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Vascular endothelial growth factor is associated with blood brain barrier dysfunction in eosinophilic meningitis caused by Angiostrongylus cantonensis infection.
Am J Trop Med Hyg. 2007 Mar; 76(3):592-5.AJ

Abstract

Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema. To assess the role of vascular endothelial growth factor in eosinophilic meningitis, vascular endothelial growth factor was measured in the cerebrospinal fluid (CSF) and blood of 9 patients with eosinophilic meningitis in a cohort study. VEGFCSF was detected in 8 (90%) of 9 eosinophilic meningitis patients (range, 45-2190 pg/mL) at presentation. The mean VEGFCSF at presentation, 1 week, and 2 weeks after admission was 568 pg/mL, 751 pg/mL, and 1031 pg/mL, respectively. There was an association between VEGFCSF, CSF protein, white cell count, and eosinophil counts. The VEGFSERUM fluctuated during the 6-month follow-up period. These results indicate that vascular endothelial growth factor may be associated with blood-brain barrier disruption in patients with eosinophilic meningitis.

Authors+Show Affiliations

Section of Infectious Diseases, Department of Medicine, Kaohsiung Veterans General Hospital, Kaohsiung City, and National Yang-Ming University, Taipei, Taiwan, Republic of China. hctsai1011@yahoo.com.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17360889

Citation

Tsai, Hung-Chin, et al. "Vascular Endothelial Growth Factor Is Associated With Blood Brain Barrier Dysfunction in Eosinophilic Meningitis Caused By Angiostrongylus Cantonensis Infection." The American Journal of Tropical Medicine and Hygiene, vol. 76, no. 3, 2007, pp. 592-5.
Tsai HC, Liu YC, Lee SS, et al. Vascular endothelial growth factor is associated with blood brain barrier dysfunction in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. Am J Trop Med Hyg. 2007;76(3):592-5.
Tsai, H. C., Liu, Y. C., Lee, S. S., Chen, E. R., & Yen, C. M. (2007). Vascular endothelial growth factor is associated with blood brain barrier dysfunction in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. The American Journal of Tropical Medicine and Hygiene, 76(3), 592-5.
Tsai HC, et al. Vascular Endothelial Growth Factor Is Associated With Blood Brain Barrier Dysfunction in Eosinophilic Meningitis Caused By Angiostrongylus Cantonensis Infection. Am J Trop Med Hyg. 2007;76(3):592-5. PubMed PMID: 17360889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular endothelial growth factor is associated with blood brain barrier dysfunction in eosinophilic meningitis caused by Angiostrongylus cantonensis infection. AU - Tsai,Hung-Chin, AU - Liu,Yung-Ching, AU - Lee,Susan Shin-Jung, AU - Chen,Eng-Rin, AU - Yen,Chuan-Min, PY - 2007/3/16/pubmed PY - 2007/4/18/medline PY - 2007/3/16/entrez SP - 592 EP - 5 JF - The American journal of tropical medicine and hygiene JO - Am J Trop Med Hyg VL - 76 IS - 3 N2 - Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor and a mediator of brain edema. To assess the role of vascular endothelial growth factor in eosinophilic meningitis, vascular endothelial growth factor was measured in the cerebrospinal fluid (CSF) and blood of 9 patients with eosinophilic meningitis in a cohort study. VEGFCSF was detected in 8 (90%) of 9 eosinophilic meningitis patients (range, 45-2190 pg/mL) at presentation. The mean VEGFCSF at presentation, 1 week, and 2 weeks after admission was 568 pg/mL, 751 pg/mL, and 1031 pg/mL, respectively. There was an association between VEGFCSF, CSF protein, white cell count, and eosinophil counts. The VEGFSERUM fluctuated during the 6-month follow-up period. These results indicate that vascular endothelial growth factor may be associated with blood-brain barrier disruption in patients with eosinophilic meningitis. SN - 0002-9637 UR - https://www.unboundmedicine.com/medline/citation/17360889/Vascular_endothelial_growth_factor_is_associated_with_blood_brain_barrier_dysfunction_in_eosinophilic_meningitis_caused_by_Angiostrongylus_cantonensis_infection_ L2 - https://medlineplus.gov/meningitis.html DB - PRIME DP - Unbound Medicine ER -