Tags

Type your tag names separated by a space and hit enter

Isolation and genetic analysis of human origin H1N1 and H3N2 influenza viruses from pigs in China.
Biochem Biophys Res Commun 2007; 356(1):91-6BB

Abstract

Influenza A viruses of subtypes H1N1 and H3N2 have been reported widely in pigs, associated with clinical disease. These mainly include classical swine H1N1, avian-like H1N1, and human-like or avian-like H3N2 viruses. From 2005 to 2006, we carried out swine influenza virus surveillance in eight provinces of China. Here we report, for the first time, the isolation and genetic analysis of a human-like influenza H1N1 virus from a pig in a farm of Guangdong province of southern China, a host suspected to generate new pandemic strains through genetic reassortment. Each of the eight gene segments is of human origin. Phylogenetic analysis indicates that these genes form a human lineage, suggesting that this virus is the descendant of recent human H1N1 influenza viruses. In addition, four swine H3N2 viruses were also isolated. The three H3N2 viruses from Guangdong province are descendants of recent human viruses, while an H3N2 virus from Heilongjiang province derives from early human viruses. Isolation and genetic analysis of human H1N1 and H3N2 influenza viruses from pigs in China provides further evidence about the interspecies transmission of human influenza viruses to pigs and emphasizes the importance of reinforcing swine influenza virus surveillance.

Authors+Show Affiliations

National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17346674

Citation

Yu, Hai, et al. "Isolation and Genetic Analysis of Human Origin H1N1 and H3N2 Influenza Viruses From Pigs in China." Biochemical and Biophysical Research Communications, vol. 356, no. 1, 2007, pp. 91-6.
Yu H, Zhang GH, Hua RH, et al. Isolation and genetic analysis of human origin H1N1 and H3N2 influenza viruses from pigs in China. Biochem Biophys Res Commun. 2007;356(1):91-6.
Yu, H., Zhang, G. H., Hua, R. H., Zhang, Q., Liu, T. Q., Liao, M., & Tong, G. Z. (2007). Isolation and genetic analysis of human origin H1N1 and H3N2 influenza viruses from pigs in China. Biochemical and Biophysical Research Communications, 356(1), pp. 91-6.
Yu H, et al. Isolation and Genetic Analysis of Human Origin H1N1 and H3N2 Influenza Viruses From Pigs in China. Biochem Biophys Res Commun. 2007 Apr 27;356(1):91-6. PubMed PMID: 17346674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Isolation and genetic analysis of human origin H1N1 and H3N2 influenza viruses from pigs in China. AU - Yu,Hai, AU - Zhang,Gui-Hong, AU - Hua,Rong-Hong, AU - Zhang,Qiang, AU - Liu,Tian-Qiang, AU - Liao,Ming, AU - Tong,Guang-Zhi, Y1 - 2007/02/27/ PY - 2007/02/12/received PY - 2007/02/16/accepted PY - 2007/3/10/pubmed PY - 2007/6/21/medline PY - 2007/3/10/entrez SP - 91 EP - 6 JF - Biochemical and biophysical research communications JO - Biochem. Biophys. Res. Commun. VL - 356 IS - 1 N2 - Influenza A viruses of subtypes H1N1 and H3N2 have been reported widely in pigs, associated with clinical disease. These mainly include classical swine H1N1, avian-like H1N1, and human-like or avian-like H3N2 viruses. From 2005 to 2006, we carried out swine influenza virus surveillance in eight provinces of China. Here we report, for the first time, the isolation and genetic analysis of a human-like influenza H1N1 virus from a pig in a farm of Guangdong province of southern China, a host suspected to generate new pandemic strains through genetic reassortment. Each of the eight gene segments is of human origin. Phylogenetic analysis indicates that these genes form a human lineage, suggesting that this virus is the descendant of recent human H1N1 influenza viruses. In addition, four swine H3N2 viruses were also isolated. The three H3N2 viruses from Guangdong province are descendants of recent human viruses, while an H3N2 virus from Heilongjiang province derives from early human viruses. Isolation and genetic analysis of human H1N1 and H3N2 influenza viruses from pigs in China provides further evidence about the interspecies transmission of human influenza viruses to pigs and emphasizes the importance of reinforcing swine influenza virus surveillance. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/17346674/Isolation_and_genetic_analysis_of_human_origin_H1N1_and_H3N2_influenza_viruses_from_pigs_in_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(07)00380-4 DB - PRIME DP - Unbound Medicine ER -