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Interaction between Apolipoprotein epsilon 4 and traumatic brain injury in patients with Alzheimer's disease and Mild Cognitive Impairment.
Funct Neurol. 2006 Oct-Dec; 21(4):223-8.FN

Abstract

Several pathogenetic factors seem to contribute to the development of Alzheimer's disease (AD). Some data point to a role for traumatic brain injury (TBI), but this suggestion is not universally supported. Mayeux et al. have shown that TBI increases the risk of AD, but only through a synergistic relationship with apolipoprotein epsilon (Apo E) 4. We present the results of a cross-sectional and longitudinal study of the relationship between these factors, conducted in northern and southern Italy. We studied 337 consecutive patients with probable AD and 63 subjects with mild cognitive impairment (MCI). Information concerning head injuries was collected by interview of informants and review of medical records. Twenty-one patients with AD and 9 with MCI were found to have a history of TBI with loss of consciousness. AD and MCI patients with a history of TBI, compared with control groups matched for age, sex, education and degree of mental impairment, showed more marked depressive and behavioural disturbances (Global Deterioration Scale and Neuropsychiatric Inventory, p<0.05). Six- and 12-month follow up of both groups did not show significant differences in the rate of progression of cognitive changes. A high frequency of Apo E 4 was detected in the patients with TBI and cognitive impairment (40.5% in the AD and 11% in the MCI subgroups). The distribution of the epsilon 4 allele in our control group was 4%, comparable to that found in the Italian population. Distribution of the above parameters was similar in patients from northern and southern Italy. The higher frequency of TBI and Apo E 4 genotype among AD and MCI patients confirms the synergistic interaction of environmental and genetic factors in the development of dementia. Our data do not suggest that the presence of these two factors influences the clinical presentation or the course of the disease.

Authors+Show Affiliations

Section of Neurology, Department of Clinical Medicine, Universitá dell'Insubria, Varese, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17367583

Citation

Mauri, Marco, et al. "Interaction Between Apolipoprotein Epsilon 4 and Traumatic Brain Injury in Patients With Alzheimer's Disease and Mild Cognitive Impairment." Functional Neurology, vol. 21, no. 4, 2006, pp. 223-8.
Mauri M, Sinforiani E, Bono G, et al. Interaction between Apolipoprotein epsilon 4 and traumatic brain injury in patients with Alzheimer's disease and Mild Cognitive Impairment. Funct Neurol. 2006;21(4):223-8.
Mauri, M., Sinforiani, E., Bono, G., Cittadella, R., Quattrone, A., Boller, F., & Nappi, G. (2006). Interaction between Apolipoprotein epsilon 4 and traumatic brain injury in patients with Alzheimer's disease and Mild Cognitive Impairment. Functional Neurology, 21(4), 223-8.
Mauri M, et al. Interaction Between Apolipoprotein Epsilon 4 and Traumatic Brain Injury in Patients With Alzheimer's Disease and Mild Cognitive Impairment. Funct Neurol. 2006;21(4):223-8. PubMed PMID: 17367583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between Apolipoprotein epsilon 4 and traumatic brain injury in patients with Alzheimer's disease and Mild Cognitive Impairment. AU - Mauri,Marco, AU - Sinforiani,Elena, AU - Bono,Giorgio, AU - Cittadella,Rita, AU - Quattrone,Aldo, AU - Boller,François, AU - Nappi,Giuseppe, PY - 2007/3/21/pubmed PY - 2007/5/30/medline PY - 2007/3/21/entrez SP - 223 EP - 8 JF - Functional neurology JO - Funct. Neurol. VL - 21 IS - 4 N2 - Several pathogenetic factors seem to contribute to the development of Alzheimer's disease (AD). Some data point to a role for traumatic brain injury (TBI), but this suggestion is not universally supported. Mayeux et al. have shown that TBI increases the risk of AD, but only through a synergistic relationship with apolipoprotein epsilon (Apo E) 4. We present the results of a cross-sectional and longitudinal study of the relationship between these factors, conducted in northern and southern Italy. We studied 337 consecutive patients with probable AD and 63 subjects with mild cognitive impairment (MCI). Information concerning head injuries was collected by interview of informants and review of medical records. Twenty-one patients with AD and 9 with MCI were found to have a history of TBI with loss of consciousness. AD and MCI patients with a history of TBI, compared with control groups matched for age, sex, education and degree of mental impairment, showed more marked depressive and behavioural disturbances (Global Deterioration Scale and Neuropsychiatric Inventory, p<0.05). Six- and 12-month follow up of both groups did not show significant differences in the rate of progression of cognitive changes. A high frequency of Apo E 4 was detected in the patients with TBI and cognitive impairment (40.5% in the AD and 11% in the MCI subgroups). The distribution of the epsilon 4 allele in our control group was 4%, comparable to that found in the Italian population. Distribution of the above parameters was similar in patients from northern and southern Italy. The higher frequency of TBI and Apo E 4 genotype among AD and MCI patients confirms the synergistic interaction of environmental and genetic factors in the development of dementia. Our data do not suggest that the presence of these two factors influences the clinical presentation or the course of the disease. SN - 0393-5264 UR - https://www.unboundmedicine.com/medline/citation/17367583/Interaction_between_Apolipoprotein_epsilon_4_and_traumatic_brain_injury_in_patients_with_Alzheimer's_disease_and_Mild_Cognitive_Impairment_ L2 - http://www.functionalneurology.com/index.php?PAGE=article&amp;ID=1891 DB - PRIME DP - Unbound Medicine ER -