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Cost-effectiveness of a folic acid fortification program in Chile.
Health Policy. 2007 Oct; 83(2-3):295-303.HP

Abstract

OBJECTIVE

Periconceptional intake of folic acid reduces the risk of neural tube defects (NTDs), a frequent birth defect that can cause significant infant mortality and disability. In Chile, fortification of wheat flour with folic acid has resulted in significant reduction in the risk of anencephaly and spina bifida. We investigated the cost-effectiveness implications of this policy.

METHODS

We conducted an ex-post economic analysis of this intervention. Estimates of the effect of fortification in decreasing NTDs and deaths were derived from a prospective evaluation. The costs of fortification and provision of medical care to children with spina bifida in Chile were based on primary data collection.

FINDINGS

The intervention costs per NTD case and infant death averted were I$ 1200 and 11,000, respectively. The cost per DALY averted was I$ 89, 0.8% of Chile's GDP per capita. Taking into account averted costs of care, fortification resulted in net cost savings of I$ 2.3 million.

CONCLUSION

Fortification of wheat flour with folic acid is a cost-effective intervention in Chile, a middle income country in the post-epidemiological transition. This result supports the continuation of the Chile fortification program and constitutes valuable information for policy makers in other countries to consider.

Authors+Show Affiliations

Instituto de Nutrición y Tecnología de los Alimentos (INTA), Universidad de Chile, Chile. adolfo_llanos@pediatrix.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Evaluation Study
Journal Article

Language

eng

PubMed ID

17363103

Citation

Llanos, Adolfo, et al. "Cost-effectiveness of a Folic Acid Fortification Program in Chile." Health Policy (Amsterdam, Netherlands), vol. 83, no. 2-3, 2007, pp. 295-303.
Llanos A, Hertrampf E, Cortes F, et al. Cost-effectiveness of a folic acid fortification program in Chile. Health Policy. 2007;83(2-3):295-303.
Llanos, A., Hertrampf, E., Cortes, F., Pardo, A., Grosse, S. D., & Uauy, R. (2007). Cost-effectiveness of a folic acid fortification program in Chile. Health Policy (Amsterdam, Netherlands), 83(2-3), 295-303.
Llanos A, et al. Cost-effectiveness of a Folic Acid Fortification Program in Chile. Health Policy. 2007;83(2-3):295-303. PubMed PMID: 17363103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cost-effectiveness of a folic acid fortification program in Chile. AU - Llanos,Adolfo, AU - Hertrampf,Eva, AU - Cortes,Fanny, AU - Pardo,Andrea, AU - Grosse,Scott D, AU - Uauy,Ricardo, Y1 - 2007/03/23/ PY - 2006/08/08/received PY - 2007/01/24/revised PY - 2007/01/24/accepted PY - 2007/3/17/pubmed PY - 2008/4/26/medline PY - 2007/3/17/entrez SP - 295 EP - 303 JF - Health policy (Amsterdam, Netherlands) JO - Health Policy VL - 83 IS - 2-3 N2 - OBJECTIVE: Periconceptional intake of folic acid reduces the risk of neural tube defects (NTDs), a frequent birth defect that can cause significant infant mortality and disability. In Chile, fortification of wheat flour with folic acid has resulted in significant reduction in the risk of anencephaly and spina bifida. We investigated the cost-effectiveness implications of this policy. METHODS: We conducted an ex-post economic analysis of this intervention. Estimates of the effect of fortification in decreasing NTDs and deaths were derived from a prospective evaluation. The costs of fortification and provision of medical care to children with spina bifida in Chile were based on primary data collection. FINDINGS: The intervention costs per NTD case and infant death averted were I$ 1200 and 11,000, respectively. The cost per DALY averted was I$ 89, 0.8% of Chile's GDP per capita. Taking into account averted costs of care, fortification resulted in net cost savings of I$ 2.3 million. CONCLUSION: Fortification of wheat flour with folic acid is a cost-effective intervention in Chile, a middle income country in the post-epidemiological transition. This result supports the continuation of the Chile fortification program and constitutes valuable information for policy makers in other countries to consider. SN - 0168-8510 UR - https://www.unboundmedicine.com/medline/citation/17363103/Cost_effectiveness_of_a_folic_acid_fortification_program_in_Chile_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8510(07)00032-2 DB - PRIME DP - Unbound Medicine ER -