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Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese.
Int J Cancer 2007; 121(2):377-85IJ

Abstract

Dietary intake of fish rich in n-3 highly unsaturated fatty acids (HUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been proposed to decrease cancer risk. In contrast to results from laboratory studies, however, protective effects for breast cancer have proved equivocal in epidemiological studies. In the present case-control study, we examined associations between breast cancer risk and fatty acid compositions in erythrocyte membranes as biomarkers for those intakes. Dietary information and blood samples were collected from 103 incident breast cancer cases and 309 non-cancer controls (matched by age and season) and erythrocyte fatty acids were measured using accelerated solvent extraction and gas-liquid chromatography. Dietary intake of n-3 HUFAs demonstrated a negative association with risk (the highest to the lowest tertile, odds ratio (OR), 0.51; 95% confidence interval (CI), 0.27-0.98; p(trend)<0.05), but there was no association with those of saturated fatty acids (SFAs) and meat. Moreover, risk was inversely associated with erythrocyte compositions of EPA (OR, 0.27; 95% CI, 0.14-0.53; p(trend)<0.0001), DHA (OR, 0.06; 95% CI, 0.02-0.16; p(trend)<0.0001) and n-3 HUFAs (OR, 0.11; 95% CI, 0.05-0.24; p(trend)<0.0001), and positively with that of SFAs (OR, 12.29; 95% CI, 4.94-30.57; p(trend)<0.0001) and the ratio of SFAs/n-3 HUFAs (OR, 14.65; 95% CI, 5.67-37.82; p(trend)<0.0001). In conclusion, we showed that erythrocyte compositions of specific fatty acids derived from fish intake, as biomarkers, are associated with lower risk of breast cancer, but further studies are needed to investigate mechanisms linked to the etiology.

Authors+Show Affiliations

Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-8681, Japan. kkuriki@aichi-cc.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17354239

Citation

Kuriki, Kiyonori, et al. "Breast Cancer Risk and Erythrocyte Compositions of N-3 Highly Unsaturated Fatty Acids in Japanese." International Journal of Cancer, vol. 121, no. 2, 2007, pp. 377-85.
Kuriki K, Hirose K, Wakai K, et al. Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese. Int J Cancer. 2007;121(2):377-85.
Kuriki, K., Hirose, K., Wakai, K., Matsuo, K., Ito, H., Suzuki, T., ... Tajima, K. (2007). Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese. International Journal of Cancer, 121(2), pp. 377-85.
Kuriki K, et al. Breast Cancer Risk and Erythrocyte Compositions of N-3 Highly Unsaturated Fatty Acids in Japanese. Int J Cancer. 2007 Jul 15;121(2):377-85. PubMed PMID: 17354239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breast cancer risk and erythrocyte compositions of n-3 highly unsaturated fatty acids in Japanese. AU - Kuriki,Kiyonori, AU - Hirose,Kaoru, AU - Wakai,Kenji, AU - Matsuo,Keitaro, AU - Ito,Hidemi, AU - Suzuki,Takeshi, AU - Hiraki,Akio, AU - Saito,Toshiko, AU - Iwata,Hiroji, AU - Tatematsu,Masae, AU - Tajima,Kazuo, PY - 2007/3/14/pubmed PY - 2007/8/7/medline PY - 2007/3/14/entrez SP - 377 EP - 85 JF - International journal of cancer JO - Int. J. Cancer VL - 121 IS - 2 N2 - Dietary intake of fish rich in n-3 highly unsaturated fatty acids (HUFAs), such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been proposed to decrease cancer risk. In contrast to results from laboratory studies, however, protective effects for breast cancer have proved equivocal in epidemiological studies. In the present case-control study, we examined associations between breast cancer risk and fatty acid compositions in erythrocyte membranes as biomarkers for those intakes. Dietary information and blood samples were collected from 103 incident breast cancer cases and 309 non-cancer controls (matched by age and season) and erythrocyte fatty acids were measured using accelerated solvent extraction and gas-liquid chromatography. Dietary intake of n-3 HUFAs demonstrated a negative association with risk (the highest to the lowest tertile, odds ratio (OR), 0.51; 95% confidence interval (CI), 0.27-0.98; p(trend)<0.05), but there was no association with those of saturated fatty acids (SFAs) and meat. Moreover, risk was inversely associated with erythrocyte compositions of EPA (OR, 0.27; 95% CI, 0.14-0.53; p(trend)<0.0001), DHA (OR, 0.06; 95% CI, 0.02-0.16; p(trend)<0.0001) and n-3 HUFAs (OR, 0.11; 95% CI, 0.05-0.24; p(trend)<0.0001), and positively with that of SFAs (OR, 12.29; 95% CI, 4.94-30.57; p(trend)<0.0001) and the ratio of SFAs/n-3 HUFAs (OR, 14.65; 95% CI, 5.67-37.82; p(trend)<0.0001). In conclusion, we showed that erythrocyte compositions of specific fatty acids derived from fish intake, as biomarkers, are associated with lower risk of breast cancer, but further studies are needed to investigate mechanisms linked to the etiology. SN - 0020-7136 UR - https://www.unboundmedicine.com/medline/citation/17354239/Breast_cancer_risk_and_erythrocyte_compositions_of_n_3_highly_unsaturated_fatty_acids_in_Japanese_ L2 - https://doi.org/10.1002/ijc.22682 DB - PRIME DP - Unbound Medicine ER -