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Geranyl flavonoids from the leaves of Artocarpus altilis.
Phytochemistry. 2007 May; 68(9):1300-6.P

Abstract

Five geranyl dihydrochalcones, 1-(2,4-dihydroxyphenyl)-3-{4-hydroxy-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo[b,d]pyran-5-yl}-1-propanone (2), 1-(2,4-dihydroxyphenyl)-3-[3,4-dihydro-3,8-dihydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone (4), 1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(3,4-epoxy-4-methyl-1-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone (5), 1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-hydroxy-4-methyl-2-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone (8), and 2-[6-hydroxy-3,7-dimethylocta-2(E),7-dienyl]-2',3,4,4'-tetrahydroxydihydrochalcone (9), along with four known geranyl flavonoids (1, 3, 6, 7), were isolated from the leaves of Artocarpus altilis. Their structures were established by spectroscopic means and by comparison with the literature values. Compounds 2, 4, and 9 exhibited moderate cytotoxicity against SPC-A-1, SW-480, and SMMC-7721 human cancer cells.

Authors+Show Affiliations

Department of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education, Zhejiang University, Hangzhou 310027, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17363017

Citation

Wang, Yu, et al. "Geranyl Flavonoids From the Leaves of Artocarpus Altilis." Phytochemistry, vol. 68, no. 9, 2007, pp. 1300-6.
Wang Y, Xu K, Lin L, et al. Geranyl flavonoids from the leaves of Artocarpus altilis. Phytochemistry. 2007;68(9):1300-6.
Wang, Y., Xu, K., Lin, L., Pan, Y., & Zheng, X. (2007). Geranyl flavonoids from the leaves of Artocarpus altilis. Phytochemistry, 68(9), 1300-6.
Wang Y, et al. Geranyl Flavonoids From the Leaves of Artocarpus Altilis. Phytochemistry. 2007;68(9):1300-6. PubMed PMID: 17363017.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Geranyl flavonoids from the leaves of Artocarpus altilis. AU - Wang,Yu, AU - Xu,Kedi, AU - Lin,Lin, AU - Pan,Yuanjiang, AU - Zheng,Xiaoxiang, Y1 - 2007/03/23/ PY - 2006/08/19/received PY - 2007/01/01/revised PY - 2007/01/18/accepted PY - 2007/3/17/pubmed PY - 2007/7/26/medline PY - 2007/3/17/entrez SP - 1300 EP - 6 JF - Phytochemistry JO - Phytochemistry VL - 68 IS - 9 N2 - Five geranyl dihydrochalcones, 1-(2,4-dihydroxyphenyl)-3-{4-hydroxy-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo[b,d]pyran-5-yl}-1-propanone (2), 1-(2,4-dihydroxyphenyl)-3-[3,4-dihydro-3,8-dihydroxy-2-methyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone (4), 1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(3,4-epoxy-4-methyl-1-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone (5), 1-(2,4-dihydroxyphenyl)-3-[8-hydroxy-2-methyl-2-(4-hydroxy-4-methyl-2-pentenyl)-2H-1-benzopyran-5-yl]-1-propanone (8), and 2-[6-hydroxy-3,7-dimethylocta-2(E),7-dienyl]-2',3,4,4'-tetrahydroxydihydrochalcone (9), along with four known geranyl flavonoids (1, 3, 6, 7), were isolated from the leaves of Artocarpus altilis. Their structures were established by spectroscopic means and by comparison with the literature values. Compounds 2, 4, and 9 exhibited moderate cytotoxicity against SPC-A-1, SW-480, and SMMC-7721 human cancer cells. SN - 0031-9422 UR - https://www.unboundmedicine.com/medline/citation/17363017/Geranyl_flavonoids_from_the_leaves_of_Artocarpus_altilis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0031-9422(07)00048-9 DB - PRIME DP - Unbound Medicine ER -