Tags

Type your tag names separated by a space and hit enter

Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency.
J Infect Dis. 2007 Apr 15; 195(8):1184-8.JI

Abstract

Human immunodeficiency virus type 1 can occasionally be detected as a cryptic or latent infection in seronegative, asymptomatic patients. To develop an animal model of host latency, cats were mucosally challenged with 10(2)-10(6) feline immunodeficiency virus (FIV)-infected T cells. Although high-dose exposure (10(4)-10(6) T cells) resulted in progressive infection, no evidence of infection was seen in 5 of 6 cats exposed to 10(2) or 10(3) T cells. However, after ex vivo CD8(+) T cell depletion and phorbol myristate acetate treatment, FIV could be reactivated in tissues from 4 cats. Thus, latent tissue viral reservoirs can be induced by low-dose cell-associated mucosal challenge, providing a model to dissect the mechanisms that control reservoir establishment.

Authors+Show Affiliations

Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA. assogba.1@osu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

17357056

Citation

Assogba, Barnabe Dossou, et al. "Mucosal Administration of Low-dose Cell-associated Feline Immunodeficiency Virus Promotes Viral Latency." The Journal of Infectious Diseases, vol. 195, no. 8, 2007, pp. 1184-8.
Assogba BD, Leavell S, Porter K, et al. Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency. J Infect Dis. 2007;195(8):1184-8.
Assogba, B. D., Leavell, S., Porter, K., & Burkhard, M. J. (2007). Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency. The Journal of Infectious Diseases, 195(8), 1184-8.
Assogba BD, et al. Mucosal Administration of Low-dose Cell-associated Feline Immunodeficiency Virus Promotes Viral Latency. J Infect Dis. 2007 Apr 15;195(8):1184-8. PubMed PMID: 17357056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mucosal administration of low-dose cell-associated feline immunodeficiency virus promotes viral latency. AU - Assogba,Barnabe Dossou, AU - Leavell,Sarah, AU - Porter,Kyle, AU - Burkhard,Mary Jo, Y1 - 2007/03/02/ PY - 2006/08/23/received PY - 2006/11/22/accepted PY - 2007/3/16/pubmed PY - 2007/5/16/medline PY - 2007/3/16/entrez SP - 1184 EP - 8 JF - The Journal of infectious diseases JO - J Infect Dis VL - 195 IS - 8 N2 - Human immunodeficiency virus type 1 can occasionally be detected as a cryptic or latent infection in seronegative, asymptomatic patients. To develop an animal model of host latency, cats were mucosally challenged with 10(2)-10(6) feline immunodeficiency virus (FIV)-infected T cells. Although high-dose exposure (10(4)-10(6) T cells) resulted in progressive infection, no evidence of infection was seen in 5 of 6 cats exposed to 10(2) or 10(3) T cells. However, after ex vivo CD8(+) T cell depletion and phorbol myristate acetate treatment, FIV could be reactivated in tissues from 4 cats. Thus, latent tissue viral reservoirs can be induced by low-dose cell-associated mucosal challenge, providing a model to dissect the mechanisms that control reservoir establishment. SN - 0022-1899 UR - https://www.unboundmedicine.com/medline/citation/17357056/Mucosal_administration_of_low_dose_cell_associated_feline_immunodeficiency_virus_promotes_viral_latency_ L2 - https://academic.oup.com/jid/article-lookup/doi/10.1086/512861 DB - PRIME DP - Unbound Medicine ER -