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Tissue distribution and oral dose effects of microcystin in the freshwater pulmonate snail Lymnaea stagnalis jugularis (Say).
J Toxicol Environ Health A. 2007 Apr 01; 70(7):620-6.JT

Abstract

Microcystin (MC) concentrations were measured in the alimentary tract, digestive gland, and remaining visceral mass of adult pulmonate snails (Lymnaea stagnalis) exposed to cyanobacteria known to contain MC. The highest proportion of total body MC content was measured within the alimentary tract (83%), though an appreciable proportion (17%) was also found within the digestive gland tissue. This provides conclusive evidence for the limited digestion of toxic cyanobacteria and subsequent uptake and accumulation of MC by the digestive gland of L. stagnalis. Additionally, pure microcystin-LR was orally administered to adult L. stagnalis to investigate the potential for toxic effects. Exposure to microcystin-LR induced histopathological alterations of the digestive glands consistent with those reported elsewhere for mammals and fish, indicating a common mode of toxicity to both vertebrates and invertebrates.

Authors+Show Affiliations

Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada. ron.zurawell@gov.ab.caNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17365616

Citation

Zurawell, Ronald W., et al. "Tissue Distribution and Oral Dose Effects of Microcystin in the Freshwater Pulmonate Snail Lymnaea Stagnalis Jugularis (Say)." Journal of Toxicology and Environmental Health. Part A, vol. 70, no. 7, 2007, pp. 620-6.
Zurawell RW, Goldberg JI, Holmes CF, et al. Tissue distribution and oral dose effects of microcystin in the freshwater pulmonate snail Lymnaea stagnalis jugularis (Say). J Toxicol Environ Health A. 2007;70(7):620-6.
Zurawell, R. W., Goldberg, J. I., Holmes, C. F., & Prepas, E. E. (2007). Tissue distribution and oral dose effects of microcystin in the freshwater pulmonate snail Lymnaea stagnalis jugularis (Say). Journal of Toxicology and Environmental Health. Part A, 70(7), 620-6.
Zurawell RW, et al. Tissue Distribution and Oral Dose Effects of Microcystin in the Freshwater Pulmonate Snail Lymnaea Stagnalis Jugularis (Say). J Toxicol Environ Health A. 2007 Apr 1;70(7):620-6. PubMed PMID: 17365616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tissue distribution and oral dose effects of microcystin in the freshwater pulmonate snail Lymnaea stagnalis jugularis (Say). AU - Zurawell,Ronald W, AU - Goldberg,Jeff I, AU - Holmes,Charles F B, AU - Prepas,Ellie E, PY - 2007/3/17/pubmed PY - 2007/4/3/medline PY - 2007/3/17/entrez SP - 620 EP - 6 JF - Journal of toxicology and environmental health. Part A JO - J Toxicol Environ Health A VL - 70 IS - 7 N2 - Microcystin (MC) concentrations were measured in the alimentary tract, digestive gland, and remaining visceral mass of adult pulmonate snails (Lymnaea stagnalis) exposed to cyanobacteria known to contain MC. The highest proportion of total body MC content was measured within the alimentary tract (83%), though an appreciable proportion (17%) was also found within the digestive gland tissue. This provides conclusive evidence for the limited digestion of toxic cyanobacteria and subsequent uptake and accumulation of MC by the digestive gland of L. stagnalis. Additionally, pure microcystin-LR was orally administered to adult L. stagnalis to investigate the potential for toxic effects. Exposure to microcystin-LR induced histopathological alterations of the digestive glands consistent with those reported elsewhere for mammals and fish, indicating a common mode of toxicity to both vertebrates and invertebrates. SN - 1528-7394 UR - https://www.unboundmedicine.com/medline/citation/17365616/Tissue_distribution_and_oral_dose_effects_of_microcystin_in_the_freshwater_pulmonate_snail_Lymnaea_stagnalis_jugularis__Say__ L2 - https://www.tandfonline.com/doi/full/10.1080/15287390600974510 DB - PRIME DP - Unbound Medicine ER -