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The Semantic Object Retrieval Test (SORT) in amnestic mild cognitive impairment.
Cogn Behav Neurol 2007; 20(1):62-7CB

Abstract

BACKGROUND

Between 10% and 15% of patients with the amnestic variety of Mild Cognitive Impairment (MCI) convert to Alzheimer disease (AD) per year.

OBJECTIVE

Characterize cognitive markers that may herald conversion from MCI to AD and directly assess semantic memory in patients meeting criteria for amnestic MCI.

DESIGN

Thirty-five amnestic MCI patients and 121 healthy aging controls enrolled at an Alzheimer Disease Center received a battery of standard neuropsychologic tests, and the Semantic Object Retrieval Test (SORT), a test that we have developed for the assessment of semantic memory and subsequent name production, and that has been shown to be able to differentiate between normals and patients with AD.

RESULTS

On the basis of normative data from the SORT, the MCI subjects could be divided into 2 groups: 10 patients (29%) with a significant semantic impairment (SI+) and 25 without a semantic memory deficit (SI-). There was a significant correlation between all SORT variables and performance on the Boston Naming Test. In this MCI population, significantly impaired SORT performance was associated with a relative decrease in performance on tests of frontal lobe functions, although disruption of thalamic-related processes cannot be excluded as an etiology for semantic memory impairment.

CONCLUSIONS

The SORT is a specific test of semantic memory, and is a sensitive measure of semantic memory deficits in patients who otherwise meet criteria for amnestic MCI. Using this specific assessment tool, a significant number of MCI patients were found to have semantic memory deficits. As these patients may be early in the course of possible progression toward dementia, the SORT or other tests of semantic memory may provide important diagnostic or prognostic information in patients with MCI.

Authors+Show Affiliations

Department of Radiology, Division of Neuroradiology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Pub Type(s)

Evaluation Studies
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17356346

Citation

Kraut, Michael A., et al. "The Semantic Object Retrieval Test (SORT) in Amnestic Mild Cognitive Impairment." Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology, vol. 20, no. 1, 2007, pp. 62-7.
Kraut MA, Cherry B, Pitcock JA, et al. The Semantic Object Retrieval Test (SORT) in amnestic mild cognitive impairment. Cogn Behav Neurol. 2007;20(1):62-7.
Kraut, M. A., Cherry, B., Pitcock, J. A., Anand, R., Li, J., Vestal, L., ... Hart, J. (2007). The Semantic Object Retrieval Test (SORT) in amnestic mild cognitive impairment. Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology, 20(1), pp. 62-7.
Kraut MA, et al. The Semantic Object Retrieval Test (SORT) in Amnestic Mild Cognitive Impairment. Cogn Behav Neurol. 2007;20(1):62-7. PubMed PMID: 17356346.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Semantic Object Retrieval Test (SORT) in amnestic mild cognitive impairment. AU - Kraut,Michael A, AU - Cherry,Barbara, AU - Pitcock,Jeffery A, AU - Anand,Raksha, AU - Li,Juan, AU - Vestal,Lindsey, AU - Henderson,Victor W, AU - Hart,John,Jr PY - 2007/3/16/pubmed PY - 2007/5/11/medline PY - 2007/3/16/entrez SP - 62 EP - 7 JF - Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology JO - Cogn Behav Neurol VL - 20 IS - 1 N2 - BACKGROUND: Between 10% and 15% of patients with the amnestic variety of Mild Cognitive Impairment (MCI) convert to Alzheimer disease (AD) per year. OBJECTIVE: Characterize cognitive markers that may herald conversion from MCI to AD and directly assess semantic memory in patients meeting criteria for amnestic MCI. DESIGN: Thirty-five amnestic MCI patients and 121 healthy aging controls enrolled at an Alzheimer Disease Center received a battery of standard neuropsychologic tests, and the Semantic Object Retrieval Test (SORT), a test that we have developed for the assessment of semantic memory and subsequent name production, and that has been shown to be able to differentiate between normals and patients with AD. RESULTS: On the basis of normative data from the SORT, the MCI subjects could be divided into 2 groups: 10 patients (29%) with a significant semantic impairment (SI+) and 25 without a semantic memory deficit (SI-). There was a significant correlation between all SORT variables and performance on the Boston Naming Test. In this MCI population, significantly impaired SORT performance was associated with a relative decrease in performance on tests of frontal lobe functions, although disruption of thalamic-related processes cannot be excluded as an etiology for semantic memory impairment. CONCLUSIONS: The SORT is a specific test of semantic memory, and is a sensitive measure of semantic memory deficits in patients who otherwise meet criteria for amnestic MCI. Using this specific assessment tool, a significant number of MCI patients were found to have semantic memory deficits. As these patients may be early in the course of possible progression toward dementia, the SORT or other tests of semantic memory may provide important diagnostic or prognostic information in patients with MCI. SN - 1543-3633 UR - https://www.unboundmedicine.com/medline/citation/17356346/The_Semantic_Object_Retrieval_Test__SORT__in_amnestic_mild_cognitive_impairment_ L2 - http://Insights.ovid.com/pubmed?pmid=17356346 DB - PRIME DP - Unbound Medicine ER -