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Enantioselective and diastereoselective Michael addition of ketone/aldehyde to trans-nitroolefins catalyzed by a novel chiral pyrrolidine-thiourea.
Chirality. 2007 May 05; 19(4):307-12.C

Abstract

The direct Michael addition reaction of cyclohexanone/aliphatic aldehydes with nitroolefins, catalyzed by a novel chiral pyrrolidine-thiourea catalyst 1a, is described. The desired 1,4-adducts were obtained in moderate yields with enantioselectivities up to 99% ee and dr up to 99:1 of the syn product.

Authors+Show Affiliations

Shen Z
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215123, China.
Zhang Y
No affiliation info available
Jiao C
No affiliation info available
Li B
No affiliation info available
Ding J
No affiliation info available
Zhang Y
No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17345560

Citation

Shen, Zongxuan, et al. "Enantioselective and Diastereoselective Michael Addition of Ketone/aldehyde to Trans-nitroolefins Catalyzed By a Novel Chiral Pyrrolidine-thiourea." Chirality, vol. 19, no. 4, 2007, pp. 307-12.
Shen Z, Zhang Y, Jiao C, et al. Enantioselective and diastereoselective Michael addition of ketone/aldehyde to trans-nitroolefins catalyzed by a novel chiral pyrrolidine-thiourea. Chirality. 2007;19(4):307-12.
Shen, Z., Zhang, Y., Jiao, C., Li, B., Ding, J., & Zhang, Y. (2007). Enantioselective and diastereoselective Michael addition of ketone/aldehyde to trans-nitroolefins catalyzed by a novel chiral pyrrolidine-thiourea. Chirality, 19(4), 307-12.
Shen Z, et al. Enantioselective and Diastereoselective Michael Addition of Ketone/aldehyde to Trans-nitroolefins Catalyzed By a Novel Chiral Pyrrolidine-thiourea. Chirality. 2007 May 5;19(4):307-12. PubMed PMID: 17345560.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enantioselective and diastereoselective Michael addition of ketone/aldehyde to trans-nitroolefins catalyzed by a novel chiral pyrrolidine-thiourea. AU - Shen,Zongxuan, AU - Zhang,Yongqiang, AU - Jiao,Chongjun, AU - Li,Bin, AU - Ding,Juan, AU - Zhang,Yawen, PY - 2007/3/9/pubmed PY - 2007/3/9/medline PY - 2007/3/9/entrez SP - 307 EP - 12 JF - Chirality JO - Chirality VL - 19 IS - 4 N2 - The direct Michael addition reaction of cyclohexanone/aliphatic aldehydes with nitroolefins, catalyzed by a novel chiral pyrrolidine-thiourea catalyst 1a, is described. The desired 1,4-adducts were obtained in moderate yields with enantioselectivities up to 99% ee and dr up to 99:1 of the syn product. SN - 0899-0042 UR - https://www.unboundmedicine.com/medline/citation/17345560/Enantioselective_and_diastereoselective_Michael_addition_of_ketone/aldehyde_to_trans_nitroolefins_catalyzed_by_a_novel_chiral_pyrrolidine_thiourea_ L2 - https://doi.org/10.1002/chir.20382 DB - PRIME DP - Unbound Medicine ER -
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