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Role of scratch-induced cutaneous prostaglandin D production on atopic-like scratching behaviour in mice.
Exp Dermatol. 2007 Apr; 16(4):331-9.ED

Abstract

NC/Nga mice are known to develop scratching dermatitis akin to atopic dermatitis, under conventional (Conv), but not under the specific-pathogen-free (SPF) condition. In this study, we examined the effects of mechanical-scratching on the spontaneous scratching counts (sign of itching), in relation to the cutaneous prostaglandin D2 (PGD2) levels in NC/Nga or BALB/c mice. Mechanical-scratching increased the cutaneous barrier damage and PGD2 levels in both strain mice under the SPF condition. By 4 weeks of cohabitation with the skin-lesioned NC/Nga mice, both the increase in the spontaneous scratching and development of dermatitis score were higher in the Conv-NC/Nga than in the Conv-BALB/c mice. At this time-point, the cutaneous PGD2 level induced by mechanical-scratching was significantly lower in the Conv-NC/Nga when compared with that in the SPF-NC/Nga mice, and that in the Conv-BALB/c was almost equal to that in the SPF-BALB/c mice. With mechanical scratches, the cohabitation-induced scratching was suppressed in the Conv-BALB/c, but not in the Conv-NC/Nga mice. These results suggest that the scratch-induced cutaneous PGD2 inhibits scratching and the subsequent development of dermatitis in BALB/c, while the impaired scratch-induced cutaneous PGD2 production in the NC/Nga mice resulted in no suppression of scratching, and aggravated the dermatitis.

Authors+Show Affiliations

Medicinal Pharmacology Laboratory, Taisho Pharmaceutical Co., Ltd, Saitama, Japan. a.takaoka@po.rd.taisho.co.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17359340

Citation

Takaoka, Akiko, et al. "Role of Scratch-induced Cutaneous Prostaglandin D Production On Atopic-like Scratching Behaviour in Mice." Experimental Dermatology, vol. 16, no. 4, 2007, pp. 331-9.
Takaoka A, Arai I, Sugimoto M, et al. Role of scratch-induced cutaneous prostaglandin D production on atopic-like scratching behaviour in mice. Exp Dermatol. 2007;16(4):331-9.
Takaoka, A., Arai, I., Sugimoto, M., Futaki, N., Sakurai, T., Honma, Y., & Nakaike, S. (2007). Role of scratch-induced cutaneous prostaglandin D production on atopic-like scratching behaviour in mice. Experimental Dermatology, 16(4), 331-9.
Takaoka A, et al. Role of Scratch-induced Cutaneous Prostaglandin D Production On Atopic-like Scratching Behaviour in Mice. Exp Dermatol. 2007;16(4):331-9. PubMed PMID: 17359340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of scratch-induced cutaneous prostaglandin D production on atopic-like scratching behaviour in mice. AU - Takaoka,Akiko, AU - Arai,Iwao, AU - Sugimoto,Masanori, AU - Futaki,Nobuko, AU - Sakurai,Takanobu, AU - Honma,Yusuke, AU - Nakaike,Shiro, PY - 2007/3/16/pubmed PY - 2007/6/27/medline PY - 2007/3/16/entrez SP - 331 EP - 9 JF - Experimental dermatology JO - Exp Dermatol VL - 16 IS - 4 N2 - NC/Nga mice are known to develop scratching dermatitis akin to atopic dermatitis, under conventional (Conv), but not under the specific-pathogen-free (SPF) condition. In this study, we examined the effects of mechanical-scratching on the spontaneous scratching counts (sign of itching), in relation to the cutaneous prostaglandin D2 (PGD2) levels in NC/Nga or BALB/c mice. Mechanical-scratching increased the cutaneous barrier damage and PGD2 levels in both strain mice under the SPF condition. By 4 weeks of cohabitation with the skin-lesioned NC/Nga mice, both the increase in the spontaneous scratching and development of dermatitis score were higher in the Conv-NC/Nga than in the Conv-BALB/c mice. At this time-point, the cutaneous PGD2 level induced by mechanical-scratching was significantly lower in the Conv-NC/Nga when compared with that in the SPF-NC/Nga mice, and that in the Conv-BALB/c was almost equal to that in the SPF-BALB/c mice. With mechanical scratches, the cohabitation-induced scratching was suppressed in the Conv-BALB/c, but not in the Conv-NC/Nga mice. These results suggest that the scratch-induced cutaneous PGD2 inhibits scratching and the subsequent development of dermatitis in BALB/c, while the impaired scratch-induced cutaneous PGD2 production in the NC/Nga mice resulted in no suppression of scratching, and aggravated the dermatitis. SN - 0906-6705 UR - https://www.unboundmedicine.com/medline/citation/17359340/Role_of_scratch_induced_cutaneous_prostaglandin_D_production_on_atopic_like_scratching_behaviour_in_mice_ L2 - https://doi.org/10.1111/j.1600-0625.2006.00540.x DB - PRIME DP - Unbound Medicine ER -