Tags

Type your tag names separated by a space and hit enter

Post-tympanostomy otorrhea: a randomized clinical trial of topical prophylaxis.
Otolaryngol Head Neck Surg 1992; 106(1):34-41OH

Abstract

Myringotomy with the insertion of tympanostomy tubes has become the most frequently performed otolaryngologic procedure, and otorrhea is the most common post-tympanostomy complication. Many otolaryngologists routinely use prophylactic topical antibiotic solutions when performing tympanostomy tube placement. Relatively little has been written regarding early post-tympanostomy otorrhea and scarcely any examining the efficacy of such prophylaxis. The current study is a randomized clinical trial to critically evaluate the efficacy of prophylactic otic drops after tympanostomy tube placement. The ototoxic potential of these solutions, combined with constant pressures to decrease medication expenses and eliminate unnecessary use of antibiotics, makes determination of the shortest effective course of application paramount. Subjects were randomized at the time of surgery into one of three groups: one group received no prophylaxis, a second group received gentamicin otic drops immediately after tympanostomy tube placement in the operating room only, and the third group received an additional 48 hours of drops (4 drops in each ear, three times a day). All patients were seen within 2 weeks postoperatively. An overall early post-tympanostomy otorrhea incidence of 8.7% is documented with 12%, 8.8%, and 5.6% for each study group, respectively. While these findings may suggest possible efficacy of topical prophylaxis, a statistically significant difference between the treatment groups was not proved (p = 0.62). Further analysis by subdivision of the patients, on the basis of middle ear cavity finding at the time of surgery, reveals a highly significant statistical association of the occurrence of post-tympanostomy otorrhea in ears having mucoid effusions (p less than 0.001) as compared to ears without effusion or with serous effusions.(

ABSTRACT

TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Department of Otolaryngology, University of Texas Medical Branch, Galveston 77550.No affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

1734364

Citation

Scott, B A., and C L. Strunk. "Post-tympanostomy Otorrhea: a Randomized Clinical Trial of Topical Prophylaxis." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 106, no. 1, 1992, pp. 34-41.
Scott BA, Strunk CL. Post-tympanostomy otorrhea: a randomized clinical trial of topical prophylaxis. Otolaryngol Head Neck Surg. 1992;106(1):34-41.
Scott, B. A., & Strunk, C. L. (1992). Post-tympanostomy otorrhea: a randomized clinical trial of topical prophylaxis. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 106(1), pp. 34-41.
Scott BA, Strunk CL. Post-tympanostomy Otorrhea: a Randomized Clinical Trial of Topical Prophylaxis. Otolaryngol Head Neck Surg. 1992;106(1):34-41. PubMed PMID: 1734364.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Post-tympanostomy otorrhea: a randomized clinical trial of topical prophylaxis. AU - Scott,B A, AU - Strunk,C L,Jr PY - 1992/1/11/pubmed PY - 2001/3/28/medline PY - 1992/1/11/entrez SP - 34 EP - 41 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 106 IS - 1 N2 - Myringotomy with the insertion of tympanostomy tubes has become the most frequently performed otolaryngologic procedure, and otorrhea is the most common post-tympanostomy complication. Many otolaryngologists routinely use prophylactic topical antibiotic solutions when performing tympanostomy tube placement. Relatively little has been written regarding early post-tympanostomy otorrhea and scarcely any examining the efficacy of such prophylaxis. The current study is a randomized clinical trial to critically evaluate the efficacy of prophylactic otic drops after tympanostomy tube placement. The ototoxic potential of these solutions, combined with constant pressures to decrease medication expenses and eliminate unnecessary use of antibiotics, makes determination of the shortest effective course of application paramount. Subjects were randomized at the time of surgery into one of three groups: one group received no prophylaxis, a second group received gentamicin otic drops immediately after tympanostomy tube placement in the operating room only, and the third group received an additional 48 hours of drops (4 drops in each ear, three times a day). All patients were seen within 2 weeks postoperatively. An overall early post-tympanostomy otorrhea incidence of 8.7% is documented with 12%, 8.8%, and 5.6% for each study group, respectively. While these findings may suggest possible efficacy of topical prophylaxis, a statistically significant difference between the treatment groups was not proved (p = 0.62). Further analysis by subdivision of the patients, on the basis of middle ear cavity finding at the time of surgery, reveals a highly significant statistical association of the occurrence of post-tympanostomy otorrhea in ears having mucoid effusions (p less than 0.001) as compared to ears without effusion or with serous effusions.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0194-5998 UR - https://www.unboundmedicine.com/medline/citation/1734364/Post_tympanostomy_otorrhea:_a_randomized_clinical_trial_of_topical_prophylaxis_ L2 - http://journals.sagepub.com/doi/full/10.1177/019459989210600125?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -