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Preclinical dementia: an Italian multicentre study on amnestic mild cognitive impairment.
Dement Geriatr Cogn Disord. 2007; 23(5):289-300.DG

Abstract

BACKGROUND

Different rates and cognitive predictors of conversion to dementia have been reported in subjects with different kinds of mild cognitive impairment (MCI).

METHODS

A prospective, 24-month follow-up study, involving 269 subjects who strictly fulfilled criteria for the amnestic MCI.

RESULTS

Conversion rate to dementia was 21.4% per year. Seventy-nine out of the 83 individuals who developed dementia were affected by probable Alzheimer's disease (AD). Among others, at the 24-month follow-up 24.1% were still affected by amnestic MCI, 13.3% had changed their neuropsychological profile of impairment and 17.2% were cognitively normalised. Compared to subjects who did not convert to AD, those who did convert showed poorer immediate and delayed recall and recognition of verbal and visual material at baseline as well as reduced executive abilities. A combination of age, Clinical Dementia Rating boxes and scores on delayed recall and recognition of verbal and visual material accurately identified 86% of the subjects who developed AD.

CONCLUSIONS

Elderly subjects affected by an isolated memory disorder have a high probability of developing AD. The ability of verbal and visual measures to predict incipient dementia of memory impairment may be increased by the simultaneous assessment of individual features, such as age or rate of functional impairment.

Authors+Show Affiliations

Foundation IRCCS Santa Lucia, Rome, Italy. r.perri@hsantalucia.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

17356272

Citation

Perri, R, et al. "Preclinical Dementia: an Italian Multicentre Study On Amnestic Mild Cognitive Impairment." Dementia and Geriatric Cognitive Disorders, vol. 23, no. 5, 2007, pp. 289-300.
Perri R, Serra L, Carlesimo GA, et al. Preclinical dementia: an Italian multicentre study on amnestic mild cognitive impairment. Dement Geriatr Cogn Disord. 2007;23(5):289-300.
Perri, R., Serra, L., Carlesimo, G. A., & Caltagirone, C. (2007). Preclinical dementia: an Italian multicentre study on amnestic mild cognitive impairment. Dementia and Geriatric Cognitive Disorders, 23(5), 289-300.
Perri R, et al. Preclinical Dementia: an Italian Multicentre Study On Amnestic Mild Cognitive Impairment. Dement Geriatr Cogn Disord. 2007;23(5):289-300. PubMed PMID: 17356272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preclinical dementia: an Italian multicentre study on amnestic mild cognitive impairment. AU - Perri,R, AU - Serra,L, AU - Carlesimo,G A, AU - Caltagirone,C, AU - ,, Y1 - 2007/03/13/ PY - 2006/07/21/accepted PY - 2007/3/16/pubmed PY - 2007/6/21/medline PY - 2007/3/16/entrez SP - 289 EP - 300 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 23 IS - 5 N2 - BACKGROUND: Different rates and cognitive predictors of conversion to dementia have been reported in subjects with different kinds of mild cognitive impairment (MCI). METHODS: A prospective, 24-month follow-up study, involving 269 subjects who strictly fulfilled criteria for the amnestic MCI. RESULTS: Conversion rate to dementia was 21.4% per year. Seventy-nine out of the 83 individuals who developed dementia were affected by probable Alzheimer's disease (AD). Among others, at the 24-month follow-up 24.1% were still affected by amnestic MCI, 13.3% had changed their neuropsychological profile of impairment and 17.2% were cognitively normalised. Compared to subjects who did not convert to AD, those who did convert showed poorer immediate and delayed recall and recognition of verbal and visual material at baseline as well as reduced executive abilities. A combination of age, Clinical Dementia Rating boxes and scores on delayed recall and recognition of verbal and visual material accurately identified 86% of the subjects who developed AD. CONCLUSIONS: Elderly subjects affected by an isolated memory disorder have a high probability of developing AD. The ability of verbal and visual measures to predict incipient dementia of memory impairment may be increased by the simultaneous assessment of individual features, such as age or rate of functional impairment. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/17356272/Preclinical_dementia:_an_Italian_multicentre_study_on_amnestic_mild_cognitive_impairment_ L2 - https://www.karger.com?DOI=10.1159/000100871 DB - PRIME DP - Unbound Medicine ER -