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The effect of pentoxifylline on cochlear blood flow.
Otolaryngol Head Neck Surg. 1992 Jan; 106(1):87-91.OH

Abstract

Pentoxifylline, a phosphodiesterase inhibitor and hemorrheologic agent has been found to increase oxygen delivery to ischemic tissue. Intravenous pentoxifylline was administered to normal guinea pigs in order to assess the effect of pentoxifylline on cochlear blood flow and to elucidate its mechanism of action. Intravenous pentoxifylline was found to acutely increase cochlear blood flow in a dose-dependent manner. In normal animals, the effect appeared strongly related to the rheologic properties of this agent rather than a vasodilative action. Normovolemic hemodilution with 75% dextran resulted in no increase in cochlear blood flow during infusion of pentoxifylline, whereas the application of nitroprusside over the round window failed to abolish the effect of pentoxifylline.

Authors+Show Affiliations

Michigan Ear Institute, Farmington Hills 48334.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1734376

Citation

LaRouere, M J., et al. "The Effect of Pentoxifylline On Cochlear Blood Flow." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 106, no. 1, 1992, pp. 87-91.
LaRouere MJ, Sillman JS, Tsai MT, et al. The effect of pentoxifylline on cochlear blood flow. Otolaryngol Head Neck Surg. 1992;106(1):87-91.
LaRouere, M. J., Sillman, J. S., Tsai, M. T., & Nuttall, A. L. (1992). The effect of pentoxifylline on cochlear blood flow. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 106(1), 87-91.
LaRouere MJ, et al. The Effect of Pentoxifylline On Cochlear Blood Flow. Otolaryngol Head Neck Surg. 1992;106(1):87-91. PubMed PMID: 1734376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of pentoxifylline on cochlear blood flow. AU - LaRouere,M J, AU - Sillman,J S, AU - Tsai,M T, AU - Nuttall,A L, PY - 1992/1/1/pubmed PY - 1992/1/1/medline PY - 1992/1/1/entrez SP - 87 EP - 91 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 106 IS - 1 N2 - Pentoxifylline, a phosphodiesterase inhibitor and hemorrheologic agent has been found to increase oxygen delivery to ischemic tissue. Intravenous pentoxifylline was administered to normal guinea pigs in order to assess the effect of pentoxifylline on cochlear blood flow and to elucidate its mechanism of action. Intravenous pentoxifylline was found to acutely increase cochlear blood flow in a dose-dependent manner. In normal animals, the effect appeared strongly related to the rheologic properties of this agent rather than a vasodilative action. Normovolemic hemodilution with 75% dextran resulted in no increase in cochlear blood flow during infusion of pentoxifylline, whereas the application of nitroprusside over the round window failed to abolish the effect of pentoxifylline. SN - 0194-5998 UR - https://www.unboundmedicine.com/medline/citation/1734376/The_effect_of_pentoxifylline_on_cochlear_blood_flow_ L2 - http://journals.sagepub.com/doi/full/10.1177/019459989210600133?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -