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[The plasma levels and diagnostic utility of granulocyte colony stimulating factor (G-CSF) and macrophage - colony stimulating factor (M-CSF) in ovarian cancer patients].
Pol Merkur Lekarski. 2006 Nov; 21(125):465-8.PM

Abstract

G-CSF and M-CSF are of the glycoproteins called colony-stimulating factors (CSFs). Some clinical investigations have shown an autologous production of G-CSF and M-CSF in various human cell lines in vitro and by tumors in vivo.

AIM OF STUDY

We have investigated the plasma levels and diagnostic utility of G-CSF M-CSF and commonly accepted tumor marker, such as CA 125 in ovarian cancer patients before surgery and healthy subjects.

MATERIAL AND METHODS

We tested 30 patients with ovarian cancer and 30 healthy women (control group). G-CSF and M-CSF were determined using enzyme-linked immunosorbent assay (ELISA), CA 125 was measured by microparticle enzyme immunoassay (MEIA).

RESULTS

G-CSF, M-CSF and CA 125 plasma levels were significantly higher in ovarian cancer patients compared to the control group. The diagnostic sensitivity of M-CSF was higher than for G-CSF and CA 125 (57%, 50% i 53%, respectively). The diagnostic specificity was high and equal for all tested parameters (93%). Positive predictive value was higher for M-CSF and CA 125 (equal 89%). Negative predictive value was the highest for M-CSF in comparison to G-C.SF and CA 125 (68%, 65%, 66,7%, respectively).

CONCLUSIONS

Our study suggests that especially M-CSF can be clinically useful in diagnostic ovarian cancer, but further investigation and confirmation by a prospective study is necessary.

Authors+Show Affiliations

Department of Biochemical Diagnostics, Medical University of Białystok, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

pol

PubMed ID

17345841

Citation

ławicki, Sławomir, et al. "[The Plasma Levels and Diagnostic Utility of Granulocyte Colony Stimulating Factor (G-CSF) and Macrophage - Colony Stimulating Factor (M-CSF) in Ovarian Cancer Patients]." Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, vol. 21, no. 125, 2006, pp. 465-8.
ławicki S, Czygier M, Gacuta-Szumarska E, et al. [The plasma levels and diagnostic utility of granulocyte colony stimulating factor (G-CSF) and macrophage - colony stimulating factor (M-CSF) in ovarian cancer patients]. Pol Merkur Lekarski. 2006;21(125):465-8.
ławicki, S., Czygier, M., Gacuta-Szumarska, E., Knapp, P., & Szmitkowski, M. (2006). [The plasma levels and diagnostic utility of granulocyte colony stimulating factor (G-CSF) and macrophage - colony stimulating factor (M-CSF) in ovarian cancer patients]. Polski Merkuriusz Lekarski : Organ Polskiego Towarzystwa Lekarskiego, 21(125), 465-8.
ławicki S, et al. [The Plasma Levels and Diagnostic Utility of Granulocyte Colony Stimulating Factor (G-CSF) and Macrophage - Colony Stimulating Factor (M-CSF) in Ovarian Cancer Patients]. Pol Merkur Lekarski. 2006;21(125):465-8. PubMed PMID: 17345841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The plasma levels and diagnostic utility of granulocyte colony stimulating factor (G-CSF) and macrophage - colony stimulating factor (M-CSF) in ovarian cancer patients]. AU - ławicki,Sławomir, AU - Czygier,Małgorzata, AU - Gacuta-Szumarska,Ewa, AU - Knapp,Paweł, AU - Szmitkowski,Maciej, PY - 2007/3/10/pubmed PY - 2007/5/2/medline PY - 2007/3/10/entrez SP - 465 EP - 8 JF - Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego JO - Pol Merkur Lekarski VL - 21 IS - 125 N2 - UNLABELLED: G-CSF and M-CSF are of the glycoproteins called colony-stimulating factors (CSFs). Some clinical investigations have shown an autologous production of G-CSF and M-CSF in various human cell lines in vitro and by tumors in vivo. AIM OF STUDY: We have investigated the plasma levels and diagnostic utility of G-CSF M-CSF and commonly accepted tumor marker, such as CA 125 in ovarian cancer patients before surgery and healthy subjects. MATERIAL AND METHODS: We tested 30 patients with ovarian cancer and 30 healthy women (control group). G-CSF and M-CSF were determined using enzyme-linked immunosorbent assay (ELISA), CA 125 was measured by microparticle enzyme immunoassay (MEIA). RESULTS: G-CSF, M-CSF and CA 125 plasma levels were significantly higher in ovarian cancer patients compared to the control group. The diagnostic sensitivity of M-CSF was higher than for G-CSF and CA 125 (57%, 50% i 53%, respectively). The diagnostic specificity was high and equal for all tested parameters (93%). Positive predictive value was higher for M-CSF and CA 125 (equal 89%). Negative predictive value was the highest for M-CSF in comparison to G-C.SF and CA 125 (68%, 65%, 66,7%, respectively). CONCLUSIONS: Our study suggests that especially M-CSF can be clinically useful in diagnostic ovarian cancer, but further investigation and confirmation by a prospective study is necessary. SN - 1426-9686 UR - https://www.unboundmedicine.com/medline/citation/17345841/[The_plasma_levels_and_diagnostic_utility_of_granulocyte_colony_stimulating_factor__G_CSF__and_macrophage___colony_stimulating_factor__M_CSF__in_ovarian_cancer_patients]_ L2 - http://www.diseaseinfosearch.org/result/5504 DB - PRIME DP - Unbound Medicine ER -