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Association between mild renal dysfunction and insulin resistance or metabolic syndrome in a random nondiabetic population sample.
Kidney Blood Press Res. 2007; 30(2):88-96.KB

Abstract

AIMS

The association of mild renal dysfunction (estimated glomerular filtration rate [eGFR] 60-89.9 ml/min/1.73 m(2)) with insulin resistance (IR) or metabolic syndrome (MS) needs be investigated in a population in which MS prevails.

METHODS

After excluding subjects with diabetes mellitus, 1,678 subjects from a representative cohort (median age 52 years) were studied cross-sectionally. eGFR was based on serum creatinine concentrations using the quadratic GFR equation and categorized by 90 and 60 ml/min/1.73 m(2) as limits. MS was identified using the modified criteria of the Adult Treatment Panel-III.

RESULTS

In men, whereas MS was not significantly associated with a reduced eGFR category when controlled for homeostatic model assessment (HOMA), HOMA adjusted for MS or for its components was significantly associated with the likelihood of a reduced eGFR. This likelihood was increased by 14% with a doubling of HOMA in men. Age was the dominant correlate of reduced eGFR in women, whereby an association with HOMA was not significant.

CONCLUSION

Mildly impaired kidney function is common in nondiabetic adults among whom MS prevails, and in men it is mainly associated with IR but not with central obesity and MS-related dyslipidemia. The quadratic GFR equation enables an acceptable estimation of GFR in a general population.

Links

Publisher Full Text

Authors+Show Affiliations

Onat A
Turkish Society of Cardiology, Istanbul University, Istanbul, Turkey. alt_onat@yahoo.com.tr
Hergenç G
No affiliation info available
Uyarel H
No affiliation info available
Ozhan H
No affiliation info available
Esen AM
No affiliation info available
Karabulut A
No affiliation info available
Albayrak S
No affiliation info available
Can G
No affiliation info available
Keleş I
No affiliation info available

MeSH

AdultC-Reactive ProteinCohort StudiesCreatinineCross-Sectional StudiesFemaleGlomerular Filtration RateHomeostasisHumansInsulin ResistanceKidneyKidney DiseasesLinear ModelsMaleMetabolic SyndromeMiddle AgedProspective StudiesRisk FactorsSex CharacteristicsTurkey

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17347575

Citation

Onat, Altan, et al. "Association Between Mild Renal Dysfunction and Insulin Resistance or Metabolic Syndrome in a Random Nondiabetic Population Sample." Kidney & Blood Pressure Research, vol. 30, no. 2, 2007, pp. 88-96.
Onat A, Hergenç G, Uyarel H, et al. Association between mild renal dysfunction and insulin resistance or metabolic syndrome in a random nondiabetic population sample. Kidney Blood Press Res. 2007;30(2):88-96.
Onat, A., Hergenç, G., Uyarel, H., Ozhan, H., Esen, A. M., Karabulut, A., Albayrak, S., Can, G., & Keleş, I. (2007). Association between mild renal dysfunction and insulin resistance or metabolic syndrome in a random nondiabetic population sample. Kidney & Blood Pressure Research, 30(2), 88-96.
Onat A, et al. Association Between Mild Renal Dysfunction and Insulin Resistance or Metabolic Syndrome in a Random Nondiabetic Population Sample. Kidney Blood Press Res. 2007;30(2):88-96. PubMed PMID: 17347575.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between mild renal dysfunction and insulin resistance or metabolic syndrome in a random nondiabetic population sample. AU - Onat,Altan, AU - Hergenç,Gulay, AU - Uyarel,Huseyin, AU - Ozhan,Hakan, AU - Esen,A Metin, AU - Karabulut,Ahmet, AU - Albayrak,Sinan, AU - Can,Gunay, AU - Keleş,Ibrahim, Y1 - 2007/03/07/ PY - 2006/08/10/received PY - 2007/01/22/accepted PY - 2007/3/10/pubmed PY - 2007/6/23/medline PY - 2007/3/10/entrez SP - 88 EP - 96 JF - Kidney & blood pressure research JO - Kidney Blood Press Res VL - 30 IS - 2 N2 - AIMS: The association of mild renal dysfunction (estimated glomerular filtration rate [eGFR] 60-89.9 ml/min/1.73 m(2)) with insulin resistance (IR) or metabolic syndrome (MS) needs be investigated in a population in which MS prevails. METHODS: After excluding subjects with diabetes mellitus, 1,678 subjects from a representative cohort (median age 52 years) were studied cross-sectionally. eGFR was based on serum creatinine concentrations using the quadratic GFR equation and categorized by 90 and 60 ml/min/1.73 m(2) as limits. MS was identified using the modified criteria of the Adult Treatment Panel-III. RESULTS: In men, whereas MS was not significantly associated with a reduced eGFR category when controlled for homeostatic model assessment (HOMA), HOMA adjusted for MS or for its components was significantly associated with the likelihood of a reduced eGFR. This likelihood was increased by 14% with a doubling of HOMA in men. Age was the dominant correlate of reduced eGFR in women, whereby an association with HOMA was not significant. CONCLUSION: Mildly impaired kidney function is common in nondiabetic adults among whom MS prevails, and in men it is mainly associated with IR but not with central obesity and MS-related dyslipidemia. The quadratic GFR equation enables an acceptable estimation of GFR in a general population. SN - 1420-4096 UR - https://www.unboundmedicine.com/medline/citation/17347575/Association_between_mild_renal_dysfunction_and_insulin_resistance_or_metabolic_syndrome_in_a_random_nondiabetic_population_sample_ L2 - https://www.karger.com?DOI=10.1159/000100487 DB - PRIME DP - Unbound Medicine ER -