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Determination of 4-alkyl 2,5 dimethoxy-amphetamine derivatives by capillary electrophoresis with mass spectrometry detection from urine samples.
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 01; 852(1-2):578-81.JC

Abstract

The methylenedioxy-derivatives of amphetamine represent the largest group of designer drugs. The 4-methyl (DOM), -ethyl (DOET) and -propyl (DOPR) derivatives of 2,5-dimethoxy-amphetamine (2,5-DMA) were found to possess quite similar serotonin receptor affinities [R.A. Glennon, D.L. Doot, R. Young, Pharmacol. Biochem. Behav. 14 (1981) 287.]. This paper describes a method to screen for and quantify DOM, DOET and DOPR in urine samples, using capillary electrophoresis coupled to electrospray ionisation-mass spectrometry (CE-ESI-MS). Prior to CE-MS analysis, a simple solid-phase extraction (SPE) was used for sample cleanup. The method was validated according to international guidelines. Data for accuracy and precision were within required limits. Calibration curves were generated ranging from 10 to 1000 ng/mL and correlation coefficients always exceeded 0.996.

Authors+Show Affiliations

Dipartimento Farmaco Chimico Tossicologico, Università di Sassari, via Muroni 23/a, 07100 Sassari, Italy.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Validation Study

Language

eng

PubMed ID

17347059

Citation

Nieddu, Maria, et al. "Determination of 4-alkyl 2,5 Dimethoxy-amphetamine Derivatives By Capillary Electrophoresis With Mass Spectrometry Detection From Urine Samples." Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, vol. 852, no. 1-2, 2007, pp. 578-81.
Nieddu M, Boatto G, Dessì G. Determination of 4-alkyl 2,5 dimethoxy-amphetamine derivatives by capillary electrophoresis with mass spectrometry detection from urine samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2007;852(1-2):578-81.
Nieddu, M., Boatto, G., & Dessì, G. (2007). Determination of 4-alkyl 2,5 dimethoxy-amphetamine derivatives by capillary electrophoresis with mass spectrometry detection from urine samples. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 852(1-2), 578-81.
Nieddu M, Boatto G, Dessì G. Determination of 4-alkyl 2,5 Dimethoxy-amphetamine Derivatives By Capillary Electrophoresis With Mass Spectrometry Detection From Urine Samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 1;852(1-2):578-81. PubMed PMID: 17347059.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Determination of 4-alkyl 2,5 dimethoxy-amphetamine derivatives by capillary electrophoresis with mass spectrometry detection from urine samples. AU - Nieddu,Maria, AU - Boatto,Gianpiero, AU - Dessì,Giuseppina, Y1 - 2007/02/24/ PY - 2006/10/26/received PY - 2006/12/14/revised PY - 2007/02/12/accepted PY - 2007/3/10/pubmed PY - 2007/8/2/medline PY - 2007/3/10/entrez SP - 578 EP - 81 JF - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences JO - J Chromatogr B Analyt Technol Biomed Life Sci VL - 852 IS - 1-2 N2 - The methylenedioxy-derivatives of amphetamine represent the largest group of designer drugs. The 4-methyl (DOM), -ethyl (DOET) and -propyl (DOPR) derivatives of 2,5-dimethoxy-amphetamine (2,5-DMA) were found to possess quite similar serotonin receptor affinities [R.A. Glennon, D.L. Doot, R. Young, Pharmacol. Biochem. Behav. 14 (1981) 287.]. This paper describes a method to screen for and quantify DOM, DOET and DOPR in urine samples, using capillary electrophoresis coupled to electrospray ionisation-mass spectrometry (CE-ESI-MS). Prior to CE-MS analysis, a simple solid-phase extraction (SPE) was used for sample cleanup. The method was validated according to international guidelines. Data for accuracy and precision were within required limits. Calibration curves were generated ranging from 10 to 1000 ng/mL and correlation coefficients always exceeded 0.996. SN - 1570-0232 UR - https://www.unboundmedicine.com/medline/citation/17347059/Determination_of_4_alkyl_25_dimethoxy_amphetamine_derivatives_by_capillary_electrophoresis_with_mass_spectrometry_detection_from_urine_samples_ DB - PRIME DP - Unbound Medicine ER -