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Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes.
Endothelium. 2007 Jan-Feb; 14(1):45-51.E

Abstract

The authors hypothesized that matrix metalloproteinase (MMP)-2, -9, and tissue inhibitor metalloproteinase (TIMP)-1, -2 would be abnormal in acute coronary syndromes (ACSs). MMP-2, -9, and TIMP-1, -2 plasma levels were measured in diabetic patients with ACSs compared to nondiabetic patients with ACSs. A total of 46 diabetic and 78 nondiabetic patients with ACSs were enrolled. The following parameters were measured: body mass index (BMI), glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment index (HOMA index), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (Tg), lipoprotein(a) [Lp(a)], plasminogen activator inhibitor-1 (PAI-1), homocysteine (Hct), fibrinogen (Fg), high-sensitivity C-reactive protein (hs-CRP), and plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2. Significant HbA1c, FPG, FPI, HOMA index, DBP, Tg, Hct, and Fg increases were present in the diabetic group with ACSs, whereas hs-CRP was lower in these patients compared to nondiabetic patients with ACSs. MMP-9, TIMP-1, and TIMP-2 plasma levels were higher in diabetic patients with ACSs compared to nondiabetic patients with ACSs. MMP-9, TIMP-1, and TIMP-2 plasma levels were increased in diabetic patients with ACSs, which may reflect abnormal extracellular matrix metabolism in diabetes during acute event.

Authors+Show Affiliations

Department of Internal Medicine and Therapeutics, University of Pavia, Fondazione IRCCS Policlinico S. Matteo, Pavia, Italy. giuseppe.derosa@unipv.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

17364896

Citation

Derosa, Giuseppe, et al. "Metalloproteinase-2 and -9 in Diabetic and Nondiabetic Subjects During Acute Coronary Syndromes." Endothelium : Journal of Endothelial Cell Research, vol. 14, no. 1, 2007, pp. 45-51.
Derosa G, Cicero AF, Scalise F, et al. Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes. Endothelium. 2007;14(1):45-51.
Derosa, G., Cicero, A. F., Scalise, F., Avanzini, M. A., Tinelli, C., Piccinni, M. N., Peros, E., Geroldi, D., Fogari, E., & D'Angelo, A. (2007). Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes. Endothelium : Journal of Endothelial Cell Research, 14(1), 45-51.
Derosa G, et al. Metalloproteinase-2 and -9 in Diabetic and Nondiabetic Subjects During Acute Coronary Syndromes. Endothelium. 2007 Jan-Feb;14(1):45-51. PubMed PMID: 17364896.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metalloproteinase-2 and -9 in diabetic and nondiabetic subjects during acute coronary syndromes. AU - Derosa,Giuseppe, AU - Cicero,Arrigo F G, AU - Scalise,Filippo, AU - Avanzini,Maria A, AU - Tinelli,Carmine, AU - Piccinni,Mario N, AU - Peros,Emmanouil, AU - Geroldi,Diego, AU - Fogari,Elena, AU - D'Angelo,Angela, PY - 2007/3/17/pubmed PY - 2007/6/7/medline PY - 2007/3/17/entrez SP - 45 EP - 51 JF - Endothelium : journal of endothelial cell research JO - Endothelium VL - 14 IS - 1 N2 - The authors hypothesized that matrix metalloproteinase (MMP)-2, -9, and tissue inhibitor metalloproteinase (TIMP)-1, -2 would be abnormal in acute coronary syndromes (ACSs). MMP-2, -9, and TIMP-1, -2 plasma levels were measured in diabetic patients with ACSs compared to nondiabetic patients with ACSs. A total of 46 diabetic and 78 nondiabetic patients with ACSs were enrolled. The following parameters were measured: body mass index (BMI), glycosylated hemoglobin (HbA1c), fasting plasma glucose (FPG), fasting plasma insulin (FPI), homeostasis model assessment index (HOMA index), systolic blood pressure (SBP), diastolic blood pressure (DBP), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (Tg), lipoprotein(a) [Lp(a)], plasminogen activator inhibitor-1 (PAI-1), homocysteine (Hct), fibrinogen (Fg), high-sensitivity C-reactive protein (hs-CRP), and plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2. Significant HbA1c, FPG, FPI, HOMA index, DBP, Tg, Hct, and Fg increases were present in the diabetic group with ACSs, whereas hs-CRP was lower in these patients compared to nondiabetic patients with ACSs. MMP-9, TIMP-1, and TIMP-2 plasma levels were higher in diabetic patients with ACSs compared to nondiabetic patients with ACSs. MMP-9, TIMP-1, and TIMP-2 plasma levels were increased in diabetic patients with ACSs, which may reflect abnormal extracellular matrix metabolism in diabetes during acute event. SN - 1062-3329 UR - https://www.unboundmedicine.com/medline/citation/17364896/Metalloproteinase_2_and__9_in_diabetic_and_nondiabetic_subjects_during_acute_coronary_syndromes_ L2 - https://medlineplus.gov/diabetestype2.html DB - PRIME DP - Unbound Medicine ER -