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Association of A1C with cardiovascular disease and metabolic syndrome in Asian Indians with normal glucose tolerance.
Diabetes Care. 2007 Jun; 30(6):1527-32.DC

Abstract

OBJECTIVE

This study examines the association of A1C with cardiovascular disease (CVD) risk factors, coronary artery disease (CAD), and metabolic syndrome in Asian Indians with normal glucose tolerance (NGT).

RESEARCH DESIGN AND METHODS

This cross-sectional study recruited subjects from phase III of the Chennai Urban Rural Epidemiology Study (CURES), an epidemiological study in a representative population of Chennai (formerly Madras) in South India, conducted between January 2003 and June 2004. Included were 1,644 subjects with NGT, i.e., fasting plasma glucose <100 mg/dl (5.6 mmol/l) and 2-h postload plasma glucose <140 mg/dl (7.8 mmol/l). A1C was measured using the Biorad Variant machine. Metabolic syndrome was defined based on modified Adult Treatment Panel III guidelines.

RESULTS

The mean +/- SD A1C value in the study cohort was 5.5 +/- 0.4%. A1C showed a significant association with BMI (beta = 0.017, P < 0.001), systolic (beta = 0.002, P = 0.028) and diastolic (beta = 0.202, P = 0.017) blood pressure, waist circumference (beta = 0.007, P < 0.001), serum cholesterol (beta = 0.002, P < 0.001), triglycerides (beta = 0.001, P < 0.001), LDL cholesterol (beta = 0.002, P < 0.001), fasting insulin (beta = 0.009, P < 0.001), and homeostasis model assessment of insulin resistance (beta = 0.047, P < 0.001) after adjusting for age and sex. Regression analysis showed that A1C had a strong association with metabolic syndrome that persisted after adjusting for age and sex (odds ratio [OR] 2.9 [95% CI 2.08-4.00]; P < 0.001). A1C also had a strong association with CAD (2.6 [1.23-5.63]; P = 0.01), but the significance was lost when adjusted for age and sex.

CONCLUSIONS

There is a strong association of A1C with prevalent CVD risk factors in Asian-Indian subjects with NGT.

Authors+Show Affiliations

Madras Diabetes Research Foundation & Dr. Mohan's Diabetes Specialities Centre, Gopalapuram, Chennai, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17351274

Citation

Dilley, James, et al. "Association of A1C With Cardiovascular Disease and Metabolic Syndrome in Asian Indians With Normal Glucose Tolerance." Diabetes Care, vol. 30, no. 6, 2007, pp. 1527-32.
Dilley J, Ganesan A, Deepa R, et al. Association of A1C with cardiovascular disease and metabolic syndrome in Asian Indians with normal glucose tolerance. Diabetes Care. 2007;30(6):1527-32.
Dilley, J., Ganesan, A., Deepa, R., Deepa, M., Sharada, G., Williams, O. D., & Mohan, V. (2007). Association of A1C with cardiovascular disease and metabolic syndrome in Asian Indians with normal glucose tolerance. Diabetes Care, 30(6), 1527-32.
Dilley J, et al. Association of A1C With Cardiovascular Disease and Metabolic Syndrome in Asian Indians With Normal Glucose Tolerance. Diabetes Care. 2007;30(6):1527-32. PubMed PMID: 17351274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of A1C with cardiovascular disease and metabolic syndrome in Asian Indians with normal glucose tolerance. AU - Dilley,James, AU - Ganesan,Anbazhagan, AU - Deepa,Raj, AU - Deepa,Mohan, AU - Sharada,Gopalakrishnan, AU - Williams,O Dale, AU - Mohan,Viswanathan, Y1 - 2007/03/10/ PY - 2007/3/14/pubmed PY - 2007/6/15/medline PY - 2007/3/14/entrez SP - 1527 EP - 32 JF - Diabetes care JO - Diabetes Care VL - 30 IS - 6 N2 - OBJECTIVE: This study examines the association of A1C with cardiovascular disease (CVD) risk factors, coronary artery disease (CAD), and metabolic syndrome in Asian Indians with normal glucose tolerance (NGT). RESEARCH DESIGN AND METHODS: This cross-sectional study recruited subjects from phase III of the Chennai Urban Rural Epidemiology Study (CURES), an epidemiological study in a representative population of Chennai (formerly Madras) in South India, conducted between January 2003 and June 2004. Included were 1,644 subjects with NGT, i.e., fasting plasma glucose <100 mg/dl (5.6 mmol/l) and 2-h postload plasma glucose <140 mg/dl (7.8 mmol/l). A1C was measured using the Biorad Variant machine. Metabolic syndrome was defined based on modified Adult Treatment Panel III guidelines. RESULTS: The mean +/- SD A1C value in the study cohort was 5.5 +/- 0.4%. A1C showed a significant association with BMI (beta = 0.017, P < 0.001), systolic (beta = 0.002, P = 0.028) and diastolic (beta = 0.202, P = 0.017) blood pressure, waist circumference (beta = 0.007, P < 0.001), serum cholesterol (beta = 0.002, P < 0.001), triglycerides (beta = 0.001, P < 0.001), LDL cholesterol (beta = 0.002, P < 0.001), fasting insulin (beta = 0.009, P < 0.001), and homeostasis model assessment of insulin resistance (beta = 0.047, P < 0.001) after adjusting for age and sex. Regression analysis showed that A1C had a strong association with metabolic syndrome that persisted after adjusting for age and sex (odds ratio [OR] 2.9 [95% CI 2.08-4.00]; P < 0.001). A1C also had a strong association with CAD (2.6 [1.23-5.63]; P = 0.01), but the significance was lost when adjusted for age and sex. CONCLUSIONS: There is a strong association of A1C with prevalent CVD risk factors in Asian-Indian subjects with NGT. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/17351274/Association_of_A1C_with_cardiovascular_disease_and_metabolic_syndrome_in_Asian_Indians_with_normal_glucose_tolerance_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&amp;pmid=17351274 DB - PRIME DP - Unbound Medicine ER -