TY - JOUR T1 - High performance liquid chromatographic determination of 3-methylflavone-8-carboxylic acid, the main active metabolite of flavoxate hydrochloride in human urine. AU - El-Gindy,Alaa, AU - Sallam,Shehab, AU - Abdel-Salam,Randa A, Y1 - 2007/02/06/ PY - 2006/08/01/received PY - 2007/01/28/revised PY - 2007/01/31/accepted PY - 2007/3/14/pubmed PY - 2007/6/23/medline PY - 2007/3/14/entrez SP - 274 EP - 8 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 44 IS - 1 N2 - High performance liquid chromatographic (HPLC) method was presented for the determination of 3-methylflavone-8-carboxylic acid as the main active metabolite of flavoxate hydrochloride (FX) in human urine. The proposed method was based on using CN column with mobile phase consisting of acetonitrile-12 mM ammonium acetate (40:60, v/v) and adjusted to apparent pH 4.0 with flow rate of 1.5 ml min(-1). Quantitation was achieved with UV detection at 220 nm. The proposed method was utilized to the determination of dissolution rate for tablets containing flavoxate hydrochloride. The urinary excretion pattern has been calculated using the proposed method. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/17349765/High_performance_liquid_chromatographic_determination_of_3_methylflavone_8_carboxylic_acid_the_main_active_metabolite_of_flavoxate_hydrochloride_in_human_urine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(07)00092-1 DB - PRIME DP - Unbound Medicine ER -