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Bioavailability of a silybin-phosphatidylcholine complex in dogs.
J Vet Pharmacol Ther. 2007 Apr; 30(2):132-8.JV

Abstract

Liver dysfunction often is associated with an imbalance in the production and removal of free radicals derived from oxygen and nitrogen and has been managed clinically with antioxidant supplements, including silymarin extract derived from milk thistle. The potential for enhanced bioavailability of a phytosome complex containing phosphatidylcholine and silybin, the primary active flavonolignan in silymarin extract, was tested in dogs. A group of eight beagles (four males, four females) were dosed orally with a silybin-phosphatidylcholine complex (SPC) and a commercially available standardized silymarin extract containing equivalent levels of silybin. Dosing with the SPC resulted in Cmax, Tmax, and AUC0-24 h values (mean+/-SD) for total silybin of 1310+/-880 ng/mL, 2.87+/-2.23 h, and 11,200+/-6520 ng.h/mL, respectively; corresponding values for a standardized silymarin extract were 472+/-383 ng/mL, 4.75+/-2.82 h, and 3720+/-4970 ng.h/mL. A second, separate group of beagles were also dosed with the extract alone, yielding values of 449+/-402 ng/mL, 6.87+/-7.43 h, and 2520+/-2976 ng.h/mL. These data show that a phytosome complex of phosphatidylcholine and silybin markedly enhances bioavailability in dogs.

Authors+Show Affiliations

Veterinary Science Division, Nutramax Laboratories, Inc., Edgewood, MD 21040, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17348898

Citation

Filburn, C R., et al. "Bioavailability of a Silybin-phosphatidylcholine Complex in Dogs." Journal of Veterinary Pharmacology and Therapeutics, vol. 30, no. 2, 2007, pp. 132-8.
Filburn CR, Kettenacker R, Griffin DW. Bioavailability of a silybin-phosphatidylcholine complex in dogs. J Vet Pharmacol Ther. 2007;30(2):132-8.
Filburn, C. R., Kettenacker, R., & Griffin, D. W. (2007). Bioavailability of a silybin-phosphatidylcholine complex in dogs. Journal of Veterinary Pharmacology and Therapeutics, 30(2), 132-8.
Filburn CR, Kettenacker R, Griffin DW. Bioavailability of a Silybin-phosphatidylcholine Complex in Dogs. J Vet Pharmacol Ther. 2007;30(2):132-8. PubMed PMID: 17348898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioavailability of a silybin-phosphatidylcholine complex in dogs. AU - Filburn,C R, AU - Kettenacker,R, AU - Griffin,D W, PY - 2007/3/14/pubmed PY - 2007/4/25/medline PY - 2007/3/14/entrez SP - 132 EP - 8 JF - Journal of veterinary pharmacology and therapeutics JO - J. Vet. Pharmacol. Ther. VL - 30 IS - 2 N2 - Liver dysfunction often is associated with an imbalance in the production and removal of free radicals derived from oxygen and nitrogen and has been managed clinically with antioxidant supplements, including silymarin extract derived from milk thistle. The potential for enhanced bioavailability of a phytosome complex containing phosphatidylcholine and silybin, the primary active flavonolignan in silymarin extract, was tested in dogs. A group of eight beagles (four males, four females) were dosed orally with a silybin-phosphatidylcholine complex (SPC) and a commercially available standardized silymarin extract containing equivalent levels of silybin. Dosing with the SPC resulted in Cmax, Tmax, and AUC0-24 h values (mean+/-SD) for total silybin of 1310+/-880 ng/mL, 2.87+/-2.23 h, and 11,200+/-6520 ng.h/mL, respectively; corresponding values for a standardized silymarin extract were 472+/-383 ng/mL, 4.75+/-2.82 h, and 3720+/-4970 ng.h/mL. A second, separate group of beagles were also dosed with the extract alone, yielding values of 449+/-402 ng/mL, 6.87+/-7.43 h, and 2520+/-2976 ng.h/mL. These data show that a phytosome complex of phosphatidylcholine and silybin markedly enhances bioavailability in dogs. SN - 0140-7783 UR - https://www.unboundmedicine.com/medline/citation/17348898/Bioavailability_of_a_silybin_phosphatidylcholine_complex_in_dogs_ L2 - https://doi.org/10.1111/j.1365-2885.2007.00834.x DB - PRIME DP - Unbound Medicine ER -