randomized trial between December 1995 and April 2001. Height and weight data were available at baseline for 99 (97%) of the men, from which BMI was calculated. Adjusting for age (continuous) and known prognostic factors including PSA level (continuous), Gleason score, and T-category, Cox regression analyses were performed to analyze whether BMI (continuous) was associated with time to PSA failure (PSA >1.0 ng/mL and increasing >0.2 ng/mL on 2 consecutive visits). RESULTS: Median age and median BMI (interquartile range [IQR]) at baseline was 72 (69.1-74.7) years and 27.4 (24.8-30.7) kg/m,(2) respectively. In addition to an increasing PSA level (P = .006) and Gleason 8-10 cancer (P = .024), after a median follow-up (IQR) of 6.9 (5.6-8.5) years, an increasing BMI was also significantly associated with a shorter time to PSA failure (adjusted hazard ratio [HR]: 1.10; 95% confidence interval [CI]: 1.01-1.19; P = .026) after RT and AST. CONCLUSIONS: After adjusting for known prognostic factors, baseline BMI is significantly associated with time to PSA failure after RT and AST for men with clinically localized prostate cancer. Further study is warranted to assess the impact of an increasing BMI after AST administration on PSA failure, prostate cancer-specific, and all-cause mortality. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/17340594/Influence_of_body_mass_index_on_prostate_specific_antigen_failure_after_androgen_suppression_and_radiation_therapy_for_localized_prostate_cancer_ L2 - https://doi.org/10.1002/cncr.22564 DB - PRIME DP - Unbound Medicine ER -