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Intake of specific carotenoids and the risk of epithelial ovarian cancer.
Br J Nutr 2007; 98(1):187-93BJ

Abstract

There has been considerable interest in the role of carotenoids in the chemoprevention of cancer. However, few studies have examined the association between intake of specific carotenoids and the risk of epithelial ovarian cancer and the results for carotenoids have been inconclusive. To investigate whether the intake of alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein and zeaxanthin, and lycopene is inversely associated with ovarian cancer risk, a case-control study was conducted in China during 1999-2000. The cases were 254 patients with histologically confirmed epithelial ovarian cancer and 652 age-matched controls were randomly recruited during the same period. Habitual dietary intake and lifestyle were collected by face-to-face interview using a validated and reliable FFQ. The US Department of Agriculture nutrient composition database was used to calculate the intake of specific carotenoids. Unconditional logistic regression analyses were used to estimate OR and 95 % CI, accounting for age, locality, education, BMI, smoking, tea drinking, parity, oral contraceptive use, hormone replacement therapy, menopausal status, family history of ovarian cancer, physical activity and energy intake. Compared with the highest v. the lowest quartile of intake, the adjusted OR were 0.39 (95 % CI 0.23, 0.66) for alpha-carotene, 0.51 (95 % CI 0.31, 0.84) for beta-carotene, 0.51 (95 % CI 0.31, 0.83) for beta-cryptoxanthin, 0.45 (0.27, 0.76) for lutein and zeaxanthin, and 0.33 (95 % CI 0.20, 0.56) for total carotenoids, with statistically significant tests for trend. It is concluded that a higher intake of carotenoids can reduce the risk of epithelial ovarian cancer.

Authors+Show Affiliations

School of Population Health, the University of Western Australia, Crawley, Perth, WA, Australia. min.zhang@uwa.edu.auNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17367574

Citation

Zhang, Min, et al. "Intake of Specific Carotenoids and the Risk of Epithelial Ovarian Cancer." The British Journal of Nutrition, vol. 98, no. 1, 2007, pp. 187-93.
Zhang M, Holman CD, Binns CW. Intake of specific carotenoids and the risk of epithelial ovarian cancer. Br J Nutr. 2007;98(1):187-93.
Zhang, M., Holman, C. D., & Binns, C. W. (2007). Intake of specific carotenoids and the risk of epithelial ovarian cancer. The British Journal of Nutrition, 98(1), pp. 187-93.
Zhang M, Holman CD, Binns CW. Intake of Specific Carotenoids and the Risk of Epithelial Ovarian Cancer. Br J Nutr. 2007;98(1):187-93. PubMed PMID: 17367574.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intake of specific carotenoids and the risk of epithelial ovarian cancer. AU - Zhang,Min, AU - Holman,C D'Arcy J, AU - Binns,Colin W, Y1 - 2007/03/19/ PY - 2007/3/21/pubmed PY - 2007/9/20/medline PY - 2007/3/21/entrez SP - 187 EP - 93 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 98 IS - 1 N2 - There has been considerable interest in the role of carotenoids in the chemoprevention of cancer. However, few studies have examined the association between intake of specific carotenoids and the risk of epithelial ovarian cancer and the results for carotenoids have been inconclusive. To investigate whether the intake of alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein and zeaxanthin, and lycopene is inversely associated with ovarian cancer risk, a case-control study was conducted in China during 1999-2000. The cases were 254 patients with histologically confirmed epithelial ovarian cancer and 652 age-matched controls were randomly recruited during the same period. Habitual dietary intake and lifestyle were collected by face-to-face interview using a validated and reliable FFQ. The US Department of Agriculture nutrient composition database was used to calculate the intake of specific carotenoids. Unconditional logistic regression analyses were used to estimate OR and 95 % CI, accounting for age, locality, education, BMI, smoking, tea drinking, parity, oral contraceptive use, hormone replacement therapy, menopausal status, family history of ovarian cancer, physical activity and energy intake. Compared with the highest v. the lowest quartile of intake, the adjusted OR were 0.39 (95 % CI 0.23, 0.66) for alpha-carotene, 0.51 (95 % CI 0.31, 0.84) for beta-carotene, 0.51 (95 % CI 0.31, 0.83) for beta-cryptoxanthin, 0.45 (0.27, 0.76) for lutein and zeaxanthin, and 0.33 (95 % CI 0.20, 0.56) for total carotenoids, with statistically significant tests for trend. It is concluded that a higher intake of carotenoids can reduce the risk of epithelial ovarian cancer. SN - 0007-1145 UR - https://www.unboundmedicine.com/medline/citation/17367574/Intake_of_specific_carotenoids_and_the_risk_of_epithelial_ovarian_cancer_ L2 - https://www.cambridge.org/core/product/identifier/S0007114507690011/type/journal_article DB - PRIME DP - Unbound Medicine ER -