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Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age.
Am J Clin Nutr. 2007 Mar; 85(3):788-95.AJ

Abstract

BACKGROUND

Vitamin D deficiency and asthma are common at higher latitudes. Although vitamin D has important immunologic effects, its relation with asthma is unknown.

OBJECTIVE

We hypothesized that a higher maternal intake of vitamin D during pregnancy is associated with a lower risk of recurrent wheeze in children at 3 y of age.

DESIGN

The participants were 1194 mother-child pairs in Project Viva-a prospective prebirth cohort study in Massachusetts. We assessed the maternal intake of vitamin D during pregnancy from a validated food-frequency questionnaire. The primary outcome was recurrent wheeze, ie, a positive asthma predictive index (>or=2 wheezing attacks among children with a personal diagnosis of eczema or a parental history of asthma).

RESULTS

The mean (+/-SD) total vitamin D intake during pregnancy was 548 +/- 167 IU/d. By age 3 y, 186 children (16%) had recurrent wheeze. Compared with mothers in the lowest quartile of daily intake (median: 356 IU), those in the highest quartile (724 IU) had a lower risk of having a child with recurrent wheeze [odds ratio (OR): 0.39; 95% CI: 0.25, 0.62; P for trend < 0.001]. A 100-IU increase in vitamin D intake was associated with lower risk (OR: 0.81; 95% CI: 0.74, 0.89), regardless of whether vitamin D was from the diet (OR: 0.81; 95% CI: 0.69, 0.96) or supplements (OR: 0.82; 95% CI: 0.73, 0.92). Adjustment for 12 potential confounders, including maternal intake of other dietary factors, did not change the results.

CONCLUSION

In the northeastern United States, a higher maternal intake of vitamin D during pregnancy may decrease the risk of recurrent wheeze in early childhood.

Authors+Show Affiliations

Center for D-receptor Activation Research, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. ccamargo@partners.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17344501

Citation

Camargo, Carlos A., et al. "Maternal Intake of Vitamin D During Pregnancy and Risk of Recurrent Wheeze in Children at 3 Y of Age." The American Journal of Clinical Nutrition, vol. 85, no. 3, 2007, pp. 788-95.
Camargo CA, Rifas-Shiman SL, Litonjua AA, et al. Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. Am J Clin Nutr. 2007;85(3):788-95.
Camargo, C. A., Rifas-Shiman, S. L., Litonjua, A. A., Rich-Edwards, J. W., Weiss, S. T., Gold, D. R., Kleinman, K., & Gillman, M. W. (2007). Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. The American Journal of Clinical Nutrition, 85(3), 788-95.
Camargo CA, et al. Maternal Intake of Vitamin D During Pregnancy and Risk of Recurrent Wheeze in Children at 3 Y of Age. Am J Clin Nutr. 2007;85(3):788-95. PubMed PMID: 17344501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal intake of vitamin D during pregnancy and risk of recurrent wheeze in children at 3 y of age. AU - Camargo,Carlos A,Jr AU - Rifas-Shiman,Sheryl L, AU - Litonjua,Augusto A, AU - Rich-Edwards,Janet W, AU - Weiss,Scott T, AU - Gold,Diane R, AU - Kleinman,Ken, AU - Gillman,Matthew W, PY - 2007/3/9/pubmed PY - 2007/4/27/medline PY - 2007/3/9/entrez SP - 788 EP - 95 JF - The American journal of clinical nutrition JO - Am J Clin Nutr VL - 85 IS - 3 N2 - BACKGROUND: Vitamin D deficiency and asthma are common at higher latitudes. Although vitamin D has important immunologic effects, its relation with asthma is unknown. OBJECTIVE: We hypothesized that a higher maternal intake of vitamin D during pregnancy is associated with a lower risk of recurrent wheeze in children at 3 y of age. DESIGN: The participants were 1194 mother-child pairs in Project Viva-a prospective prebirth cohort study in Massachusetts. We assessed the maternal intake of vitamin D during pregnancy from a validated food-frequency questionnaire. The primary outcome was recurrent wheeze, ie, a positive asthma predictive index (>or=2 wheezing attacks among children with a personal diagnosis of eczema or a parental history of asthma). RESULTS: The mean (+/-SD) total vitamin D intake during pregnancy was 548 +/- 167 IU/d. By age 3 y, 186 children (16%) had recurrent wheeze. Compared with mothers in the lowest quartile of daily intake (median: 356 IU), those in the highest quartile (724 IU) had a lower risk of having a child with recurrent wheeze [odds ratio (OR): 0.39; 95% CI: 0.25, 0.62; P for trend < 0.001]. A 100-IU increase in vitamin D intake was associated with lower risk (OR: 0.81; 95% CI: 0.74, 0.89), regardless of whether vitamin D was from the diet (OR: 0.81; 95% CI: 0.69, 0.96) or supplements (OR: 0.82; 95% CI: 0.73, 0.92). Adjustment for 12 potential confounders, including maternal intake of other dietary factors, did not change the results. CONCLUSION: In the northeastern United States, a higher maternal intake of vitamin D during pregnancy may decrease the risk of recurrent wheeze in early childhood. SN - 0002-9165 UR - https://www.unboundmedicine.com/medline/citation/17344501/Maternal_intake_of_vitamin_D_during_pregnancy_and_risk_of_recurrent_wheeze_in_children_at_3_y_of_age_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.1093/ajcn/85.3.788 DB - PRIME DP - Unbound Medicine ER -