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Flavonoids from the flower of Rhododendron yedoense var. poukhanense and their antioxidant activities.
Arch Pharm Res. 2007 Feb; 30(2):146-50.AP

Abstract

Antioxidant flavonoids have been isolated from the flower of Rhododendron yedoense var. poukhanense. One new flavonoid and three known flavonoids, quercetin-5-O-beta-D-glucopyranoside (1), quercetin (3), and quercitrin (4), were isolated from the butanol and ethyl acetate extracts of the plant. The new flavonoid was identified as myricitrin-5-methyl ether (2). The isolation of these flavonoids from this plant, for the first time, is a valuable finding. The flavonoids were evaluated for their antioxidant activities using 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH), TBARS (thiobarbituric acid reactive substance) and superoxide anion radical (O2-) in the xanthine/xanthine oxidase assay system. In the DPPH scavenging assay, the IC50 values were 4.5 +/- 0.48 microM for compound 2 and 9.7 +/- 0.29 microM for compound 3, which showed an antioxidant activity approximately 1.5-2 times higher than the antioxidant activity of alpha-tocopherol (9.8 +/- 0.94 microM). Additionally, the antioxidant activities of myricitrin-5-methyl ether (2) (IC50 = 1.7 +/- 0.22 microM) and quercetrin (4) (IC50 = 1.9 +/- 0.63 microM) were higher than that of L-ascorbic acid (IC50 = 7.4 +/- 0.63 microM) when evaluated using a TBARS assay. Compound 2 showed high activity in both the inhibition of xanthine oxidase (1.1 +/- 0.21 mM) and in the activation of superoxide scavenging.

Authors+Show Affiliations

Graduate School of Biotechnology & Plant Metabolism Research Center, Kyung Hee University, Suwon 449-701, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17366733

Citation

Jung, Sung Je, et al. "Flavonoids From the Flower of Rhododendron Yedoense Var. Poukhanense and Their Antioxidant Activities." Archives of Pharmacal Research, vol. 30, no. 2, 2007, pp. 146-50.
Jung SJ, Kim DH, Hong YH, et al. Flavonoids from the flower of Rhododendron yedoense var. poukhanense and their antioxidant activities. Arch Pharm Res. 2007;30(2):146-50.
Jung, S. J., Kim, D. H., Hong, Y. H., Lee, J. H., Song, H. N., Rho, Y. D., & Baek, N. I. (2007). Flavonoids from the flower of Rhododendron yedoense var. poukhanense and their antioxidant activities. Archives of Pharmacal Research, 30(2), 146-50.
Jung SJ, et al. Flavonoids From the Flower of Rhododendron Yedoense Var. Poukhanense and Their Antioxidant Activities. Arch Pharm Res. 2007;30(2):146-50. PubMed PMID: 17366733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonoids from the flower of Rhododendron yedoense var. poukhanense and their antioxidant activities. AU - Jung,Sung Je, AU - Kim,Dong-Hyun, AU - Hong,Yoon-Hee, AU - Lee,Jin-Hee, AU - Song,Hyo-Nam, AU - Rho,Young-Deok, AU - Baek,Nam-In, PY - 2007/3/21/pubmed PY - 2007/3/30/medline PY - 2007/3/21/entrez SP - 146 EP - 50 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 30 IS - 2 N2 - Antioxidant flavonoids have been isolated from the flower of Rhododendron yedoense var. poukhanense. One new flavonoid and three known flavonoids, quercetin-5-O-beta-D-glucopyranoside (1), quercetin (3), and quercitrin (4), were isolated from the butanol and ethyl acetate extracts of the plant. The new flavonoid was identified as myricitrin-5-methyl ether (2). The isolation of these flavonoids from this plant, for the first time, is a valuable finding. The flavonoids were evaluated for their antioxidant activities using 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH), TBARS (thiobarbituric acid reactive substance) and superoxide anion radical (O2-) in the xanthine/xanthine oxidase assay system. In the DPPH scavenging assay, the IC50 values were 4.5 +/- 0.48 microM for compound 2 and 9.7 +/- 0.29 microM for compound 3, which showed an antioxidant activity approximately 1.5-2 times higher than the antioxidant activity of alpha-tocopherol (9.8 +/- 0.94 microM). Additionally, the antioxidant activities of myricitrin-5-methyl ether (2) (IC50 = 1.7 +/- 0.22 microM) and quercetrin (4) (IC50 = 1.9 +/- 0.63 microM) were higher than that of L-ascorbic acid (IC50 = 7.4 +/- 0.63 microM) when evaluated using a TBARS assay. Compound 2 showed high activity in both the inhibition of xanthine oxidase (1.1 +/- 0.21 mM) and in the activation of superoxide scavenging. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/17366733/Flavonoids_from_the_flower_of_Rhododendron_yedoense_var__poukhanense_and_their_antioxidant_activities_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=17366733.ui DB - PRIME DP - Unbound Medicine ER -