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Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility.
Fertil Steril 2007; 88(6):1568-72FS

Abstract

OBJECTIVE

To investigate the response to controlled ovarian hyperstimulation and ART outcomes in women with advanced-stage endometriosis and previous surgeries at the Yale IVF program between 1996 and 2002.

DESIGN

Retrospective case control study.

SETTING

Academic medical center.

PATIENT(S)

The study group consisted of 68 women who previously undergone laparoscopic surgery for advanced-stage endometriosis. The control group included 106 women with tubal-factor infertility. The women with endometriosis underwent 133 IVF-ET cycles and the control group 208 cycles.

INTERVENTION(S)

Controlled ovarian hyperstimulation and IVF-ET.

MAIN OUTCOME MEASURE(S)

Response to gonadotropins, fertilization, cleavage, implantation, pregnancy, miscarriage, and live birth rates.

RESULT(S)

Lower peak E(2) levels, higher total gonadotropin requirements, lower oocyte yield, and higher cancellation rates were found in women with endometriosis compared with tubal-factor control subjects. However, no differences were found in fertilization, cleavage, implantation, pregnancy, miscarriage, and delivery rates between the endometriosis and tubal-factor groups.

CONCLUSION(S)

Women with advanced-stage endometriosis who have undergone previous surgery respond less well to gonadotropins than women with tubal-factor infertility. However, implantation, pregnancy, and delivery rates are similar, suggesting that embryo quality and uterine receptivity remains unaffected despite diminished ovarian reserve in women with endometriosis.

Authors+Show Affiliations

Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA. matakgr@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

17349642

Citation

Matalliotakis, Ioannis M., et al. "Women With Advanced-stage Endometriosis and Previous Surgery Respond Less Well to Gonadotropin Stimulation, but Have Similar IVF Implantation and Delivery Rates Compared With Women With Tubal Factor Infertility." Fertility and Sterility, vol. 88, no. 6, 2007, pp. 1568-72.
Matalliotakis IM, Cakmak H, Mahutte N, et al. Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertil Steril. 2007;88(6):1568-72.
Matalliotakis, I. M., Cakmak, H., Mahutte, N., Fragouli, Y., Arici, A., & Sakkas, D. (2007). Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. Fertility and Sterility, 88(6), pp. 1568-72.
Matalliotakis IM, et al. Women With Advanced-stage Endometriosis and Previous Surgery Respond Less Well to Gonadotropin Stimulation, but Have Similar IVF Implantation and Delivery Rates Compared With Women With Tubal Factor Infertility. Fertil Steril. 2007;88(6):1568-72. PubMed PMID: 17349642.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Women with advanced-stage endometriosis and previous surgery respond less well to gonadotropin stimulation, but have similar IVF implantation and delivery rates compared with women with tubal factor infertility. AU - Matalliotakis,Ioannis M, AU - Cakmak,Hakan, AU - Mahutte,Neal, AU - Fragouli,Yvoni, AU - Arici,Aydin, AU - Sakkas,Denny, Y1 - 2007/03/08/ PY - 2006/08/21/received PY - 2007/01/05/revised PY - 2007/01/05/accepted PY - 2007/3/14/pubmed PY - 2008/2/6/medline PY - 2007/3/14/entrez SP - 1568 EP - 72 JF - Fertility and sterility JO - Fertil. Steril. VL - 88 IS - 6 N2 - OBJECTIVE: To investigate the response to controlled ovarian hyperstimulation and ART outcomes in women with advanced-stage endometriosis and previous surgeries at the Yale IVF program between 1996 and 2002. DESIGN: Retrospective case control study. SETTING: Academic medical center. PATIENT(S): The study group consisted of 68 women who previously undergone laparoscopic surgery for advanced-stage endometriosis. The control group included 106 women with tubal-factor infertility. The women with endometriosis underwent 133 IVF-ET cycles and the control group 208 cycles. INTERVENTION(S): Controlled ovarian hyperstimulation and IVF-ET. MAIN OUTCOME MEASURE(S): Response to gonadotropins, fertilization, cleavage, implantation, pregnancy, miscarriage, and live birth rates. RESULT(S): Lower peak E(2) levels, higher total gonadotropin requirements, lower oocyte yield, and higher cancellation rates were found in women with endometriosis compared with tubal-factor control subjects. However, no differences were found in fertilization, cleavage, implantation, pregnancy, miscarriage, and delivery rates between the endometriosis and tubal-factor groups. CONCLUSION(S): Women with advanced-stage endometriosis who have undergone previous surgery respond less well to gonadotropins than women with tubal-factor infertility. However, implantation, pregnancy, and delivery rates are similar, suggesting that embryo quality and uterine receptivity remains unaffected despite diminished ovarian reserve in women with endometriosis. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/17349642/Women_with_advanced_stage_endometriosis_and_previous_surgery_respond_less_well_to_gonadotropin_stimulation_but_have_similar_IVF_implantation_and_delivery_rates_compared_with_women_with_tubal_factor_infertility_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(07)00171-9 DB - PRIME DP - Unbound Medicine ER -