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High-sensitivity C-reactive protein, other markers of inflammation, and the incidence of macular degeneration in women.
Arch Ophthalmol 2007; 125(3):300-5AO

Abstract

OBJECTIVE

To investigate whether high-sensitivity C-reactive protein (hsCRP) and other biomarkers of inflammation predict age-related macular degeneration (AMD).

METHODS

We measured hsCRP, soluble intercellular adhesion molecule-1 (sICAM-1), and fibrinogen levels in baseline plasma samples from 27 687 participants with a mean age of 54.6 years and initially free of AMD in the Women's Health Study. We prospectively ascertained 150 cases of AMD with vision loss of 20/30 or worse in the affected eye by self-report confirmed with review of medical records during 275 852 person-years of follow-up (mean = 10 years) and used proportional hazards models to examine the relationship between these biomarkers and AMD.

RESULTS

After adjustment for multiple risk factors, the hazard ratio (HR) (95% confidence interval [CI]) of AMD, contrasting the highest vs lowest quintile of hsCRP, was 3.09 (1.39-6.88) (P trend = .02). In similar models, the HR (95% CI) for sICAM-1 was 1.87 (0.97-3.58) (P trend = .07). The relationship between fibrinogen and AMD was J-shaped, with an HR (95% CI) of 2.01 (1.07-3.75) for women in the highest fifth vs second fifth.

CONCLUSION

Elevated circulating levels of hsCRP, sICAM-1, and fibrinogen precede the development of visually significant AMD in women, providing further support for the hypothesis that inflammation may play a role in AMD.

Authors+Show Affiliations

Division of Preventive Medicine, 900 Commonwealth Ave E, Boston, MA 02215, USA. dschaumberg@rics.bwh.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17353399

Citation

Schaumberg, Debra A., et al. "High-sensitivity C-reactive Protein, Other Markers of Inflammation, and the Incidence of Macular Degeneration in Women." Archives of Ophthalmology (Chicago, Ill. : 1960), vol. 125, no. 3, 2007, pp. 300-5.
Schaumberg DA, Christen WG, Buring JE, et al. High-sensitivity C-reactive protein, other markers of inflammation, and the incidence of macular degeneration in women. Arch Ophthalmol. 2007;125(3):300-5.
Schaumberg, D. A., Christen, W. G., Buring, J. E., Glynn, R. J., Rifai, N., & Ridker, P. M. (2007). High-sensitivity C-reactive protein, other markers of inflammation, and the incidence of macular degeneration in women. Archives of Ophthalmology (Chicago, Ill. : 1960), 125(3), pp. 300-5.
Schaumberg DA, et al. High-sensitivity C-reactive Protein, Other Markers of Inflammation, and the Incidence of Macular Degeneration in Women. Arch Ophthalmol. 2007;125(3):300-5. PubMed PMID: 17353399.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High-sensitivity C-reactive protein, other markers of inflammation, and the incidence of macular degeneration in women. AU - Schaumberg,Debra A, AU - Christen,William G, AU - Buring,Julie E, AU - Glynn,Robert J, AU - Rifai,Nader, AU - Ridker,Paul M, PY - 2007/3/14/pubmed PY - 2007/3/23/medline PY - 2007/3/14/entrez SP - 300 EP - 5 JF - Archives of ophthalmology (Chicago, Ill. : 1960) JO - Arch. Ophthalmol. VL - 125 IS - 3 N2 - OBJECTIVE: To investigate whether high-sensitivity C-reactive protein (hsCRP) and other biomarkers of inflammation predict age-related macular degeneration (AMD). METHODS: We measured hsCRP, soluble intercellular adhesion molecule-1 (sICAM-1), and fibrinogen levels in baseline plasma samples from 27 687 participants with a mean age of 54.6 years and initially free of AMD in the Women's Health Study. We prospectively ascertained 150 cases of AMD with vision loss of 20/30 or worse in the affected eye by self-report confirmed with review of medical records during 275 852 person-years of follow-up (mean = 10 years) and used proportional hazards models to examine the relationship between these biomarkers and AMD. RESULTS: After adjustment for multiple risk factors, the hazard ratio (HR) (95% confidence interval [CI]) of AMD, contrasting the highest vs lowest quintile of hsCRP, was 3.09 (1.39-6.88) (P trend = .02). In similar models, the HR (95% CI) for sICAM-1 was 1.87 (0.97-3.58) (P trend = .07). The relationship between fibrinogen and AMD was J-shaped, with an HR (95% CI) of 2.01 (1.07-3.75) for women in the highest fifth vs second fifth. CONCLUSION: Elevated circulating levels of hsCRP, sICAM-1, and fibrinogen precede the development of visually significant AMD in women, providing further support for the hypothesis that inflammation may play a role in AMD. SN - 0003-9950 UR - https://www.unboundmedicine.com/medline/citation/17353399/High_sensitivity_C_reactive_protein_other_markers_of_inflammation_and_the_incidence_of_macular_degeneration_in_women_ L2 - https://jamanetwork.com/journals/jamaophthalmology/fullarticle/10.1001/archopht.125.3.300 DB - PRIME DP - Unbound Medicine ER -