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Chitotriosidase activity in the serum of patients with sarcoidosis and pulmonary tuberculosis.
Respiration. 2007; 74(5):548-52.R

Abstract

BACKGROUND

Human chitotriosidase is a chitinase selectively expressed by activated macrophages. An increase in chitotriosidase activity was previously described by us in the serum and bronchoalveolar lavage of sarcoidosis patients.

OBJECTIVE

The aim of the present study was to analyze serum chitotriosidase activity in a larger number of sarcoidosis patients to verify the reported increase with respect to controls and to compare serum chitotriosidase levels in patients with sarcoidosis and tuberculosis, two granulomatous disorders of different etiology.

METHODS

Chitotriosidase activity was measured in the serum of 96 sarcoidosis patients, 15 pulmonary tuberculosis patients and 30 healthy controls.

RESULTS

We found significantly higher serum chitotriosidase activity in sarcoidosis patients than controls (p < 0.01) and in sarcoidosis patients than tuberculosis patients (p < 0.01), confirming a striking elevation of chitotriosidase activity (>10 times greater than normal) in pulmonary sarcoidosis patients. This is the first time that chitotriosidase activity has been analyzed in the serum of patients with pulmonary tuberculosis; it was found to be significantly lower than in sarcoidosis patients and not significantly greater than in controls.

CONCLUSION

Although the mechanisms leading to the increase in chitotriosidase activity in sarcoidosis are still unknown, this enzyme may be specifically involved in the pathogenesis of the disease. Further studies with a greater number of patients are needed to confirm these results and to determine whether chitotriosidase could be a marker with diagnostic or prognostic value in sarcoidosis.

Authors+Show Affiliations

Department of Clinical Medicine and Immunology, Respiratory Diseases Section, University of Siena, Siena, Italy. bargagli2@unisi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17347558

Citation

Bargagli, Elena, et al. "Chitotriosidase Activity in the Serum of Patients With Sarcoidosis and Pulmonary Tuberculosis." Respiration; International Review of Thoracic Diseases, vol. 74, no. 5, 2007, pp. 548-52.
Bargagli E, Margollicci M, Nikiforakis N, et al. Chitotriosidase activity in the serum of patients with sarcoidosis and pulmonary tuberculosis. Respiration. 2007;74(5):548-52.
Bargagli, E., Margollicci, M., Nikiforakis, N., Luddi, A., Perrone, A., Grosso, S., & Rottoli, P. (2007). Chitotriosidase activity in the serum of patients with sarcoidosis and pulmonary tuberculosis. Respiration; International Review of Thoracic Diseases, 74(5), 548-52.
Bargagli E, et al. Chitotriosidase Activity in the Serum of Patients With Sarcoidosis and Pulmonary Tuberculosis. Respiration. 2007;74(5):548-52. PubMed PMID: 17347558.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chitotriosidase activity in the serum of patients with sarcoidosis and pulmonary tuberculosis. AU - Bargagli,Elena, AU - Margollicci,Maria, AU - Nikiforakis,Nikolaos, AU - Luddi,Alice, AU - Perrone,Anna, AU - Grosso,Salvatore, AU - Rottoli,Paola, Y1 - 2007/03/07/ PY - 2006/07/03/received PY - 2006/12/28/accepted PY - 2007/3/10/pubmed PY - 2007/10/24/medline PY - 2007/3/10/entrez SP - 548 EP - 52 JF - Respiration; international review of thoracic diseases JO - Respiration VL - 74 IS - 5 N2 - BACKGROUND: Human chitotriosidase is a chitinase selectively expressed by activated macrophages. An increase in chitotriosidase activity was previously described by us in the serum and bronchoalveolar lavage of sarcoidosis patients. OBJECTIVE: The aim of the present study was to analyze serum chitotriosidase activity in a larger number of sarcoidosis patients to verify the reported increase with respect to controls and to compare serum chitotriosidase levels in patients with sarcoidosis and tuberculosis, two granulomatous disorders of different etiology. METHODS: Chitotriosidase activity was measured in the serum of 96 sarcoidosis patients, 15 pulmonary tuberculosis patients and 30 healthy controls. RESULTS: We found significantly higher serum chitotriosidase activity in sarcoidosis patients than controls (p < 0.01) and in sarcoidosis patients than tuberculosis patients (p < 0.01), confirming a striking elevation of chitotriosidase activity (>10 times greater than normal) in pulmonary sarcoidosis patients. This is the first time that chitotriosidase activity has been analyzed in the serum of patients with pulmonary tuberculosis; it was found to be significantly lower than in sarcoidosis patients and not significantly greater than in controls. CONCLUSION: Although the mechanisms leading to the increase in chitotriosidase activity in sarcoidosis are still unknown, this enzyme may be specifically involved in the pathogenesis of the disease. Further studies with a greater number of patients are needed to confirm these results and to determine whether chitotriosidase could be a marker with diagnostic or prognostic value in sarcoidosis. SN - 0025-7931 UR - https://www.unboundmedicine.com/medline/citation/17347558/Chitotriosidase_activity_in_the_serum_of_patients_with_sarcoidosis_and_pulmonary_tuberculosis_ L2 - https://www.karger.com?DOI=10.1159/000100555 DB - PRIME DP - Unbound Medicine ER -