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Interactions between breast-feeding, specific parental atopy, and sex on development of asthma and atopy.
J Allergy Clin Immunol. 2007 Jun; 119(6):1359-66.JA

Abstract

BACKGROUND

The influence of breast-feeding on the risk of developing atopy and asthma remains controversial.

OBJECTIVE

To examine asthma and atopy outcomes by sex, reported specific parental history of atopy, and breast-feeding.

METHODS

In a birth cohort, we examined childhood asthma and atopy (positive skin prick tests) by sex and breast-feeding in relation to maternal and paternal atopy. Interactions were explored in logistic regression models.

RESULTS

For boys, breast-feeding (odds ratio [OR], 1.63; 95% CI, 0.93-2.87; P = .09) and maternal atopy (OR, 1.95; 95% CI, 0.93-4.08; P = .08) were each associated with atopy at age 13 years. Breast-feeding increased the risk for atopy among boys with paternal atopy (OR, 7.39; 95% CI, 2.21-24.66) compared with non-breast-fed boys with paternal atopy, but did not significantly further increase risk among subjects with maternal atopy. For girls, breast-feeding (OR, 0.74; 95% CI, 0.41-1.31) and maternal and paternal atopy were not independent risk factors for atopy at age 13 years. However, breast-feeding increased the risk for atopy in girls with maternal atopy (OR, 3.13; 95% CI, 1.20-8.14) compared with non-breast-fed girls with maternal atopy. There was no such effect among subjects with paternal atopy. Results for the outcome of asthma followed a similar pattern.

CONCLUSION

The influence of breast-feeding on development of atopy and asthma differs by sex and by maternal and paternal atopy, and is most significant among subjects at lower baseline risk.

CLINICAL IMPLICATIONS

Analyses of environmental risk factors for asthma and atopy should be stratified by specific parental atopy and sex.

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Authors+Show Affiliations

Mandhane PJ
Firestone Institute for Respiratory Health, St Joseph's Healthcare, and Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Greene JM
No affiliation info available
Sears MR
No affiliation info available

MeSH

AdolescentAdultAsthmaBreast FeedingBronchial HyperreactivityChildFemaleHumansHypersensitivity, ImmediateLogistic ModelsMaleNew ZealandParentsProspective StudiesRisk FactorsSex Factors

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17353035

Citation

Mandhane, Piush J., et al. "Interactions Between Breast-feeding, Specific Parental Atopy, and Sex On Development of Asthma and Atopy." The Journal of Allergy and Clinical Immunology, vol. 119, no. 6, 2007, pp. 1359-66.
Mandhane PJ, Greene JM, Sears MR. Interactions between breast-feeding, specific parental atopy, and sex on development of asthma and atopy. J Allergy Clin Immunol. 2007;119(6):1359-66.
Mandhane, P. J., Greene, J. M., & Sears, M. R. (2007). Interactions between breast-feeding, specific parental atopy, and sex on development of asthma and atopy. The Journal of Allergy and Clinical Immunology, 119(6), 1359-66.
Mandhane PJ, Greene JM, Sears MR. Interactions Between Breast-feeding, Specific Parental Atopy, and Sex On Development of Asthma and Atopy. J Allergy Clin Immunol. 2007;119(6):1359-66. PubMed PMID: 17353035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interactions between breast-feeding, specific parental atopy, and sex on development of asthma and atopy. AU - Mandhane,Piush J, AU - Greene,Justina M, AU - Sears,Malcolm R, Y1 - 2007/03/13/ PY - 2006/05/08/received PY - 2007/01/15/revised PY - 2007/01/25/accepted PY - 2007/3/14/pubmed PY - 2007/7/28/medline PY - 2007/3/14/entrez SP - 1359 EP - 66 JF - The Journal of allergy and clinical immunology JO - J Allergy Clin Immunol VL - 119 IS - 6 N2 - BACKGROUND: The influence of breast-feeding on the risk of developing atopy and asthma remains controversial. OBJECTIVE: To examine asthma and atopy outcomes by sex, reported specific parental history of atopy, and breast-feeding. METHODS: In a birth cohort, we examined childhood asthma and atopy (positive skin prick tests) by sex and breast-feeding in relation to maternal and paternal atopy. Interactions were explored in logistic regression models. RESULTS: For boys, breast-feeding (odds ratio [OR], 1.63; 95% CI, 0.93-2.87; P = .09) and maternal atopy (OR, 1.95; 95% CI, 0.93-4.08; P = .08) were each associated with atopy at age 13 years. Breast-feeding increased the risk for atopy among boys with paternal atopy (OR, 7.39; 95% CI, 2.21-24.66) compared with non-breast-fed boys with paternal atopy, but did not significantly further increase risk among subjects with maternal atopy. For girls, breast-feeding (OR, 0.74; 95% CI, 0.41-1.31) and maternal and paternal atopy were not independent risk factors for atopy at age 13 years. However, breast-feeding increased the risk for atopy in girls with maternal atopy (OR, 3.13; 95% CI, 1.20-8.14) compared with non-breast-fed girls with maternal atopy. There was no such effect among subjects with paternal atopy. Results for the outcome of asthma followed a similar pattern. CONCLUSION: The influence of breast-feeding on development of atopy and asthma differs by sex and by maternal and paternal atopy, and is most significant among subjects at lower baseline risk. CLINICAL IMPLICATIONS: Analyses of environmental risk factors for asthma and atopy should be stratified by specific parental atopy and sex. SN - 0091-6749 UR - https://www.unboundmedicine.com/medline/citation/17353035/Interactions_between_breast_feeding_specific_parental_atopy_and_sex_on_development_of_asthma_and_atopy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-6749(07)00353-3 DB - PRIME DP - Unbound Medicine ER -