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High plasma levels of CD40 are associated with low coenzyme Q and vitamin E content of low-density lipoprotein in healthy men.
Scand J Clin Lab Invest. 2007; 67(2):115-22.SJ

Abstract

OBJECTIVE

There is a growing body of evidence to suggest that low-density lipoprotein (LDL) cholesterol, inflammation and oxidative stress are pivotal in the development of cardiovascular disease, but their interconnections are not well known. The objective of this study was to determine whether immunological activation, reflected by the plasma levels of soluble CD40 (sCD40), interleukin (IL)-1beta, tumor necrosis factor-alpha and IL-6 are associated with the antioxidant potential of LDL particles or with common lipid, immunological or thrombotic markers in 51 young healthy men.

MATERIAL AND METHODS

We determined the coenzyme Q level from an oxidized LDL fraction, obtaining the concentration for ubiquinone, which indicates total coenzyme Q levels.

RESULTS

The plasma level of sCD40 was negatively correlated with LDL ubiquinone (r=-0.45, p=0.001) and E vitamin (r=-0.37, p=0.008) and positively correlated with plasma concentration of plasminogen activator inhibitor-1 (PAI-1, r=0.52, p=0.002) and caspase-1 (r=0.40, p=0.004). No correlation was detected between sCD40 and plasma lipid or C-reactive protein concentrations. As sCD40 was strongly correlated with the content of LDL ubiquinone and vitamin E, their values were compared according to groups formed by sCD40 tertiles. Analysis of variance showed that there were significant differences in LDL ubiquinone (p<0.0001) and vitamin E (p=0.004) concentrations between sCD40 tertiles.

CONCLUSIONS

The data indicate that increased activation of the CD40 system is related to low levels of LDL ubiquinone and vitamin E. This suggests that chronic or increased immunological activation may consume the antioxidant potential of LDL particles.

Authors+Show Affiliations

Laboratory of Atherosclerosis Genetics, Center for Laboratory Medicine, Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland. mari.luomala@uta.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17365991

Citation

Luomala, M, et al. "High Plasma Levels of CD40 Are Associated With Low Coenzyme Q and Vitamin E Content of Low-density Lipoprotein in Healthy Men." Scandinavian Journal of Clinical and Laboratory Investigation, vol. 67, no. 2, 2007, pp. 115-22.
Luomala M, Laaksonen R, Janatuinen T, et al. High plasma levels of CD40 are associated with low coenzyme Q and vitamin E content of low-density lipoprotein in healthy men. Scand J Clin Lab Invest. 2007;67(2):115-22.
Luomala, M., Laaksonen, R., Janatuinen, T., Vesalainen, R., Nuutila, P., Saarela, M., Mattila, K., Kalijärvi, M., Solakivi, T., Knuuti, J., Hurme, M., & Lehtimäki, T. (2007). High plasma levels of CD40 are associated with low coenzyme Q and vitamin E content of low-density lipoprotein in healthy men. Scandinavian Journal of Clinical and Laboratory Investigation, 67(2), 115-22.
Luomala M, et al. High Plasma Levels of CD40 Are Associated With Low Coenzyme Q and Vitamin E Content of Low-density Lipoprotein in Healthy Men. Scand J Clin Lab Invest. 2007;67(2):115-22. PubMed PMID: 17365991.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High plasma levels of CD40 are associated with low coenzyme Q and vitamin E content of low-density lipoprotein in healthy men. AU - Luomala,M, AU - Laaksonen,R, AU - Janatuinen,T, AU - Vesalainen,R, AU - Nuutila,P, AU - Saarela,M, AU - Mattila,K, AU - Kalijärvi,M, AU - Solakivi,T, AU - Knuuti,J, AU - Hurme,M, AU - Lehtimäki,T, PY - 2007/3/17/pubmed PY - 2007/5/9/medline PY - 2007/3/17/entrez SP - 115 EP - 22 JF - Scandinavian journal of clinical and laboratory investigation JO - Scand J Clin Lab Invest VL - 67 IS - 2 N2 - OBJECTIVE: There is a growing body of evidence to suggest that low-density lipoprotein (LDL) cholesterol, inflammation and oxidative stress are pivotal in the development of cardiovascular disease, but their interconnections are not well known. The objective of this study was to determine whether immunological activation, reflected by the plasma levels of soluble CD40 (sCD40), interleukin (IL)-1beta, tumor necrosis factor-alpha and IL-6 are associated with the antioxidant potential of LDL particles or with common lipid, immunological or thrombotic markers in 51 young healthy men. MATERIAL AND METHODS: We determined the coenzyme Q level from an oxidized LDL fraction, obtaining the concentration for ubiquinone, which indicates total coenzyme Q levels. RESULTS: The plasma level of sCD40 was negatively correlated with LDL ubiquinone (r=-0.45, p=0.001) and E vitamin (r=-0.37, p=0.008) and positively correlated with plasma concentration of plasminogen activator inhibitor-1 (PAI-1, r=0.52, p=0.002) and caspase-1 (r=0.40, p=0.004). No correlation was detected between sCD40 and plasma lipid or C-reactive protein concentrations. As sCD40 was strongly correlated with the content of LDL ubiquinone and vitamin E, their values were compared according to groups formed by sCD40 tertiles. Analysis of variance showed that there were significant differences in LDL ubiquinone (p<0.0001) and vitamin E (p=0.004) concentrations between sCD40 tertiles. CONCLUSIONS: The data indicate that increased activation of the CD40 system is related to low levels of LDL ubiquinone and vitamin E. This suggests that chronic or increased immunological activation may consume the antioxidant potential of LDL particles. SN - 0036-5513 UR - https://www.unboundmedicine.com/medline/citation/17365991/High_plasma_levels_of_CD40_are_associated_with_low_coenzyme_Q_and_vitamin_E_content_of_low_density_lipoprotein_in_healthy_men_ L2 - https://www.tandfonline.com/doi/full/10.1080/00365510600979394 DB - PRIME DP - Unbound Medicine ER -