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Birth size, adult body composition and muscle strength in later life.
Int J Obes (Lond) 2007; 31(9):1392-9IJ

Abstract

OBJECTIVE

Low birth weight has been linked to lower lean body mass and abdominal obesity later in life, whereas high birth weight has been suggested to predict later obesity as indicated by high body mass index (BMI). We examined how birth weight was related to adult body size, body composition and grip strength.

DESIGN/SUBJECTS

Cross-sectional study on 928 men and 1075 women born in 1934-1944, with measurements at birth recorded.

MEASUREMENTS

Height, weight, waist and hip circumference and isometric grip strength were measured. Lean and fat body mass were estimated by bioelectrical impedance with an eight-polar tactile electrode system.

RESULTS

A 1 kg increase in birth weight corresponded in men to a 4.1 kg (95% CI: 3.1, 5.1) and in women to a 2.9 kg (2.1, 3.6) increase in adult lean mass. This association remained significant after adjustment for age, adult body size, physical activity, smoking status, social class and maternal size. Grip strength was positively related to birth weight through its association with lean mass. The positive association of birth weight with adult BMI was explained by its association with lean mass. Low birth weight was related to higher body fat percentage only after adjustment for adult BMI. Abdominal obesity was not predicted by low birth weight.

CONCLUSIONS

Low birth weight is associated with lower lean mass in adult life and thus contributes to the risk of relative sarcopenia and the related functional inability at the other end of the lifespan. At a given level of adult BMI, low birth weight predicts higher body fat percentage.

Authors+Show Affiliations

Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland. hilkka.yliharsila@ktl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17356523

Citation

Ylihärsilä, H, et al. "Birth Size, Adult Body Composition and Muscle Strength in Later Life." International Journal of Obesity (2005), vol. 31, no. 9, 2007, pp. 1392-9.
Ylihärsilä H, Kajantie E, Osmond C, et al. Birth size, adult body composition and muscle strength in later life. Int J Obes (Lond). 2007;31(9):1392-9.
Ylihärsilä, H., Kajantie, E., Osmond, C., Forsén, T., Barker, D. J., & Eriksson, J. G. (2007). Birth size, adult body composition and muscle strength in later life. International Journal of Obesity (2005), 31(9), pp. 1392-9.
Ylihärsilä H, et al. Birth Size, Adult Body Composition and Muscle Strength in Later Life. Int J Obes (Lond). 2007;31(9):1392-9. PubMed PMID: 17356523.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Birth size, adult body composition and muscle strength in later life. AU - Ylihärsilä,H, AU - Kajantie,E, AU - Osmond,C, AU - Forsén,T, AU - Barker,D J P, AU - Eriksson,J G, Y1 - 2007/03/13/ PY - 2007/3/16/pubmed PY - 2007/12/6/medline PY - 2007/3/16/entrez SP - 1392 EP - 9 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 31 IS - 9 N2 - OBJECTIVE: Low birth weight has been linked to lower lean body mass and abdominal obesity later in life, whereas high birth weight has been suggested to predict later obesity as indicated by high body mass index (BMI). We examined how birth weight was related to adult body size, body composition and grip strength. DESIGN/SUBJECTS: Cross-sectional study on 928 men and 1075 women born in 1934-1944, with measurements at birth recorded. MEASUREMENTS: Height, weight, waist and hip circumference and isometric grip strength were measured. Lean and fat body mass were estimated by bioelectrical impedance with an eight-polar tactile electrode system. RESULTS: A 1 kg increase in birth weight corresponded in men to a 4.1 kg (95% CI: 3.1, 5.1) and in women to a 2.9 kg (2.1, 3.6) increase in adult lean mass. This association remained significant after adjustment for age, adult body size, physical activity, smoking status, social class and maternal size. Grip strength was positively related to birth weight through its association with lean mass. The positive association of birth weight with adult BMI was explained by its association with lean mass. Low birth weight was related to higher body fat percentage only after adjustment for adult BMI. Abdominal obesity was not predicted by low birth weight. CONCLUSIONS: Low birth weight is associated with lower lean mass in adult life and thus contributes to the risk of relative sarcopenia and the related functional inability at the other end of the lifespan. At a given level of adult BMI, low birth weight predicts higher body fat percentage. SN - 0307-0565 UR - https://www.unboundmedicine.com/medline/citation/17356523/Birth_size_adult_body_composition_and_muscle_strength_in_later_life_ L2 - http://dx.doi.org/10.1038/sj.ijo.0803612 DB - PRIME DP - Unbound Medicine ER -