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Treatment of acute otitis media with probiotics in otitis-prone children-a double-blind, placebo-controlled randomised study.
Clin Nutr. 2007 Jun; 26(3):314-21.CN

Abstract

BACKGROUND & AIMS

To examine whether probiotics would reduce the occurrence or duration of acute otitis media (AOM), or the nasopharyngeal carriage of otitis pathogens in otitis-prone children.

METHODS

During this double-blind, placebo-controlled, randomised, 24-week intervention, 309 otitis-prone children (10 months-6 years) consumed either one probiotic capsule (Lactobacillus rhamnosus GG and LC705, Bifidobacterium breve 99 and Propionibacterium freudenreichii JS) (n=155) or placebo (n=154) daily. Clinical examinations were carried out and nasopharyngeal samples taken three times. Parents recorded the symptoms of upper respiratory infection (URI) in a diary.

RESULTS

Probiotic treatment did not reduce the occurrence (probiotic vs. placebo: 72% vs. 65%, OR=1.48, 95% CI 0.87-2.52, p=n.s.) or the recurrence (three) of AOM episodes (18% vs. 17%, OR=1.04, 95% CI 0.55-1.96, p=n.s.). The median duration of AOM episodes was 5.6 (IQR 3.5-9.4) vs. 6.0 (IQR 4.0-10.5) days, respectively (p= n.s.). There was a tendency showing a reduction in the occurrence of recurrent (4 to 6) respiratory infections in the probiotic group (OR for 4 URIs: 0.56, 95%CI 0.31-0.99, p=0.046; OR for 6 URIs: 0.59, 95% CI 0.34 to 1.03, p=n.s.). Probiotics did not affect the carriage of Streptococcus pneumoniae or Haemophilus influenzae, but increased the prevalence of Moraxella catarrhalis (OR=1.79, 95% CI 1.06-3.00, p=0.028).

CONCLUSIONS

Probiotics did not prevent the occurrence of AOM or the nasopharyngeal carriage of otitis pathogens in otitis-prone children. A tendency showing a reduction in recurrent respiratory infections must be confirmed in further studies.

Authors+Show Affiliations

Valio Ltd, R&D, FIN-00039 Helsinki, Finland. katja.hatakka@valio.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17353072

Citation

Hatakka, Katja, et al. "Treatment of Acute Otitis Media With Probiotics in Otitis-prone Children-a Double-blind, Placebo-controlled Randomised Study." Clinical Nutrition (Edinburgh, Scotland), vol. 26, no. 3, 2007, pp. 314-21.
Hatakka K, Blomgren K, Pohjavuori S, et al. Treatment of acute otitis media with probiotics in otitis-prone children-a double-blind, placebo-controlled randomised study. Clin Nutr. 2007;26(3):314-21.
Hatakka, K., Blomgren, K., Pohjavuori, S., Kaijalainen, T., Poussa, T., Leinonen, M., Korpela, R., & Pitkäranta, A. (2007). Treatment of acute otitis media with probiotics in otitis-prone children-a double-blind, placebo-controlled randomised study. Clinical Nutrition (Edinburgh, Scotland), 26(3), 314-21.
Hatakka K, et al. Treatment of Acute Otitis Media With Probiotics in Otitis-prone Children-a Double-blind, Placebo-controlled Randomised Study. Clin Nutr. 2007;26(3):314-21. PubMed PMID: 17353072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of acute otitis media with probiotics in otitis-prone children-a double-blind, placebo-controlled randomised study. AU - Hatakka,Katja, AU - Blomgren,Karin, AU - Pohjavuori,Sara, AU - Kaijalainen,Tarja, AU - Poussa,Tuija, AU - Leinonen,Maija, AU - Korpela,Riitta, AU - Pitkäranta,Anne, Y1 - 2007/03/13/ PY - 2006/05/31/received PY - 2007/01/10/revised PY - 2007/01/19/accepted PY - 2007/3/14/pubmed PY - 2007/9/5/medline PY - 2007/3/14/entrez SP - 314 EP - 21 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 26 IS - 3 N2 - BACKGROUND & AIMS: To examine whether probiotics would reduce the occurrence or duration of acute otitis media (AOM), or the nasopharyngeal carriage of otitis pathogens in otitis-prone children. METHODS: During this double-blind, placebo-controlled, randomised, 24-week intervention, 309 otitis-prone children (10 months-6 years) consumed either one probiotic capsule (Lactobacillus rhamnosus GG and LC705, Bifidobacterium breve 99 and Propionibacterium freudenreichii JS) (n=155) or placebo (n=154) daily. Clinical examinations were carried out and nasopharyngeal samples taken three times. Parents recorded the symptoms of upper respiratory infection (URI) in a diary. RESULTS: Probiotic treatment did not reduce the occurrence (probiotic vs. placebo: 72% vs. 65%, OR=1.48, 95% CI 0.87-2.52, p=n.s.) or the recurrence (three) of AOM episodes (18% vs. 17%, OR=1.04, 95% CI 0.55-1.96, p=n.s.). The median duration of AOM episodes was 5.6 (IQR 3.5-9.4) vs. 6.0 (IQR 4.0-10.5) days, respectively (p= n.s.). There was a tendency showing a reduction in the occurrence of recurrent (4 to 6) respiratory infections in the probiotic group (OR for 4 URIs: 0.56, 95%CI 0.31-0.99, p=0.046; OR for 6 URIs: 0.59, 95% CI 0.34 to 1.03, p=n.s.). Probiotics did not affect the carriage of Streptococcus pneumoniae or Haemophilus influenzae, but increased the prevalence of Moraxella catarrhalis (OR=1.79, 95% CI 1.06-3.00, p=0.028). CONCLUSIONS: Probiotics did not prevent the occurrence of AOM or the nasopharyngeal carriage of otitis pathogens in otitis-prone children. A tendency showing a reduction in recurrent respiratory infections must be confirmed in further studies. SN - 0261-5614 UR - https://www.unboundmedicine.com/medline/citation/17353072/Treatment_of_acute_otitis_media_with_probiotics_in_otitis_prone_children_a_double_blind_placebo_controlled_randomised_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(07)00028-3 DB - PRIME DP - Unbound Medicine ER -