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Efficacy of fenbendazole and milbemycin oxime for treating baboons (Papio cynocephalus anubis) infected with Trichuris trichiura.
J Am Assoc Lab Anim Sci. 2007 Mar; 46(2):42-5.JA

Abstract

We evaluated the efficacy of fenbendazole (FBZ) and milbemycin oxime (MO) in the treatment of baboons (Papio cynocephalus anubis) with naturally acquired Trichuris trichiura infection by comparing fecal egg count reduction (FECR) tests. We assigned 7 baboons, each singly housed and confirmed infected with T. trichiura, to treatment groups of FBZ (n=3) or MO (n=3), or as a control (n=1). All (100%) baboons that received FBZ stopped shedding T. trichiura eggs within 6 d of treatment, and fecal egg counts remained negative at 65 d after treatment. Although the number of T. trichiura eggs shed per gram of feces from 2 (67%) baboons decreased significantly after the second treatment with MO, this regimen never totally eliminated eggs of T. trichiura. The results of our study indicate that FBZ was more effective for treating baboons with T. trichiura than was MO.

Authors+Show Affiliations

Department of Veterinary Pathobiology, Center for Veterinary Health Sciences, Oklahoma State University, Stillwater, USA. mason.reichard@okstate.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17343352

Citation

Reichard, Mason V., et al. "Efficacy of Fenbendazole and Milbemycin Oxime for Treating Baboons (Papio Cynocephalus Anubis) Infected With Trichuris Trichiura." Journal of the American Association for Laboratory Animal Science : JAALAS, vol. 46, no. 2, 2007, pp. 42-5.
Reichard MV, Wolf RF, Carey DW, et al. Efficacy of fenbendazole and milbemycin oxime for treating baboons (Papio cynocephalus anubis) infected with Trichuris trichiura. J Am Assoc Lab Anim Sci. 2007;46(2):42-5.
Reichard, M. V., Wolf, R. F., Carey, D. W., Garrett, J. J., & Briscoe, H. A. (2007). Efficacy of fenbendazole and milbemycin oxime for treating baboons (Papio cynocephalus anubis) infected with Trichuris trichiura. Journal of the American Association for Laboratory Animal Science : JAALAS, 46(2), 42-5.
Reichard MV, et al. Efficacy of Fenbendazole and Milbemycin Oxime for Treating Baboons (Papio Cynocephalus Anubis) Infected With Trichuris Trichiura. J Am Assoc Lab Anim Sci. 2007;46(2):42-5. PubMed PMID: 17343352.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of fenbendazole and milbemycin oxime for treating baboons (Papio cynocephalus anubis) infected with Trichuris trichiura. AU - Reichard,Mason V, AU - Wolf,Roman F, AU - Carey,David W, AU - Garrett,Jennifer Jane, AU - Briscoe,Heather A, PY - 2007/3/9/pubmed PY - 2007/6/6/medline PY - 2007/3/9/entrez SP - 42 EP - 5 JF - Journal of the American Association for Laboratory Animal Science : JAALAS JO - J Am Assoc Lab Anim Sci VL - 46 IS - 2 N2 - We evaluated the efficacy of fenbendazole (FBZ) and milbemycin oxime (MO) in the treatment of baboons (Papio cynocephalus anubis) with naturally acquired Trichuris trichiura infection by comparing fecal egg count reduction (FECR) tests. We assigned 7 baboons, each singly housed and confirmed infected with T. trichiura, to treatment groups of FBZ (n=3) or MO (n=3), or as a control (n=1). All (100%) baboons that received FBZ stopped shedding T. trichiura eggs within 6 d of treatment, and fecal egg counts remained negative at 65 d after treatment. Although the number of T. trichiura eggs shed per gram of feces from 2 (67%) baboons decreased significantly after the second treatment with MO, this regimen never totally eliminated eggs of T. trichiura. The results of our study indicate that FBZ was more effective for treating baboons with T. trichiura than was MO. SN - 1559-6109 UR - https://www.unboundmedicine.com/medline/citation/17343352/Efficacy_of_fenbendazole_and_milbemycin_oxime_for_treating_baboons__Papio_cynocephalus_anubis__infected_with_Trichuris_trichiura_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1559-6109&volume=46&issue=2&spage=42&aulast=Reichard DB - PRIME DP - Unbound Medicine ER -