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Prevalence and outcome of juvenile idiopathic arthritis-associated uveitis and relation to articular disease.
J Rheumatol. 2007 May; 34(5):1139-45.JR

Abstract

OBJECTIVE

To determine prevalence and complications of juvenile idiopathic arthritis (JIA)-associated uveitis, and to evaluate risk factors for uveitis and its relation to articular disease.

METHODS

Records of 309 patients with JIA (244 female, 65 male, mean age at onset 4.9 yrs) were retrospectively reviewed. Occurrence of uveitis and complications were assessed among oligoarticular-onset JIA (193 patients), polyarticular-onset JIA (66 patients), and systemic-onset JIA (50 patients). The presence of antinuclear antibodies (ANA) was determined in patients with oligoarticular-onset JIA. Therapy and relapses of uveitis and arthritis were recorded at each visit during the followup (mean followup 7.6 yrs).

RESULTS

Sixty-two patients developed uveitis (20.1%); 57 patients had oligoarticular-, 3 polyarticular-, and 2 systemic-onset JIA. Uveitis was asymptomatic in 56/62 cases. Fifty-five of the 62 patients (88.7%) developed uveitis within 4 years from disease onset. In patients with oligoarticular-onset JIA, an early age at disease onset and the presence of ANA (p < 0.05) and DRB1*11 (p < 0.03) were the best predictors of uveitis, while a polyarticular course was not associated to uveitis (p > 0.05). Active arthritis was present at the first episode of uveitis in 46/62 patients. Forty-four of the 62 patients experienced relapses of uveitis: in 20/62, relapses were concomitant to arthritis relapses; in 24/62 relapses presented without active arthritis. Complications of uveitis developed in 35.5% of the patients (22/62), leading to visual impairment in 13 patients.

CONCLUSION

Current guidelines provide early identification of uveitis in 90% of patients. With the exception of the first episode of uveitis, uveitis and arthritis seem to run different courses; close ophthalmologic scrutiny then should also be maintained during arthritis remission.

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Authors+Show Affiliations

Grassi A
Pediatric Rheumatology Centre, Clinica Pediatrica De Marchi, Milan, Italy. angela.grassi@libero.it
Corona F
No affiliation info available
Casellato A
No affiliation info available
Carnelli V
No affiliation info available
Bardare M
No affiliation info available

MeSH

Antibodies, AntinuclearArthritis, JuvenileBiomarkersChildChild, PreschoolComorbidityFemaleHLA-DR AntigensHLA-DRB1 ChainsHumansInfantItalyMalePrevalenceRecurrenceRetrospective StudiesUveitisVision, Low

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17343317

Citation

Grassi, Angela, et al. "Prevalence and Outcome of Juvenile Idiopathic Arthritis-associated Uveitis and Relation to Articular Disease." The Journal of Rheumatology, vol. 34, no. 5, 2007, pp. 1139-45.
Grassi A, Corona F, Casellato A, et al. Prevalence and outcome of juvenile idiopathic arthritis-associated uveitis and relation to articular disease. J Rheumatol. 2007;34(5):1139-45.
Grassi, A., Corona, F., Casellato, A., Carnelli, V., & Bardare, M. (2007). Prevalence and outcome of juvenile idiopathic arthritis-associated uveitis and relation to articular disease. The Journal of Rheumatology, 34(5), 1139-45.
Grassi A, et al. Prevalence and Outcome of Juvenile Idiopathic Arthritis-associated Uveitis and Relation to Articular Disease. J Rheumatol. 2007;34(5):1139-45. PubMed PMID: 17343317.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and outcome of juvenile idiopathic arthritis-associated uveitis and relation to articular disease. AU - Grassi,Angela, AU - Corona,Fabrizia, AU - Casellato,Aldo, AU - Carnelli,Vittorio, AU - Bardare,Maria, Y1 - 2007/03/01/ PY - 2007/3/9/pubmed PY - 2007/6/23/medline PY - 2007/3/9/entrez SP - 1139 EP - 45 JF - The Journal of rheumatology JO - J Rheumatol VL - 34 IS - 5 N2 - OBJECTIVE: To determine prevalence and complications of juvenile idiopathic arthritis (JIA)-associated uveitis, and to evaluate risk factors for uveitis and its relation to articular disease. METHODS: Records of 309 patients with JIA (244 female, 65 male, mean age at onset 4.9 yrs) were retrospectively reviewed. Occurrence of uveitis and complications were assessed among oligoarticular-onset JIA (193 patients), polyarticular-onset JIA (66 patients), and systemic-onset JIA (50 patients). The presence of antinuclear antibodies (ANA) was determined in patients with oligoarticular-onset JIA. Therapy and relapses of uveitis and arthritis were recorded at each visit during the followup (mean followup 7.6 yrs). RESULTS: Sixty-two patients developed uveitis (20.1%); 57 patients had oligoarticular-, 3 polyarticular-, and 2 systemic-onset JIA. Uveitis was asymptomatic in 56/62 cases. Fifty-five of the 62 patients (88.7%) developed uveitis within 4 years from disease onset. In patients with oligoarticular-onset JIA, an early age at disease onset and the presence of ANA (p < 0.05) and DRB1*11 (p < 0.03) were the best predictors of uveitis, while a polyarticular course was not associated to uveitis (p > 0.05). Active arthritis was present at the first episode of uveitis in 46/62 patients. Forty-four of the 62 patients experienced relapses of uveitis: in 20/62, relapses were concomitant to arthritis relapses; in 24/62 relapses presented without active arthritis. Complications of uveitis developed in 35.5% of the patients (22/62), leading to visual impairment in 13 patients. CONCLUSION: Current guidelines provide early identification of uveitis in 90% of patients. With the exception of the first episode of uveitis, uveitis and arthritis seem to run different courses; close ophthalmologic scrutiny then should also be maintained during arthritis remission. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/17343317/Prevalence_and_outcome_of_juvenile_idiopathic_arthritis_associated_uveitis_and_relation_to_articular_disease_ L2 - http://www.jrheum.org/cgi/pmidlookup?view=long&amp;pmid=17343317 DB - PRIME DP - Unbound Medicine ER -