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Plasma magnesium and calcium levels in children with epilepsy in lagos.
Niger Postgrad Med J. 2007 Mar; 14(1):26-9.NP

Abstract

BACKGROUND

Magnesium and calcium have been found to have increasing roles in the patho-physiology of epilepsy. Hypomagnesaemia and hypocalcaemia cause hyper-exitability of neurons and have been associated strongly with seizures in adults and children.

OBJECTIVES

To determine if hypomagnesaemia or hypocalcaemia is present in Nigerian children with epilepsy and to determine the relationship between serum magnesium and calcium levels and frequency and control of epilepsy.

DESIGN

A prospective case control study at the Lagos University Teaching Hospital.

PATIENTS AND METHODS

45 children with epilepsy and 45 controls were recruited from the paediatric neurology unit of the Lagos University Teaching Hospital. Serum magnesium and calcium were measured by spectrophotometric methods.

RESULTS

Serum magnesium and calcium was significantly lower in the patients compared to the controls; Magnesium - 0.98 (0.0005) Vs 1.2 (0.04) mmol/L, p< 0.0001 and Calcium - 2.29 (0.04) Vs 2.3 (0.02) mmol/L, p<0.05 respectively. No significant differences were noted in the plasma phosphorus and albumin concentrations.

CONCLUSION

Magnesium and calcium levels are lower in the epileptic children compared to the controls during the seizure-free periods. More studies are needed to evaluate these electrolytes during seizures and the effect of the different anticonvulsant drugs on these electrolytes.

Authors+Show Affiliations

Department of Clinical Pathology,College of Medicine, University of Lagos/ Lagos University Teaching Hospital, Idi-Araba, Lagos.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17356585

Citation

Oladipo, O O., et al. "Plasma Magnesium and Calcium Levels in Children With Epilepsy in Lagos." The Nigerian Postgraduate Medical Journal, vol. 14, no. 1, 2007, pp. 26-9.
Oladipo OO, Lesi FE, Ezeaka VC. Plasma magnesium and calcium levels in children with epilepsy in lagos. Niger Postgrad Med J. 2007;14(1):26-9.
Oladipo, O. O., Lesi, F. E., & Ezeaka, V. C. (2007). Plasma magnesium and calcium levels in children with epilepsy in lagos. The Nigerian Postgraduate Medical Journal, 14(1), 26-9.
Oladipo OO, Lesi FE, Ezeaka VC. Plasma Magnesium and Calcium Levels in Children With Epilepsy in Lagos. Niger Postgrad Med J. 2007;14(1):26-9. PubMed PMID: 17356585.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma magnesium and calcium levels in children with epilepsy in lagos. AU - Oladipo,O O, AU - Lesi,F E A, AU - Ezeaka,V C, PY - 2007/3/16/pubmed PY - 2016/4/24/medline PY - 2007/3/16/entrez SP - 26 EP - 9 JF - The Nigerian postgraduate medical journal JO - Niger Postgrad Med J VL - 14 IS - 1 N2 - BACKGROUND: Magnesium and calcium have been found to have increasing roles in the patho-physiology of epilepsy. Hypomagnesaemia and hypocalcaemia cause hyper-exitability of neurons and have been associated strongly with seizures in adults and children. OBJECTIVES: To determine if hypomagnesaemia or hypocalcaemia is present in Nigerian children with epilepsy and to determine the relationship between serum magnesium and calcium levels and frequency and control of epilepsy. DESIGN: A prospective case control study at the Lagos University Teaching Hospital. PATIENTS AND METHODS: 45 children with epilepsy and 45 controls were recruited from the paediatric neurology unit of the Lagos University Teaching Hospital. Serum magnesium and calcium were measured by spectrophotometric methods. RESULTS: Serum magnesium and calcium was significantly lower in the patients compared to the controls; Magnesium - 0.98 (0.0005) Vs 1.2 (0.04) mmol/L, p< 0.0001 and Calcium - 2.29 (0.04) Vs 2.3 (0.02) mmol/L, p<0.05 respectively. No significant differences were noted in the plasma phosphorus and albumin concentrations. CONCLUSION: Magnesium and calcium levels are lower in the epileptic children compared to the controls during the seizure-free periods. More studies are needed to evaluate these electrolytes during seizures and the effect of the different anticonvulsant drugs on these electrolytes. SN - 1117-1936 UR - https://www.unboundmedicine.com/medline/citation/17356585/Plasma_magnesium_and_calcium_levels_in_children_with_epilepsy_in_lagos_ L2 - http://www.diseaseinfosearch.org/result/2593 DB - PRIME DP - Unbound Medicine ER -
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