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Serum leptin, resistin, and lipid levels in patients with end stage renal failure with regard to dialysis modality.
Ren Fail. 2007; 29(2):147-54.RF

Abstract

Little information is available on the relationship between serum resistin levels and other adipokines with serum lipid levels and insulin resistance in uremic patients under different dialysis modalities.

METHODS

This study investigated the effects of dialysis modality on serum leptin, adiponectin, resistin, interleukin 6 (IL-6), and tumor necrosis factor (TNF) alpha levels in age, sex, and total adipose tissue mass (TATM); matched 30 hemodialysis (HD) patients, 30 continuous peritoneal dialysis (CAPD) patients, and 30 healthy controls; and evaluated the relationship between these adipokines and dyslipidemia and insulin resistance.

RESULTS

Serum resistin, adiponectin, IL-6, TNF-alpha, and high sensitive C reactive protein (hsCRP) levels were significantly increased in dialysis patients compared to controls (p < 0.05). In CAPD patients, serum leptin, resistin, triglycerides, and total cholesterol levels were higher than those in HD patients (p < 0.05). Leptin levels were positively correlated with TATM, serum triglycerides, total cholesterol, and low density lipoprotein (LDLc) levels in both dialysis groups. Resistin levels were found to positively correlate with TATM and triglycerides in CAPD patients. No relationship was found between the homeostasis model assessment-insulin resistance index (HOMA-IR) and adipokines studied.

CONCLUSION

Serum leptin, resistin, triglycerides, and total cholesterol levels were higher in CAPD patients. Leptin levels were positively correlated with TATM, serum triglycerides, total cholesterol, and LDLc levels in dialysis patients. Resistin levels were positively correlated with TATM and triglycerides in CAPD patients. Glucose load during CAPD may be an important factor in increased in leptin, resistin, triglycerides, and total cholesterol levels in CAPD patients. These results highlight the importance of leptin and resistin as determinants of dyslipidemia, especially in CAPD patients.

Authors+Show Affiliations

Biochemistry Department, Turgut Ozal Medical Center of Inonu University Medical Faculty, Malatya, Turkey. taskapanmc@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17365928

Citation

Taskapan, M Cagatay, et al. "Serum Leptin, Resistin, and Lipid Levels in Patients With End Stage Renal Failure With Regard to Dialysis Modality." Renal Failure, vol. 29, no. 2, 2007, pp. 147-54.
Taskapan MC, Taskapan H, Sahin I, et al. Serum leptin, resistin, and lipid levels in patients with end stage renal failure with regard to dialysis modality. Ren Fail. 2007;29(2):147-54.
Taskapan, M. C., Taskapan, H., Sahin, I., Keskin, L., Atmaca, H., & Ozyalin, F. (2007). Serum leptin, resistin, and lipid levels in patients with end stage renal failure with regard to dialysis modality. Renal Failure, 29(2), 147-54.
Taskapan MC, et al. Serum Leptin, Resistin, and Lipid Levels in Patients With End Stage Renal Failure With Regard to Dialysis Modality. Ren Fail. 2007;29(2):147-54. PubMed PMID: 17365928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum leptin, resistin, and lipid levels in patients with end stage renal failure with regard to dialysis modality. AU - Taskapan,M Cagatay, AU - Taskapan,Hulya, AU - Sahin,Ibrahim, AU - Keskin,Lezzan, AU - Atmaca,Hasan, AU - Ozyalin,Fatma, PY - 2007/3/17/pubmed PY - 2007/5/15/medline PY - 2007/3/17/entrez SP - 147 EP - 54 JF - Renal failure JO - Ren Fail VL - 29 IS - 2 N2 - UNLABELLED: Little information is available on the relationship between serum resistin levels and other adipokines with serum lipid levels and insulin resistance in uremic patients under different dialysis modalities. METHODS: This study investigated the effects of dialysis modality on serum leptin, adiponectin, resistin, interleukin 6 (IL-6), and tumor necrosis factor (TNF) alpha levels in age, sex, and total adipose tissue mass (TATM); matched 30 hemodialysis (HD) patients, 30 continuous peritoneal dialysis (CAPD) patients, and 30 healthy controls; and evaluated the relationship between these adipokines and dyslipidemia and insulin resistance. RESULTS: Serum resistin, adiponectin, IL-6, TNF-alpha, and high sensitive C reactive protein (hsCRP) levels were significantly increased in dialysis patients compared to controls (p < 0.05). In CAPD patients, serum leptin, resistin, triglycerides, and total cholesterol levels were higher than those in HD patients (p < 0.05). Leptin levels were positively correlated with TATM, serum triglycerides, total cholesterol, and low density lipoprotein (LDLc) levels in both dialysis groups. Resistin levels were found to positively correlate with TATM and triglycerides in CAPD patients. No relationship was found between the homeostasis model assessment-insulin resistance index (HOMA-IR) and adipokines studied. CONCLUSION: Serum leptin, resistin, triglycerides, and total cholesterol levels were higher in CAPD patients. Leptin levels were positively correlated with TATM, serum triglycerides, total cholesterol, and LDLc levels in dialysis patients. Resistin levels were positively correlated with TATM and triglycerides in CAPD patients. Glucose load during CAPD may be an important factor in increased in leptin, resistin, triglycerides, and total cholesterol levels in CAPD patients. These results highlight the importance of leptin and resistin as determinants of dyslipidemia, especially in CAPD patients. SN - 0886-022X UR - https://www.unboundmedicine.com/medline/citation/17365928/Serum_leptin_resistin_and_lipid_levels_in_patients_with_end_stage_renal_failure_with_regard_to_dialysis_modality_ L2 - http://www.tandfonline.com/doi/full/10.1080/08860220601095827 DB - PRIME DP - Unbound Medicine ER -