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Clinical outcomes of wide postsurgical lesions in the infected diabetic foot managed with 2 different local treatment regimes compared using a quasi-experimental study design: a preliminary communication.

Abstract

The safety and efficacy of a novel superoxidized solution (Dermacyn Wound Care [DWC], Oculus Innovative Sciences, Petaluma, Calif) was evaluated for the treatment of wide postsurgical infected ulcers of the diabetic foot. A group (group A, n = 18) of patients with diabetes mellitus who had postsurgical lesions > 5 cm(2) without ischemia or infection were recruited consecutively and treated with DWC-saturated dressings. These dressings were renewed once daily and were compared with a group of patients that had been previously treated with diluted povidone iodine (group B, n = 15) using a quasi-experimental study design. Both sets of patients also received standard systemic antibiotic therapy, as per the practice in this center, and local surgical debridement. Patients had weekly assessments until wounds had re-epithelialized completely. Patients in group A had statistically significant shorter healing time and duration of antibiotic therapy and a higher healing rate at 6 months compared with those in group B (p < .01). Recurrence of infection, requirement for debridement procedures, and requirement for minor amputations were significantly less frequent during follow-up in group A patients (p < .05) when compared with those in group B. These preliminary data suggest that DWC used as a wound dressing together with other local and systemic therapies may have a role in reducing healing time as well as complications in patients with diabetes who have postsurgical lesions of the diabetic foot. These data propose the need for a robust controlled study of DWC-saturated dressings to explore its full potential.

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  • Authors+Show Affiliations

    ,

    Diabetic Foot Section, Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy.

    , , , , , , ,

    Source

    MeSH

    Anti-Infective Agents
    Anti-Infective Agents, Local
    Bandages
    Debridement
    Diabetic Foot
    Female
    Humans
    Male
    Middle Aged
    Povidone-Iodine
    Treatment Outcome
    Wound Healing

    Pub Type(s)

    Clinical Trial
    Comparative Study
    Journal Article

    Language

    eng

    PubMed ID

    17344198

    Citation

    Goretti, Chiara, et al. "Clinical Outcomes of Wide Postsurgical Lesions in the Infected Diabetic Foot Managed With 2 Different Local Treatment Regimes Compared Using a Quasi-experimental Study Design: a Preliminary Communication." The International Journal of Lower Extremity Wounds, vol. 6, no. 1, 2007, pp. 22-7.
    Goretti C, Mazzurco S, Nobili LA, et al. Clinical outcomes of wide postsurgical lesions in the infected diabetic foot managed with 2 different local treatment regimes compared using a quasi-experimental study design: a preliminary communication. Int J Low Extrem Wounds. 2007;6(1):22-7.
    Goretti, C., Mazzurco, S., Nobili, L. A., Macchiarini, S., Tedeschi, A., Palumbo, F., ... Piaggesi, A. (2007). Clinical outcomes of wide postsurgical lesions in the infected diabetic foot managed with 2 different local treatment regimes compared using a quasi-experimental study design: a preliminary communication. The International Journal of Lower Extremity Wounds, 6(1), pp. 22-7.
    Goretti C, et al. Clinical Outcomes of Wide Postsurgical Lesions in the Infected Diabetic Foot Managed With 2 Different Local Treatment Regimes Compared Using a Quasi-experimental Study Design: a Preliminary Communication. Int J Low Extrem Wounds. 2007;6(1):22-7. PubMed PMID: 17344198.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Clinical outcomes of wide postsurgical lesions in the infected diabetic foot managed with 2 different local treatment regimes compared using a quasi-experimental study design: a preliminary communication. AU - Goretti,Chiara, AU - Mazzurco,Sabrina, AU - Nobili,Laura Ambrosini, AU - Macchiarini,Silvia, AU - Tedeschi,Anna, AU - Palumbo,Francesca, AU - Scatena,Alessia, AU - Rizzo,Loredana, AU - Piaggesi,Alberto, PY - 2007/3/9/pubmed PY - 2007/4/11/medline PY - 2007/3/9/entrez SP - 22 EP - 7 JF - The international journal of lower extremity wounds JO - Int J Low Extrem Wounds VL - 6 IS - 1 N2 - The safety and efficacy of a novel superoxidized solution (Dermacyn Wound Care [DWC], Oculus Innovative Sciences, Petaluma, Calif) was evaluated for the treatment of wide postsurgical infected ulcers of the diabetic foot. A group (group A, n = 18) of patients with diabetes mellitus who had postsurgical lesions > 5 cm(2) without ischemia or infection were recruited consecutively and treated with DWC-saturated dressings. These dressings were renewed once daily and were compared with a group of patients that had been previously treated with diluted povidone iodine (group B, n = 15) using a quasi-experimental study design. Both sets of patients also received standard systemic antibiotic therapy, as per the practice in this center, and local surgical debridement. Patients had weekly assessments until wounds had re-epithelialized completely. Patients in group A had statistically significant shorter healing time and duration of antibiotic therapy and a higher healing rate at 6 months compared with those in group B (p < .01). Recurrence of infection, requirement for debridement procedures, and requirement for minor amputations were significantly less frequent during follow-up in group A patients (p < .05) when compared with those in group B. These preliminary data suggest that DWC used as a wound dressing together with other local and systemic therapies may have a role in reducing healing time as well as complications in patients with diabetes who have postsurgical lesions of the diabetic foot. These data propose the need for a robust controlled study of DWC-saturated dressings to explore its full potential. SN - 1534-7346 UR - https://www.unboundmedicine.com/medline/citation/17344198/Clinical_outcomes_of_wide_postsurgical_lesions_in_the_infected_diabetic_foot_managed_with_2_different_local_treatment_regimes_compared_using_a_quasi_experimental_study_design:_a_preliminary_communication_ L2 - http://journals.sagepub.com/doi/full/10.1177/1534734606298543?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -