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Progressive impairment of erythrocyte deformability as indicator of microangiopathy in type 2 diabetes mellitus.
Clin Hemorheol Microcirc. 2007; 36(3):253-61.CH

Abstract

The erythrocyte deformability of blood samples, of diabetes mellitus (DM) patients with and without microangiopathic complications such as nephropathy and retinopathy, is determined and is compared with that of healthy control. The erythrocyte deformability is measured in terms of elongation index (EI) with microfluidic ektacytometer, which is very sensitive to detect changes in EI of erythrocytes due to hyperglycemic process. Each measurement of diffraction pattern of erythrocyte suspension in a highly viscous polyvinyl pyrroridone (PVP) solution in a disposable microchannel is carried out. The results show that EI is well correlated with the levels of glycated hemoglobin and creatinine, as determined from the blood samples of patients. A significant decrease in the EI in DM patients compared with that in normal control is observed. In patients with complications of chronic renal failure, end stage renal disease, retinopathy and with combination of retinopathy and nephropathy, the EI is significantly decreased in comparison with that of diabetes patients without these complications. Further reduction in EI is corresponded to the changes induced by the microangiopathy process despite the maintenance of blood glucose and glycated hemoglobin by drug therapy.

Authors+Show Affiliations

School of Mechanical Engineering, Kyungpook National University, Daegu 702-701, Korea. shins@knu.ac.krNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17361027

Citation

Shin, Sehyun, et al. "Progressive Impairment of Erythrocyte Deformability as Indicator of Microangiopathy in Type 2 Diabetes Mellitus." Clinical Hemorheology and Microcirculation, vol. 36, no. 3, 2007, pp. 253-61.
Shin S, Ku YH, Ho JX, et al. Progressive impairment of erythrocyte deformability as indicator of microangiopathy in type 2 diabetes mellitus. Clin Hemorheol Microcirc. 2007;36(3):253-61.
Shin, S., Ku, Y. H., Ho, J. X., Kim, Y. K., Suh, J. S., & Singh, M. (2007). Progressive impairment of erythrocyte deformability as indicator of microangiopathy in type 2 diabetes mellitus. Clinical Hemorheology and Microcirculation, 36(3), 253-61.
Shin S, et al. Progressive Impairment of Erythrocyte Deformability as Indicator of Microangiopathy in Type 2 Diabetes Mellitus. Clin Hemorheol Microcirc. 2007;36(3):253-61. PubMed PMID: 17361027.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Progressive impairment of erythrocyte deformability as indicator of microangiopathy in type 2 diabetes mellitus. AU - Shin,Sehyun, AU - Ku,Yun-Hee, AU - Ho,Jian-Xun, AU - Kim,Yu-Kyung, AU - Suh,Jang-Soo, AU - Singh,Megha, PY - 2007/3/16/pubmed PY - 2007/8/2/medline PY - 2007/3/16/entrez SP - 253 EP - 61 JF - Clinical hemorheology and microcirculation JO - Clin. Hemorheol. Microcirc. VL - 36 IS - 3 N2 - The erythrocyte deformability of blood samples, of diabetes mellitus (DM) patients with and without microangiopathic complications such as nephropathy and retinopathy, is determined and is compared with that of healthy control. The erythrocyte deformability is measured in terms of elongation index (EI) with microfluidic ektacytometer, which is very sensitive to detect changes in EI of erythrocytes due to hyperglycemic process. Each measurement of diffraction pattern of erythrocyte suspension in a highly viscous polyvinyl pyrroridone (PVP) solution in a disposable microchannel is carried out. The results show that EI is well correlated with the levels of glycated hemoglobin and creatinine, as determined from the blood samples of patients. A significant decrease in the EI in DM patients compared with that in normal control is observed. In patients with complications of chronic renal failure, end stage renal disease, retinopathy and with combination of retinopathy and nephropathy, the EI is significantly decreased in comparison with that of diabetes patients without these complications. Further reduction in EI is corresponded to the changes induced by the microangiopathy process despite the maintenance of blood glucose and glycated hemoglobin by drug therapy. SN - 1386-0291 UR - https://www.unboundmedicine.com/medline/citation/17361027/Progressive_impairment_of_erythrocyte_deformability_as_indicator_of_microangiopathy_in_type_2_diabetes_mellitus_ L2 - https://content.iospress.com/openurl?genre=article&issn=1386-0291&volume=36&issue=3&spage=253 DB - PRIME DP - Unbound Medicine ER -