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Non-motor dysfunction in Parkinson's disease.
Parkinsonism Relat Disord. 2007 Aug; 13(6):323-32.PR

Abstract

In the field of neurology, Parkinson's disease (PD) is commonly perceived to be a disorder affecting only the (extrapyramidal) motor system, characteristically manifesting as bradykinesia, rigidity, tremor and postural instability. Although non-motor symptoms such as behavioural abnormalities, dysautonomia, sleep disturbances and sensory dysfunctions are also common and quite disabling manifestations of the disease, they are often not formally assessed and thus are frequently misdiagnosed and/or under diagnosed. For this reason, in this review we have concentrated on the pathophysiological and clinical basis of non-motor involvement such as olfactory dysfunction, depression, dementia, dysautonomia and sleep disorders in PD. The early recognition of these symptoms may well perhaps lead to an earlier diagnosis of PD, but in any case should lead to more prompt and effective treatment of the relatively unrecognized non-motor problems associated with PD.

Authors+Show Affiliations

Neurological University Clinic, Technische Universität Dresden, Fetscherstrasse 74, D-01307 Dresden, Germany. Ziemssen@web.deNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17349813

Citation

Ziemssen, Tjalf, and Heinz Reichmann. "Non-motor Dysfunction in Parkinson's Disease." Parkinsonism & Related Disorders, vol. 13, no. 6, 2007, pp. 323-32.
Ziemssen T, Reichmann H. Non-motor dysfunction in Parkinson's disease. Parkinsonism Relat Disord. 2007;13(6):323-32.
Ziemssen, T., & Reichmann, H. (2007). Non-motor dysfunction in Parkinson's disease. Parkinsonism & Related Disorders, 13(6), 323-32.
Ziemssen T, Reichmann H. Non-motor Dysfunction in Parkinson's Disease. Parkinsonism Relat Disord. 2007;13(6):323-32. PubMed PMID: 17349813.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Non-motor dysfunction in Parkinson's disease. AU - Ziemssen,Tjalf, AU - Reichmann,Heinz, Y1 - 2007/03/08/ PY - 2006/11/03/received PY - 2006/12/30/revised PY - 2006/12/30/accepted PY - 2007/3/14/pubmed PY - 2007/12/7/medline PY - 2007/3/14/entrez SP - 323 EP - 32 JF - Parkinsonism & related disorders JO - Parkinsonism Relat Disord VL - 13 IS - 6 N2 - In the field of neurology, Parkinson's disease (PD) is commonly perceived to be a disorder affecting only the (extrapyramidal) motor system, characteristically manifesting as bradykinesia, rigidity, tremor and postural instability. Although non-motor symptoms such as behavioural abnormalities, dysautonomia, sleep disturbances and sensory dysfunctions are also common and quite disabling manifestations of the disease, they are often not formally assessed and thus are frequently misdiagnosed and/or under diagnosed. For this reason, in this review we have concentrated on the pathophysiological and clinical basis of non-motor involvement such as olfactory dysfunction, depression, dementia, dysautonomia and sleep disorders in PD. The early recognition of these symptoms may well perhaps lead to an earlier diagnosis of PD, but in any case should lead to more prompt and effective treatment of the relatively unrecognized non-motor problems associated with PD. SN - 1353-8020 UR - https://www.unboundmedicine.com/medline/citation/17349813/Non_motor_dysfunction_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(07)00005-3 DB - PRIME DP - Unbound Medicine ER -