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Effects of oral fat and glucose tolerance test on serum lipid profile, apolipoprotein, and CRP concentration, and insulin resistance in patients with polycystic ovary syndrome.
Fertil Steril 2007; 87(6):1363-8FS

Abstract

OBJECTIVE

To evaluate serum lipid responses and insulin resistance to a high-fat content meal in patients with polycystic ovary syndrome (PCOS).

DESIGN

Controlled clinical study.

SETTING

Healthy volunteers and patients with PCOS in clincial research.

PATIENT(S)

Twenty women with PCOS (22.7 +/- 4 years, body mass index [BMI]: 23.5 +/- 2.6 kg/m(2)) and 20 age- and BMI-matched control women (22.8 +/- 4, BMI: 23.1 +/- 3.1 kg/m(2)) were included in the study. Waist circumference, BMI, fat mass, fat percent, and fat-free mass were measured.

INTERVENTION(S)

A standard oral glucose tolerance test (75 g of glucose, 2 hours) was performed, and the area under the curve-glucose (AUC(glu)) and homeostasis model assessment of insulin resistance (HOMA-IR) were used for insulin resistance. An oral fat tolerance test (OFTT) with 500 mL standard fat meal (1493 kcal) was performed. With OFTT, both timely (at 0, second, fourth, sixth, and eighth hours) and AUC(triglyceride), AUC(total-cholesterol), AUC(VLDL-cholesterol), AUC(HDL-cholesterol), AUC(LDL-cholesterol), AUC(insulin), AUC(glucose), AUC(hs-CRP), AUC(LP(a)), AUC(ApoA1), and AUC(ApoB) responses were evaluated.

MAIN OUTCOME MEASURE(S)

Plasma lipid, insulin, and C-reactive protein levels.

RESULT(S)

Waist circumference, fat percent, and HOMA-IR values of PCOS patients were higher than those of control subjects. AUC(glu) values were also higher in patients with PCOS. After OFTT, AUC(triglyceride), AUC(total cholesterol), and AUC(VLDL) values were higher in patients with PCOS.

CONCLUSION(S)

Patients with PCOS have insulin resistance and prolonged lipid response to OFTT. These exaggerated responses may cause early atherogenesis in these patients.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Dicle University School of Medicine, Diyarbakir, Turkey. mbahceci@dicle.edu.trNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17362944

Citation

Bahceci, Mithat, et al. "Effects of Oral Fat and Glucose Tolerance Test On Serum Lipid Profile, Apolipoprotein, and CRP Concentration, and Insulin Resistance in Patients With Polycystic Ovary Syndrome." Fertility and Sterility, vol. 87, no. 6, 2007, pp. 1363-8.
Bahceci M, Aydemir M, Tuzcu A. Effects of oral fat and glucose tolerance test on serum lipid profile, apolipoprotein, and CRP concentration, and insulin resistance in patients with polycystic ovary syndrome. Fertil Steril. 2007;87(6):1363-8.
Bahceci, M., Aydemir, M., & Tuzcu, A. (2007). Effects of oral fat and glucose tolerance test on serum lipid profile, apolipoprotein, and CRP concentration, and insulin resistance in patients with polycystic ovary syndrome. Fertility and Sterility, 87(6), pp. 1363-8.
Bahceci M, Aydemir M, Tuzcu A. Effects of Oral Fat and Glucose Tolerance Test On Serum Lipid Profile, Apolipoprotein, and CRP Concentration, and Insulin Resistance in Patients With Polycystic Ovary Syndrome. Fertil Steril. 2007;87(6):1363-8. PubMed PMID: 17362944.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of oral fat and glucose tolerance test on serum lipid profile, apolipoprotein, and CRP concentration, and insulin resistance in patients with polycystic ovary syndrome. AU - Bahceci,Mithat, AU - Aydemir,Mehmet, AU - Tuzcu,Alpaslan, Y1 - 2007/03/23/ PY - 2006/03/21/received PY - 2006/10/20/revised PY - 2006/11/10/accepted PY - 2007/3/17/pubmed PY - 2007/9/15/medline PY - 2007/3/17/entrez SP - 1363 EP - 8 JF - Fertility and sterility JO - Fertil. Steril. VL - 87 IS - 6 N2 - OBJECTIVE: To evaluate serum lipid responses and insulin resistance to a high-fat content meal in patients with polycystic ovary syndrome (PCOS). DESIGN: Controlled clinical study. SETTING: Healthy volunteers and patients with PCOS in clincial research. PATIENT(S): Twenty women with PCOS (22.7 +/- 4 years, body mass index [BMI]: 23.5 +/- 2.6 kg/m(2)) and 20 age- and BMI-matched control women (22.8 +/- 4, BMI: 23.1 +/- 3.1 kg/m(2)) were included in the study. Waist circumference, BMI, fat mass, fat percent, and fat-free mass were measured. INTERVENTION(S): A standard oral glucose tolerance test (75 g of glucose, 2 hours) was performed, and the area under the curve-glucose (AUC(glu)) and homeostasis model assessment of insulin resistance (HOMA-IR) were used for insulin resistance. An oral fat tolerance test (OFTT) with 500 mL standard fat meal (1493 kcal) was performed. With OFTT, both timely (at 0, second, fourth, sixth, and eighth hours) and AUC(triglyceride), AUC(total-cholesterol), AUC(VLDL-cholesterol), AUC(HDL-cholesterol), AUC(LDL-cholesterol), AUC(insulin), AUC(glucose), AUC(hs-CRP), AUC(LP(a)), AUC(ApoA1), and AUC(ApoB) responses were evaluated. MAIN OUTCOME MEASURE(S): Plasma lipid, insulin, and C-reactive protein levels. RESULT(S): Waist circumference, fat percent, and HOMA-IR values of PCOS patients were higher than those of control subjects. AUC(glu) values were also higher in patients with PCOS. After OFTT, AUC(triglyceride), AUC(total cholesterol), and AUC(VLDL) values were higher in patients with PCOS. CONCLUSION(S): Patients with PCOS have insulin resistance and prolonged lipid response to OFTT. These exaggerated responses may cause early atherogenesis in these patients. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/17362944/Effects_of_oral_fat_and_glucose_tolerance_test_on_serum_lipid_profile_apolipoprotein_and_CRP_concentration_and_insulin_resistance_in_patients_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(06)04513-4 DB - PRIME DP - Unbound Medicine ER -