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Glycyrrhizin protection against 3-morpholinosydnonime-induced mitochondrial dysfunction and cell death in lung epithelial cells.
Life Sci. 2007 Apr 17; 80(19):1759-67.LS

Abstract

The present study was designed to assess the preventive effect of licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid against mitochondrial damage and cell death in lung epithelial cells exposed to 3-morpholinosydnonime, a donor of nitric oxide and superoxide. Treatment of lung epithelial cells with 3-morpholinosydnonime resulted in the nuclear damage, decrease in the mitochondrial transmembrane potential, cytosolic accumulation of cytochrome c, activation of caspase-3, increase in the formation of reactive oxygen species and depletion of GSH. Treatment of glycyrrhizin and 18beta-glycyrrhetinic acid attenuated the 3-morpholinosydnonime-induced mitochondrial damage, formation of reactive oxygen species and GSH depletion and revealed a maximal inhibitory effect at 10 and 1 muM, respectively; beyond these concentrations the inhibitory effect declined. Melatonin, carboxy-PTIO, rutin and uric acid reduced the 3-morpholinosydnonime-induced cell death. The results show that glycyrrhizin and 18beta-glycyrrhetinic acid seem to prevent the toxic effect of 3-morpholinosydnonime against lung epithelial cells by suppressing the mitochondrial permeability transition that leads to the release of cytochrome c and activation of caspase-3. The preventive effect may be ascribed to the inhibitory action on the formation of reactive oxygen species and depletion of GSH. The findings suggest that licorice compounds seem to prevent the nitrogen species-mediated lung cell damage.

Authors+Show Affiliations

Department of Pharmacology, College of Medicine, Chung-Ang University, Seoul 156-756, South Korea. leecs@cau.ac.krNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17346752

Citation

Lee, Chung Soo, et al. "Glycyrrhizin Protection Against 3-morpholinosydnonime-induced Mitochondrial Dysfunction and Cell Death in Lung Epithelial Cells." Life Sciences, vol. 80, no. 19, 2007, pp. 1759-67.
Lee CS, Kim YJ, Han ES. Glycyrrhizin protection against 3-morpholinosydnonime-induced mitochondrial dysfunction and cell death in lung epithelial cells. Life Sci. 2007;80(19):1759-67.
Lee, C. S., Kim, Y. J., & Han, E. S. (2007). Glycyrrhizin protection against 3-morpholinosydnonime-induced mitochondrial dysfunction and cell death in lung epithelial cells. Life Sciences, 80(19), 1759-67.
Lee CS, Kim YJ, Han ES. Glycyrrhizin Protection Against 3-morpholinosydnonime-induced Mitochondrial Dysfunction and Cell Death in Lung Epithelial Cells. Life Sci. 2007 Apr 17;80(19):1759-67. PubMed PMID: 17346752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glycyrrhizin protection against 3-morpholinosydnonime-induced mitochondrial dysfunction and cell death in lung epithelial cells. AU - Lee,Chung Soo, AU - Kim,Yun Jeong, AU - Han,Eun Sook, Y1 - 2007/02/11/ PY - 2006/10/28/received PY - 2007/01/21/revised PY - 2007/02/05/accepted PY - 2007/3/10/pubmed PY - 2007/6/15/medline PY - 2007/3/10/entrez SP - 1759 EP - 67 JF - Life sciences JO - Life Sci VL - 80 IS - 19 N2 - The present study was designed to assess the preventive effect of licorice compounds glycyrrhizin and 18beta-glycyrrhetinic acid against mitochondrial damage and cell death in lung epithelial cells exposed to 3-morpholinosydnonime, a donor of nitric oxide and superoxide. Treatment of lung epithelial cells with 3-morpholinosydnonime resulted in the nuclear damage, decrease in the mitochondrial transmembrane potential, cytosolic accumulation of cytochrome c, activation of caspase-3, increase in the formation of reactive oxygen species and depletion of GSH. Treatment of glycyrrhizin and 18beta-glycyrrhetinic acid attenuated the 3-morpholinosydnonime-induced mitochondrial damage, formation of reactive oxygen species and GSH depletion and revealed a maximal inhibitory effect at 10 and 1 muM, respectively; beyond these concentrations the inhibitory effect declined. Melatonin, carboxy-PTIO, rutin and uric acid reduced the 3-morpholinosydnonime-induced cell death. The results show that glycyrrhizin and 18beta-glycyrrhetinic acid seem to prevent the toxic effect of 3-morpholinosydnonime against lung epithelial cells by suppressing the mitochondrial permeability transition that leads to the release of cytochrome c and activation of caspase-3. The preventive effect may be ascribed to the inhibitory action on the formation of reactive oxygen species and depletion of GSH. The findings suggest that licorice compounds seem to prevent the nitrogen species-mediated lung cell damage. SN - 0024-3205 UR - https://www.unboundmedicine.com/medline/citation/17346752/Glycyrrhizin_protection_against_3_morpholinosydnonime_induced_mitochondrial_dysfunction_and_cell_death_in_lung_epithelial_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0024-3205(07)00155-5 DB - PRIME DP - Unbound Medicine ER -