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Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration.
Am J Clin Nutr. 2007 Mar; 85(3):762-9.AJ

Abstract

BACKGROUND

Low dietary intakes and low plasma concentrations of lutein and zeaxanthin are associated with an increased risk of age-related macular degeneration (AMD). No studies have challenged AMD patients with a diet high in lutein and zeaxanthin.

OBJECTIVE

The objective was to examine the effect of diets low or high in lutein and zeaxanthin on plasma carotenoids and their transport in AMD patients.

DESIGN

Seven AMD patients and 5 control subjects were fed a low-lutein, low-zeaxanthin diet (approximately 1.1 mg/d) for 2 wk, which was followed by a high-lutein, high-zeaxanthin diet (approximately 11 mg/d) for 4 wk. Ten subjects continued the diet for 8 wk. Plasma and lipoprotein carotenoids were measured by HPLC.

RESULTS

The high-lutein, high-zeaxanthin diet resulted in 2- to 3-fold increases in plasma concentrations of lutein and zeaxanthin and other carotenoids, except lycopene, in the AMD patients and the control subjects. With this diet, 52% of the lutein and 44% of the zeaxanthin were transported by HDL; approximately 22% of lutein and zeaxanthin was transported by LDL. Only 20-25% of alpha-carotene, beta-carotene, and lycopene was transported by HDL; 50-57% was transported by LDL.

CONCLUSIONS

The AMD patients and control subjects responded similarly to a diet high in lutein and zeaxanthin; plasma carotenoid concentrations increased greatly in both groups, and the transport of carotenoids by lipoproteins was not significantly different between the groups. This finding suggests that abnormalities in the metabolism of lutein and zeaxanthin in AMD may reside in the uptake of lutein and zeaxanthin from the plasma and transport into the retina.

Authors+Show Affiliations

Department of Medicine, Oregon Health and Science University, Portland, OR 97239-3098, USA. wangwe@ohsu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17344498

Citation

Wang, Wei, et al. "Effect of Dietary Lutein and Zeaxanthin On Plasma Carotenoids and Their Transport in Lipoproteins in Age-related Macular Degeneration." The American Journal of Clinical Nutrition, vol. 85, no. 3, 2007, pp. 762-9.
Wang W, Connor SL, Johnson EJ, et al. Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration. Am J Clin Nutr. 2007;85(3):762-9.
Wang, W., Connor, S. L., Johnson, E. J., Klein, M. L., Hughes, S., & Connor, W. E. (2007). Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration. The American Journal of Clinical Nutrition, 85(3), 762-9.
Wang W, et al. Effect of Dietary Lutein and Zeaxanthin On Plasma Carotenoids and Their Transport in Lipoproteins in Age-related Macular Degeneration. Am J Clin Nutr. 2007;85(3):762-9. PubMed PMID: 17344498.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration. AU - Wang,Wei, AU - Connor,Sonja L, AU - Johnson,Elizabeth J, AU - Klein,Michael L, AU - Hughes,Shannon, AU - Connor,William E, PY - 2007/3/9/pubmed PY - 2007/4/27/medline PY - 2007/3/9/entrez SP - 762 EP - 9 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 85 IS - 3 N2 - BACKGROUND: Low dietary intakes and low plasma concentrations of lutein and zeaxanthin are associated with an increased risk of age-related macular degeneration (AMD). No studies have challenged AMD patients with a diet high in lutein and zeaxanthin. OBJECTIVE: The objective was to examine the effect of diets low or high in lutein and zeaxanthin on plasma carotenoids and their transport in AMD patients. DESIGN: Seven AMD patients and 5 control subjects were fed a low-lutein, low-zeaxanthin diet (approximately 1.1 mg/d) for 2 wk, which was followed by a high-lutein, high-zeaxanthin diet (approximately 11 mg/d) for 4 wk. Ten subjects continued the diet for 8 wk. Plasma and lipoprotein carotenoids were measured by HPLC. RESULTS: The high-lutein, high-zeaxanthin diet resulted in 2- to 3-fold increases in plasma concentrations of lutein and zeaxanthin and other carotenoids, except lycopene, in the AMD patients and the control subjects. With this diet, 52% of the lutein and 44% of the zeaxanthin were transported by HDL; approximately 22% of lutein and zeaxanthin was transported by LDL. Only 20-25% of alpha-carotene, beta-carotene, and lycopene was transported by HDL; 50-57% was transported by LDL. CONCLUSIONS: The AMD patients and control subjects responded similarly to a diet high in lutein and zeaxanthin; plasma carotenoid concentrations increased greatly in both groups, and the transport of carotenoids by lipoproteins was not significantly different between the groups. This finding suggests that abnormalities in the metabolism of lutein and zeaxanthin in AMD may reside in the uptake of lutein and zeaxanthin from the plasma and transport into the retina. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/17344498/Effect_of_dietary_lutein_and_zeaxanthin_on_plasma_carotenoids_and_their_transport_in_lipoproteins_in_age_related_macular_degeneration_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/85.3.762 DB - PRIME DP - Unbound Medicine ER -