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High serum IGFBP-2 is predictive of increased bone turnover in aging men and women.
J Bone Miner Res. 2007 Jun; 22(6):799-807.JB

Abstract

Elevated serum IGFBP-2 is associated with lower BMD in men and women. It is unknown whether IGFBP-2 serves as a negative regulator of bone metabolism by decreasing bone formation or increasing bone resorption. Studying an age-stratified community-based sample of 344 men and 276 women, IGFBP-2 was the strongest predictor of increased bone resorption among the IGF/IGFBPs studied.

INTRODUCTION

Serum insulin-like growth factor binding protein-2 (IGFBP-2), which increases with age, is a predictor of low BMD among aging men and women. However, it is unknown whether IGFBP-2 negatively influences bone metabolism by decreasing bone formation or increasing bone resorption. Few have examined the relation between the insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) with bone turnover markers.

MATERIALS AND METHODS

In an age-stratified, random sample of the community, we examined the association between serum IGF-I, IGF-II, IGFBP-1, -2, and -3, and bone turnover markers before and after adjustment for potential confounders (age, body mass index, bioavailable estradiol and testosterone, and sex hormone binding globulin). Analyses were stratified by sex and menopausal status.

RESULTS

We studied 344 men (age range, 23-90 yr) and 276 women (age range, 21-93 yr; 166 postmenopausal) not on oral contraceptives or hormone replacement. Among the IGF/IGFBPs assessed, IGFBP-2 was the strongest and most consistent predictor of bone turnover in men and women. After adjustment for potential confounders, IGFBP-2 was positively associated with osteocalcin (OC) and urine and serum N-teleopeptide (NTX) in men (r = 0.20, 0.26, and 0.23, respectively; p < 0.001), serum C-telopeptide (CTX) in premenopausal women (r = 0.28; p < 0.01), and OC, urine NTX, and serum CTX in postmenopausal women (r = 0.24, 0.33, and 0.19, respectively; p < 0.05).

CONCLUSIONS

Higher serum IGFBP-2, which is predictive of lower BMD, is associated with increased markers of bone resorption, independent of age, body mass, and sex hormones. The association between IGFBP-2 and markers of bone formation may reflect coupling with increased bone resorption, which is not adequate to maintain BMD.

Authors+Show Affiliations

Division of Rheumatology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA. amin.shreyasee@mayo.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17352648

Citation

Amin, Shreyasee, et al. "High Serum IGFBP-2 Is Predictive of Increased Bone Turnover in Aging Men and Women." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 22, no. 6, 2007, pp. 799-807.
Amin S, Riggs BL, Melton LJ, et al. High serum IGFBP-2 is predictive of increased bone turnover in aging men and women. J Bone Miner Res. 2007;22(6):799-807.
Amin, S., Riggs, B. L., Melton, L. J., Achenbach, S. J., Atkinson, E. J., & Khosla, S. (2007). High serum IGFBP-2 is predictive of increased bone turnover in aging men and women. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 22(6), 799-807.
Amin S, et al. High Serum IGFBP-2 Is Predictive of Increased Bone Turnover in Aging Men and Women. J Bone Miner Res. 2007;22(6):799-807. PubMed PMID: 17352648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High serum IGFBP-2 is predictive of increased bone turnover in aging men and women. AU - Amin,Shreyasee, AU - Riggs,B Lawrence, AU - Melton,L Joseph,3rd AU - Achenbach,Sara J, AU - Atkinson,Elizabeth J, AU - Khosla,Sundeep, PY - 2007/3/14/pubmed PY - 2007/8/30/medline PY - 2007/3/14/entrez SP - 799 EP - 807 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J. Bone Miner. Res. VL - 22 IS - 6 N2 - UNLABELLED: Elevated serum IGFBP-2 is associated with lower BMD in men and women. It is unknown whether IGFBP-2 serves as a negative regulator of bone metabolism by decreasing bone formation or increasing bone resorption. Studying an age-stratified community-based sample of 344 men and 276 women, IGFBP-2 was the strongest predictor of increased bone resorption among the IGF/IGFBPs studied. INTRODUCTION: Serum insulin-like growth factor binding protein-2 (IGFBP-2), which increases with age, is a predictor of low BMD among aging men and women. However, it is unknown whether IGFBP-2 negatively influences bone metabolism by decreasing bone formation or increasing bone resorption. Few have examined the relation between the insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) with bone turnover markers. MATERIALS AND METHODS: In an age-stratified, random sample of the community, we examined the association between serum IGF-I, IGF-II, IGFBP-1, -2, and -3, and bone turnover markers before and after adjustment for potential confounders (age, body mass index, bioavailable estradiol and testosterone, and sex hormone binding globulin). Analyses were stratified by sex and menopausal status. RESULTS: We studied 344 men (age range, 23-90 yr) and 276 women (age range, 21-93 yr; 166 postmenopausal) not on oral contraceptives or hormone replacement. Among the IGF/IGFBPs assessed, IGFBP-2 was the strongest and most consistent predictor of bone turnover in men and women. After adjustment for potential confounders, IGFBP-2 was positively associated with osteocalcin (OC) and urine and serum N-teleopeptide (NTX) in men (r = 0.20, 0.26, and 0.23, respectively; p < 0.001), serum C-telopeptide (CTX) in premenopausal women (r = 0.28; p < 0.01), and OC, urine NTX, and serum CTX in postmenopausal women (r = 0.24, 0.33, and 0.19, respectively; p < 0.05). CONCLUSIONS: Higher serum IGFBP-2, which is predictive of lower BMD, is associated with increased markers of bone resorption, independent of age, body mass, and sex hormones. The association between IGFBP-2 and markers of bone formation may reflect coupling with increased bone resorption, which is not adequate to maintain BMD. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/17352648/High_serum_IGFBP_2_is_predictive_of_increased_bone_turnover_in_aging_men_and_women_ L2 - https://doi.org/10.1359/jbmr.070306 DB - PRIME DP - Unbound Medicine ER -