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Epicardial adipose tissue is related to carotid intima-media thickness and visceral adiposity in HIV-infected patients with highly active antiretroviral therapy-associated metabolic syndrome.
Curr HIV Res 2007; 5(2):275-9CH

Abstract

BACKGROUND

High cardiovascular risk and accelerated atherosclerosis are associated with human immunodeficiency virus (HIV). Recently, the use of highly active antiretroviral therapy (HAART) for the treatment of HIV infection is correlated with the development of HAART-associated metabolic syndrome and lipodystrophy (LDS). Detection of epicardial fat thickness, new index of visceral adiposity in non HIV-infected patients, might be important as diagnostic tool in HIV-infected patients on HAART.

OBJECTIVE

Primary objective of this study was to evaluate whether echocardiographic epicardial adipose tissue is related to visceral adipose tissue (VAT) and Carotid Intima-Media Thickness (IMT), index of atherosclerosis in HIV-infected patients on HAART with LDS.

DESIGN

We studied 60 consecutive HIV-infected subjects with HAART-associated metabolic syndrome and LDS and 45 HIV-infected subjects on HAART without LDS.

MAIN OUTCOMES MEASURES

Epicardial fat thickness and IMT were measured by ultrasonography in both study and control groups. Magnetic resonance imaging (MRI) was used to calculate VAT in HIV-infected subjects on HAART with LDS.

RESULTS

Epicardial adipose tissue thickness showed an excellent correlation with MRI-VAT (r=0.85; P<0.001) and IMT (r=0.78;P<0.001) in HIV-infected patients on HAART-with LDS. Multiple regression analysis showed that epicardial fat thickness was best predicted by MRI-VAT and IMT (R2=0.57, p<0.001 and p<0.01, respectively). HIV-infected patients with HAART-associated metabolic syndrome and LDS showed higher epicardial fat thickness and IMT (8 vs 6.5 mm; 0.71 vs 0.66 mm, respectively, p<0.01 for both) than HIV-infected subjects on HAART without LDS.

CONCLUSION

Echocardiographic assessment of epicardial fat may have the potential to be a simple and reliable marker of visceral adiposity and increased cardiovascular risk in HIV-infected patients with HAART-associated metabolic syndrome and LDS.

Authors+Show Affiliations

Cardiovascular Obesity Research and Management at the Michael G deGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada. gianluca@cardio.on.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17346142

Citation

Iacobellis, Gianluca, et al. "Epicardial Adipose Tissue Is Related to Carotid Intima-media Thickness and Visceral Adiposity in HIV-infected Patients With Highly Active Antiretroviral Therapy-associated Metabolic Syndrome." Current HIV Research, vol. 5, no. 2, 2007, pp. 275-9.
Iacobellis G, Sharma AM, Pellicelli AM, et al. Epicardial adipose tissue is related to carotid intima-media thickness and visceral adiposity in HIV-infected patients with highly active antiretroviral therapy-associated metabolic syndrome. Curr HIV Res. 2007;5(2):275-9.
Iacobellis, G., Sharma, A. M., Pellicelli, A. M., Grisorio, B., Barbarini, G., & Barbaro, G. (2007). Epicardial adipose tissue is related to carotid intima-media thickness and visceral adiposity in HIV-infected patients with highly active antiretroviral therapy-associated metabolic syndrome. Current HIV Research, 5(2), pp. 275-9.
Iacobellis G, et al. Epicardial Adipose Tissue Is Related to Carotid Intima-media Thickness and Visceral Adiposity in HIV-infected Patients With Highly Active Antiretroviral Therapy-associated Metabolic Syndrome. Curr HIV Res. 2007;5(2):275-9. PubMed PMID: 17346142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epicardial adipose tissue is related to carotid intima-media thickness and visceral adiposity in HIV-infected patients with highly active antiretroviral therapy-associated metabolic syndrome. AU - Iacobellis,Gianluca, AU - Sharma,Arya M, AU - Pellicelli,Adriano M, AU - Grisorio,Benvenuto, AU - Barbarini,Giorgio, AU - Barbaro,Giuseppe, PY - 2007/3/10/pubmed PY - 2007/3/28/medline PY - 2007/3/10/entrez SP - 275 EP - 9 JF - Current HIV research JO - Curr. HIV Res. VL - 5 IS - 2 N2 - BACKGROUND: High cardiovascular risk and accelerated atherosclerosis are associated with human immunodeficiency virus (HIV). Recently, the use of highly active antiretroviral therapy (HAART) for the treatment of HIV infection is correlated with the development of HAART-associated metabolic syndrome and lipodystrophy (LDS). Detection of epicardial fat thickness, new index of visceral adiposity in non HIV-infected patients, might be important as diagnostic tool in HIV-infected patients on HAART. OBJECTIVE: Primary objective of this study was to evaluate whether echocardiographic epicardial adipose tissue is related to visceral adipose tissue (VAT) and Carotid Intima-Media Thickness (IMT), index of atherosclerosis in HIV-infected patients on HAART with LDS. DESIGN: We studied 60 consecutive HIV-infected subjects with HAART-associated metabolic syndrome and LDS and 45 HIV-infected subjects on HAART without LDS. MAIN OUTCOMES MEASURES: Epicardial fat thickness and IMT were measured by ultrasonography in both study and control groups. Magnetic resonance imaging (MRI) was used to calculate VAT in HIV-infected subjects on HAART with LDS. RESULTS: Epicardial adipose tissue thickness showed an excellent correlation with MRI-VAT (r=0.85; P<0.001) and IMT (r=0.78;P<0.001) in HIV-infected patients on HAART-with LDS. Multiple regression analysis showed that epicardial fat thickness was best predicted by MRI-VAT and IMT (R2=0.57, p<0.001 and p<0.01, respectively). HIV-infected patients with HAART-associated metabolic syndrome and LDS showed higher epicardial fat thickness and IMT (8 vs 6.5 mm; 0.71 vs 0.66 mm, respectively, p<0.01 for both) than HIV-infected subjects on HAART without LDS. CONCLUSION: Echocardiographic assessment of epicardial fat may have the potential to be a simple and reliable marker of visceral adiposity and increased cardiovascular risk in HIV-infected patients with HAART-associated metabolic syndrome and LDS. SN - 1873-4251 UR - https://www.unboundmedicine.com/medline/citation/17346142/Epicardial_adipose_tissue_is_related_to_carotid_intima_media_thickness_and_visceral_adiposity_in_HIV_infected_patients_with_highly_active_antiretroviral_therapy_associated_metabolic_syndrome_ L2 - http://www.eurekaselect.com/89905/article DB - PRIME DP - Unbound Medicine ER -