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Comparative study of neurological soft signs in schizophrenia with onset in childhood, adolescence and adulthood.
Acta Psychiatr Scand 2007; 115(4):295-303AP

Abstract

OBJECTIVE

To compare neurological soft signs (NSS) in patients of schizophrenia with onset in childhood (COS), adolescence (AdOS) and adulthood (AOS).

METHOD

Assessment of NSS in 15 patients of COS and 20 patients each of AdOS and AOS was made using condensed neuropsychiatric examination for NSS.

RESULTS

NSS were significantly more frequent in COS (100%) and AdOS (90%) when compared with AOS (55%) patients. COS patients showed significantly higher scores on temporal and frontal lobe NSS, of which differences between the three groups in temporal lobe NSS disappeared on ancova. Parietal lobe dependent NSS were seen in a few COS patients. The NSS were more in those with lesser IQ, lower education and higher Positive and Negative Syndrome Scale scores.

CONCLUSION

Findings indicate that earlier onset types may be more strongly associated with a generalized disruption of brain function. Non-suppression of primitive reflexes with cortical maturation in COS point towards disordered neurodevelopment. Preponderance of fronto-temporal and a relative lack of parietal lobe NSS point towards differential lobar involvement. Neurodevelopmental abnormalities leading to NSS also lead to lower IQ and lower educational level.

Authors+Show Affiliations

Postgraduate Institute of Medical Education and Research, Chandigarh, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17355520

Citation

Biswas, P, et al. "Comparative Study of Neurological Soft Signs in Schizophrenia With Onset in Childhood, Adolescence and Adulthood." Acta Psychiatrica Scandinavica, vol. 115, no. 4, 2007, pp. 295-303.
Biswas P, Malhotra S, Malhotra A, et al. Comparative study of neurological soft signs in schizophrenia with onset in childhood, adolescence and adulthood. Acta Psychiatr Scand. 2007;115(4):295-303.
Biswas, P., Malhotra, S., Malhotra, A., & Gupta, N. (2007). Comparative study of neurological soft signs in schizophrenia with onset in childhood, adolescence and adulthood. Acta Psychiatrica Scandinavica, 115(4), pp. 295-303.
Biswas P, et al. Comparative Study of Neurological Soft Signs in Schizophrenia With Onset in Childhood, Adolescence and Adulthood. Acta Psychiatr Scand. 2007;115(4):295-303. PubMed PMID: 17355520.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative study of neurological soft signs in schizophrenia with onset in childhood, adolescence and adulthood. AU - Biswas,P, AU - Malhotra,S, AU - Malhotra,A, AU - Gupta,N, PY - 2007/3/16/pubmed PY - 2007/8/2/medline PY - 2007/3/16/entrez SP - 295 EP - 303 JF - Acta psychiatrica Scandinavica JO - Acta Psychiatr Scand VL - 115 IS - 4 N2 - OBJECTIVE: To compare neurological soft signs (NSS) in patients of schizophrenia with onset in childhood (COS), adolescence (AdOS) and adulthood (AOS). METHOD: Assessment of NSS in 15 patients of COS and 20 patients each of AdOS and AOS was made using condensed neuropsychiatric examination for NSS. RESULTS: NSS were significantly more frequent in COS (100%) and AdOS (90%) when compared with AOS (55%) patients. COS patients showed significantly higher scores on temporal and frontal lobe NSS, of which differences between the three groups in temporal lobe NSS disappeared on ancova. Parietal lobe dependent NSS were seen in a few COS patients. The NSS were more in those with lesser IQ, lower education and higher Positive and Negative Syndrome Scale scores. CONCLUSION: Findings indicate that earlier onset types may be more strongly associated with a generalized disruption of brain function. Non-suppression of primitive reflexes with cortical maturation in COS point towards disordered neurodevelopment. Preponderance of fronto-temporal and a relative lack of parietal lobe NSS point towards differential lobar involvement. Neurodevelopmental abnormalities leading to NSS also lead to lower IQ and lower educational level. SN - 0001-690X UR - https://www.unboundmedicine.com/medline/citation/17355520/Comparative_study_of_neurological_soft_signs_in_schizophrenia_with_onset_in_childhood_adolescence_and_adulthood_ L2 - https://doi.org/10.1111/j.1600-0447.2006.00901.x DB - PRIME DP - Unbound Medicine ER -