Tags

Type your tag names separated by a space and hit enter

Relationships between brain natriuretic peptide, troponin I and QT dispersion in asymptomatic dialysis patients.
Ren Fail. 2007; 29(2):221-5.RF

Abstract

OBJECTIVES

The relationships between increased wall stress, myocyte death, and ventricular repolarization instability in patients with heart failure were reported.

DESIGN AND METHODS

The relationships between brain natriuretic peptide (BNP), a predictor of increased wall stress of hearth; troponin I (cTnI), a predictor of myocyte death; and QT dispersion (QTd), a reflection of ventricular repolarization instability were evaluated in age- and sex-matched asymptomatic 29 hemodialysis (HD) patients and 26 peritoneal dialysis (PD) patients, and the finding were compared.

RESULTS

Serum BNP and cTnI levels in HD patients (722.9 +/- 907.9 pg/mL, 0.05 +/- 0.07 microg/L, respectively), just before HD, were significantly higher than those of PD patients (255.4 +/- 463.7 pg/mL, 0.02 +/- 0.02 microg/L, respectively; p < 0.05). There was no significant difference between groups with regard to corrected QTd and maximum and minimum QT intervals (p > 0.05). Serum cTnI levels were significantly and positively correlated with serum BNP levels in both dialysis groups (r = 0.447, p = 0.048). No relationship was found between plasma BNP and ECG parameters studied in both groups (p > 0.05).

CONCLUSION

Increased serum cTnI levels were associated with elevated BNP levels in both dialysis groups. The increases in BNP and troponin I are more likely to reflect hypervolemia. Although CAPD patients were receiving dialysis daily and HD patients were more hypervolemic, CAPD patients have similar QTdc and accordingly a similar tendency toward arrhythmias. This suggests that factors other than electromechanical interaction may be important in determining the QT interval length in patients on dialysis.

Authors+Show Affiliations

Biochemistry Department, Turgut Ozal Medical Center of Inonu University Medical Faculty, Malatya, Turkey. taskapanmc@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17365940

Citation

Taskapan, M Cagatay, et al. "Relationships Between Brain Natriuretic Peptide, Troponin I and QT Dispersion in Asymptomatic Dialysis Patients." Renal Failure, vol. 29, no. 2, 2007, pp. 221-5.
Taskapan MC, Taskapan H, Ulutas O, et al. Relationships between brain natriuretic peptide, troponin I and QT dispersion in asymptomatic dialysis patients. Ren Fail. 2007;29(2):221-5.
Taskapan, M. C., Taskapan, H., Ulutas, O., Orhan, M., & Sahin, I. (2007). Relationships between brain natriuretic peptide, troponin I and QT dispersion in asymptomatic dialysis patients. Renal Failure, 29(2), 221-5.
Taskapan MC, et al. Relationships Between Brain Natriuretic Peptide, Troponin I and QT Dispersion in Asymptomatic Dialysis Patients. Ren Fail. 2007;29(2):221-5. PubMed PMID: 17365940.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationships between brain natriuretic peptide, troponin I and QT dispersion in asymptomatic dialysis patients. AU - Taskapan,M Cagatay, AU - Taskapan,Hulya, AU - Ulutas,Ozkan, AU - Orhan,Mesut, AU - Sahin,Ibrahim, PY - 2007/3/17/pubmed PY - 2007/5/15/medline PY - 2007/3/17/entrez SP - 221 EP - 5 JF - Renal failure JO - Ren Fail VL - 29 IS - 2 N2 - OBJECTIVES: The relationships between increased wall stress, myocyte death, and ventricular repolarization instability in patients with heart failure were reported. DESIGN AND METHODS: The relationships between brain natriuretic peptide (BNP), a predictor of increased wall stress of hearth; troponin I (cTnI), a predictor of myocyte death; and QT dispersion (QTd), a reflection of ventricular repolarization instability were evaluated in age- and sex-matched asymptomatic 29 hemodialysis (HD) patients and 26 peritoneal dialysis (PD) patients, and the finding were compared. RESULTS: Serum BNP and cTnI levels in HD patients (722.9 +/- 907.9 pg/mL, 0.05 +/- 0.07 microg/L, respectively), just before HD, were significantly higher than those of PD patients (255.4 +/- 463.7 pg/mL, 0.02 +/- 0.02 microg/L, respectively; p < 0.05). There was no significant difference between groups with regard to corrected QTd and maximum and minimum QT intervals (p > 0.05). Serum cTnI levels were significantly and positively correlated with serum BNP levels in both dialysis groups (r = 0.447, p = 0.048). No relationship was found between plasma BNP and ECG parameters studied in both groups (p > 0.05). CONCLUSION: Increased serum cTnI levels were associated with elevated BNP levels in both dialysis groups. The increases in BNP and troponin I are more likely to reflect hypervolemia. Although CAPD patients were receiving dialysis daily and HD patients were more hypervolemic, CAPD patients have similar QTdc and accordingly a similar tendency toward arrhythmias. This suggests that factors other than electromechanical interaction may be important in determining the QT interval length in patients on dialysis. SN - 0886-022X UR - https://www.unboundmedicine.com/medline/citation/17365940/Relationships_between_brain_natriuretic_peptide_troponin_I_and_QT_dispersion_in_asymptomatic_dialysis_patients_ L2 - https://www.tandfonline.com/doi/full/10.1080/08860220601098953 DB - PRIME DP - Unbound Medicine ER -